Sugarcane, a vital commercial crop globally, faces significant challenges due to soil salinity, particularly in India where regions such as Gujarat, Uttar Pradesh, Maharashtra, West Bengal, and Rajasthan are notably affected. Salinity impairs sugarcane growth through reduced water uptake, ion toxicity, nutrient imbalance, stunted growth and soil structure degradation. To combat these issues, various strategies have been proposed, including improving drainage, leaching, selecting salt-tolerant varieties, optimizing irrigation, and using soil amendments. Bio-saline agriculture, incorporating plant growth-promoting rhizobacteria (PGPR) and salt-tolerant plants, offers an innovative approach by enhancing soil fertility and crop resilience under saline conditions. Additionally, research indicates that long-term irrigation practices can exacerbate soil salinity, altering key soil parameters such as pH, electrical conductivity and sodium levels. Studies on spent wash application show variable impacts on sugarcane yield and quality, with optimal results observed at moderate application rates. Effective management of soil salinity through these combined approaches can mitigate adverse effects and improve sugarcane productivity and sustainability.