Objective: To investigate the status of coinfection by respiratory viruses and invasive Aspergillus. It is hoped that the review will help scientists better understand coinfection by respiratory viruses and invasive Aspergillus. The results of this analysis will raise scientist awareness to better facilitate protection and control research pertaining to this disease. Background: According to the latest data from the World Health Organization, coronavirus disease 2019 (COVID-19) has affected more than 200 countries and regions around the world as of February 1, 2021, with a total of 27,864,529 confirmed cases and 2,234,239 deaths, posing a great challenge to human health. A retrospective analysis of 99 cases of COVID-19 was reported in The Lancet on January 29, 2020 and reported COVID-19 patients coinfected with Aspergillus for the first time. Methods: PubMed and Web of Science databases were searched for all papers related to coinfection by emerging respiratory viruses and invasive Aspergillus in the 21st century on February 1, 2021. We sorted and organized these data into the following categories: Patient age and sex, underlying diseases, Aspergillus strains, patient mortality information, and medication. Conclusions: The development of new clinical laboratory diagnostic technology to reduce the cost of diagnosis is necessary for reducing the mortality rate of the patients coinfected with invasive Aspergillus and respiratory virus. © 2021 AME Publishing Company. All rights reserved.