Oxygenic therapy mean the medical efforts to improve the partial pressure of oxygen (PaO2) and arterial oxygen saturation (SaO2) in the alveoli of patients by inhaling oxygen concentration higher than that in the air, so as to increase arterial oxygen content (CaO2) and correct the hypoxia caused by various reasons, and thus promoting the metabolism of tissues. Besides, it is a therapeutic method to maintain the body's vital activity, which is widely used in clinical work. This paper mainly aims at the application of oxygen inhalation therapy in clinical work, and finds out the cause analysis and countermeasures of the problems of oxygen therapy in nursing clinic.