This paper investigates the efficacy of solar energy-driven water desalination with nanoparticle integration for enhancing efficiency, sustainability, and potable water production in arid regions. The study employs a multidisciplinary approach combining theoretical analysis, computational simulations, and experimental validation to assess the performance of the proposed distillation system. Theoretical analysis involves a comprehensive literature review to identify relevant parameters and frameworks, while computational simulations model the system’s dynamic behavior under different conditions. Laboratory-scale experiments validate the findings of the simulations and assess practical feasibility. Results reveal the composition of nanoparticles, demonstrating significant proportions of Copper Oxide, Aluminium Oxide, and Titanium Oxide, among others. Efficiency comparison shows a substantial increase in distillation efficiency with nanoparticle integration compared to traditional methods. Sustainability factors analysis highlights the importance of renewable energy, sustainable materials, nanoparticle integration, and waste reduction strategies. Furthermore, potable water production analysis reveals varying proportions across different regions, emphasizing the need for region-specific considerations. Overall, the study underscores the potential of solar energy-driven water desalination with nanoparticle integration as a sustainable solution for addressing water scarcity in arid regions.