Building a superior balance of strength and plasticity inversion is a challenge in the development of aluminum matrix composites reinforced with medium volume fraction SiC particles. In this study, we reported an interface design strategy to simultaneously enhance the strength and plasticity of 30 vol% SiCp/Al composite by in-situ generating SiC@MgAl2O4 core-shell micro-nanostructures. The results showed that a uniform MgAl2O4 shell layer with a thickness of ∼300 nm was formed when the Mg content was 4.0 wt%. The MgAl2O4 shell layer formed abundant coherent interfaces with both SiC particles and aluminum alloy matrix, exhibiting powerful interfacial bonding strength. During the deformation process, the effective transmission of load and the delay of fracture achieved a synergistic improvement in both strength and plasticity.