Today, oral and (OMF) surgery encompasses a great range of surgical treatments, from simple tooth extractions to complicated reconstructive craniofacial procedures. This surgical specialty has emerged and evolved from the formal practice of dentistry, dating back to 1844, when two physicians opened the first school of dentistry in Baltimore. Over the next 100 years the specialty continued to take shape. Multiple societies were established, beginning in 1918 as the American Society of Exodontists. In 1921, it became the American Society of Oral Surgeons and Exodontists, in 1946 shortening the name to the American Society of Oral Surgeons. In 1977 the term maxillofacial was formally added, reflecting its current designation and finally describing the tremendous range of skills these specialists master and provide to patients. 1 From an anesthetic standpoint, these procedures may range from the routine application of local anesthetics and titration of intravenous sedation, to the administration of general anesthesia involving skilled airway management techniques, complicated invasive monitoring devices, hemodynamic instability, and significant blood loss. These patients range from ambulatory same-day surgery patients to critically ill inpatients presenting in community hospitals or university medical centers. This is a reflection of the overall growth of this surgical specialty, crossing over to other specialties, including otolarymgology, plastic surgery, and even general surgery. This chapter will present the management of the patient presenting for a variety of major OMF procedures. The relevant anatomic structures of the facial and cranial skeleton involved in these procedures will be reviewed. The preoperative evaluation and preparation, anesthetic concerns and complications, and postoperative management of patients presenting for OMF surgery will follow this. Topics will include exodontia, orthognathic surgery, trauma and infections, tumors, and reconstructive surgery.