The use of spent mushroom compost (SMC) as a media amendment for containerized greenhouse and nursery crop production is a promising alternative to disposal of this by-product of mushroom production. Fresh SMC is the compost that is removed from the mushroom house and used without further weathering. The objectives of this study include first, identification of key factors involved its successful use and second demonstration of the effective use of SMC by nurserymen. The plant material used includes both bedding plants and woody perennial species. Results demonstrate that the key factor in the use of SMC for plant production is high soluble salts. Leaching can reduce the high soluble salts. In addition, special consideration should be given to the reduction in potted media volume over time due to composting that continues after the material is removed from mushroom production. SMC as the sole growing media was not as effective as when SMC was amended with a commercial nursery growing mix. Several species were grown in 0%, 25%, 50%, 75%, and 100% mixtures of SMC and a commercial nursery mix. All species grew well in 50% SMC/50% nursery mix.