PurposeIn 1979, P. Wintgen obtained a basic relationship between the extrinsic normal curvature the intrinsic Gauss curvature, and squared mean curvature of any surface in a Euclidean 4-space with the equality holding if and only if the curvature ellipse is a circle. In 1999, P. J. De Smet, F. Dillen, L. Verstraelen and L. Vrancken gave a conjecture of Wintgen inequality, named as the DDVV-conjecture, for general Riemannian submanifolds in real space forms. Later on, this conjecture was proven to be true by Z. Lu and by Ge and Z. Tang independently. Since then, the study of Wintgen’s inequalities and Wintgen ideal submanifolds has attracted many researchers, and a lot of interesting results have been found during the last 15 years. The main purpose of this paper is to extend this conjecture of Wintgen inequality for bi-slant submanifold in conformal Sasakian space form endowed with a quarter symmetric metric connection.Design/methodology/approachThe authors used standard technique for obtaining generalized Wintgen inequality for bi-slant submanifold in conformal Sasakian space form endowed with a quarter symmetric metric connection.FindingsThe authors establish the generalized Wintgen inequality for bi-slant submanifold in conformal Sasakian space form endowed with a quarter symmetric metric connection, and also find conditions under which the equality holds. Some particular cases are also stated.Originality/valueThe research may be a challenge for new developments focused on new relationships in terms of various invariants, for different types of submanifolds in that ambient space with several connections.