Aluminum Phosphide Poisoning Research Articles

Dietary Intake and Plasma Levels of Antioxidant Vitamins in Health and Disease: A Hospital-based Case-control Study

Of 1667 subjects that attended the hospital, 1335 were patients with diagnosed medical conditions, together with 202 randomly selected, apparently healthy controls from the same population, were studied in detail for demographic variables, dietary and biochemical data. Dietary consumption of antioxidant vitamins A, E, and C and β-carotene and soluble fibre was lower in the majority of conditions compared to controls. Plasma concentrations of vitamin C and β-carotene were significantly lower in all patient groups. Reduced vitamin E levels were noted in patients with cardiovascular diseases, stroke, Parkinson's disease, chronic renal failure, nephrotic syndrome, type A behaviour, post-partum psychosis, burns, liver diseases, cancer, rheumatoid arthritis and aluminium phosphide poisoning. Lipid peroxides (thiobarbituric acid reactive substances), which are an indicator of oxygen-derived free radical damage, were significantly higher than controls in most conditions and marginally higher in respiratory and ps...

Aluminum phosphide poisoning--a review.

Aluminum phosphide poisoning is common in the rural belt of Northern India. The release of cytotoxic phosphine gas primarily affects the heart, lungs, gastrointestinal tract and kidneys, although all organs can be involved. The cellular site of action of phosphine requires further definition. Diagnosis is made by clinical suspicion, silver nitrate test and biochemical examination of the gastric aspirate and viscera. Treatment consists of early gastric lavage, vasopressors and supportive care. Specific therapy with intravenous magnesium sulphate is recommended.

Acute phosphine poisoning following ingestion of aluminium phosphide.

1. Eight cases of phosphine poisoning following ingestion of aluminium phosphide tablets for suicidal attempt are described. The mean age of the patients was 23 years (range 14-25). 2. The clinical picture consisted of gastritis, altered sensorium and peripheral vascular failure in all cases, cardiac arrhythmia (3), jaundice and renal failure (1 each). Six patients died, the mean hospital stay was 19 h (range 4-72). 3. Post-mortem examination was performed in two patients, revealing pulmonary oedema, gastrointestinal mucosal congestion, petechial haemorrhages on the surface of liver and brain. Histopathological changes included pulmonary oedema, desquamation of the lining epithelium of the bronchioles; vacuolar degeneration of hepatocytes, dilatation and engorgement of hepatic central veins, sinusoids and areas showing nuclear fragmentation. 4. The clinical picture of aluminum phosphide poisoning is described and precaution in the distribution and use of this pesticide recommended.

Aluminium phosphide poisoning: a prospective study of 16 cases in one year.

Sixteen patients suffering from aluminium phosphide poisoning were treated during the year from January 1985 to December 1985. These accounted for approximately half the total number of cases of acute poisoning. Profuse vomiting, pain in the upper abdomen and shock were the most common presenting features. Six patients succumbed to their illness. Analysis of various prognostic factors revealed that ingestion of 'unexposed' tablets of aluminium phosphide taken from a freshly opened bottle was associated with a greater risk of fatal outcome. Aluminium phosphide poisoning has become an important matter of public health in parts of India.

Pilot Survey on Cases of Poisoning and its Outcome in Different Category of Hospitals in Bangladesh

Poisoning and snakebite are commonly encountered emergency situation in Bangladesh. Morbidity per annum reported from static primary health care set up and district hospitals following poisoning are ~ 0.56% of total morbidity. Reports published from the DGHS in 2001 recorded poisoning as fifteenth cause of morbidity & second commonest cause of death second to acute respiratory tract infection (1956). Common poisoning encountered in the community include pesticide poisoning, kerosene poisoning, poisoning by unknown sedative substances for stupefying purpose and with occasional reports of methanol poisoning, aluminium phosphide poisoning, copper sulphate poisoning and puffer fish poisoning. A change in the trends of poisoning particularly ‘travel related' poisoning by sedatives instead of previously used ‘Dhatura' have been found in the country.  doi:10.3329/jom.v10i3.2010 J Medicine 2009; 10 (Supplement 1): 15-17