Papillon-Lefevre syndrome (PLS) is an autosomal recessive disorder that affects the primary and permanent dentitions. It is characterized by severe periodontitis. Titanium implants have emerged as a significant therapeutic option in recent years for both tooth replacement and oral rehabilitation in individuals with PLS. Due to the severe bone loss, these patients may require bone grafting procedures, sinus lifts, and the alveolar ridge splitting technique (ARST) in order to properly position the implants. This report aims to demonstrate how a patient with PLS can be successfully managed for full-mouth rehabilitation with dental implants and hybrid prosthesis. Periodontists and prosthodontists should combine their efforts for an optimal customized treatment plan. Dental implants have been successfully used to restore functionally and esthetically the patient’s mouth.
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