Research Objectives To compare characteristics of caregivers of adults with acute TBI in the U.S. and Latin America (Mexico and Colombia). Design Secondary data analysis of two cohorts. Setting Inpatient Participants Cohort 1: English-speaking caregivers of adults with acute TBI in the U.S. (n=63). Cohort 2: Spanish-speaking caregivers of adults with acute TBI in Mexico or Colombia (n=109). Interventions Not applicable Main Outcome Measures Caregiver age, gender, role-type, marital status, employment status, depressive symptoms (Patient Health Questionnaire); TBI etiology. Results U.S. caregivers were age 51.2 (SD=13.5), predominantly women (84.1%), and mainly spouses/domestic partners (47.6%). Most were employed full-time (63.5%) or retired (20.6%). Latin American caregivers were age 41.5 (SD=13.9; versus U.S.: t89=4.49, p < .001), predominantly women (81.7%), and mainly spouses/partners (31.2%). They were mostly homemakers (31.2%) and employed full-time (25.7%) or part-time (20.2%). In the U.S., the most common cause of TBI was falls (44.4%), followed by motor vehicle accidents (MVA) (38.1%), whereas in Latin America, the most common cause was MVA (48.6%), followed by falls (21.1%) and violence (15.6%; 3.2% in the U.S). Caregivers endorsed mild depressive symptoms in the U.S. (PHQ=8.02, SD=6.11) and in Latin America (PHQ=5.78, SD=5.74; t89=2.37, p=.0358). Conclusions TBI caregivers in the U.S. were older and employed full-time or retired more often than those in Latin America. Their care recipients were more likely to be injured in a fall. Violence-related etiology was nearly 5x more common in Latin America than the U.S, raising concerns for potential implications of post-traumatic stress recovery and family adjustment after injury. Although both groups likely could use mental health support, this was particularly true of the U.S. cohort, and this may be due in part to differential demographics and mechanisms of injury. Author(s) Disclosures This represents a TBI Model Systems Caregiver SIG colloboration, supported by National Institute for Disability, Independent Living, and Rehabilitation Research (NIDILRR) funding. Data collection was supported by NIDILRR (grant numbers: 90DPTB0013; 90DPTB0003; 90DPTB0014) and Grant #R21TW009746 from Fogarty International Center of the National Institutes of Health and in part by the Department of Veterans Affairs. To compare characteristics of caregivers of adults with acute TBI in the U.S. and Latin America (Mexico and Colombia). Secondary data analysis of two cohorts. Inpatient Cohort 1: English-speaking caregivers of adults with acute TBI in the U.S. (n=63). Cohort 2: Spanish-speaking caregivers of adults with acute TBI in Mexico or Colombia (n=109). Not applicable Caregiver age, gender, role-type, marital status, employment status, depressive symptoms (Patient Health Questionnaire); TBI etiology. U.S. caregivers were age 51.2 (SD=13.5), predominantly women (84.1%), and mainly spouses/domestic partners (47.6%). Most were employed full-time (63.5%) or retired (20.6%). Latin American caregivers were age 41.5 (SD=13.9; versus U.S.: t89=4.49, p < .001), predominantly women (81.7%), and mainly spouses/partners (31.2%). They were mostly homemakers (31.2%) and employed full-time (25.7%) or part-time (20.2%). In the U.S., the most common cause of TBI was falls (44.4%), followed by motor vehicle accidents (MVA) (38.1%), whereas in Latin America, the most common cause was MVA (48.6%), followed by falls (21.1%) and violence (15.6%; 3.2% in the U.S). Caregivers endorsed mild depressive symptoms in the U.S. (PHQ=8.02, SD=6.11) and in Latin America (PHQ=5.78, SD=5.74; t89=2.37, p=.0358). TBI caregivers in the U.S. were older and employed full-time or retired more often than those in Latin America. Their care recipients were more likely to be injured in a fall. Violence-related etiology was nearly 5x more common in Latin America than the U.S, raising concerns for potential implications of post-traumatic stress recovery and family adjustment after injury. Although both groups likely could use mental health support, this was particularly true of the U.S. cohort, and this may be due in part to differential demographics and mechanisms of injury.