Aluminum Phosphide Research Articles

Study of pattern and outcome of acute poisoning cases at tertiary care hospital in North India.

The WHO 2021 data estimate that 2 million lives and 53 million disability-adjusted life-years were lost in 2019 due to exposures to selected chemicals. It is important to know the pattern and outcome of acute poisoning cases for proper planning, prevention and management. Knowing the pattern will also help in designing training modules for primary care physicians to make them aware about newer poisons and their management. Awareness regarding newer poisons consumed is necessary for early identification, initial management and timely referral to higher centres by primary care physicians. This study was performed to see the pattern and outcome of acute poisoning cases in North Indian population and various factors related to outcome. This study was conducted in department of medicine of a teaching institute in North India after approval by the Institutional Review Board. Patients admitted in the department during the study and fulfilling the inclusion criteria were enrolled in the study after obtaining consent. A total of 417 patients with poisoning were recruited in the study. Out of 417 patients, majority were males (59.5%). Maximum number of patients were in the age group of 21-30 years (33.8%), and rural population (79.9%) was found to be more affected. Most of the patients were students and private employees. Most common types of poisoning were snakebite (n = 109, 26.1%), organophosphate (n = 49, 11.8%) and aluminium phosphide (n = 39, 9.3%). Out of 417 patients, 349 (83.69%) improved, while 68 (16.3%) expired. Requirement of ventilatory support was most commonly associated with aluminium phosphide poisoning (30.12%) followed by organophosphate poisoning (24.1%). Poisoning was more common in young males and more prevalent in rural population. Pesticides and snakebite were major causes of poisoning. Among suicidal cases, family conflict (problem/altercation with family members/marital discord) was main reason for the consumption of poison. There is need for creation of poison information centre along with separate toxicological units in tertiary care hospitals.

Phosphine estimation in fumigated food grains using gas chromatography equipped with FPD detector.

Phosphine, as per several reports, is considered to be an ideal and effective alternative to methyl bromide (MB) fumigant, phased out globally honouring 'Montreal Protocol'. The food grains fumigated with phosphine are perceived to be residue-free; however, estimation of its residues is imperative. In the present study, the phosphine residues were estimated in grains of wheat, rice, green gram, chickpea and yellow pea fumigated with different formulations of phosphine under 7 and 10days exposure periods at various locations in India. For efficacy studies, the conventional aluminium phosphide (AlP) tablet (56% @2 and 3 tablet/MT) and granular AlP (77.5% @1.0 and 1.5g phosphine/m3) formulations were applied. Each treatment including untreated control was replicated thrice. The concentration was monitored every 24h until the end of exposure periods. Food grain samples were drawn before and post fumigation following a certain waiting period for estimation of phosphine residues using gas chromatography equipped with FPD detector. Residues in fumigated food grains were observed in traces in all the experimental stacks, but below the MRL (0.1ppm), fixed by Codex Alimentarius Commission (CAC). Phosphine can be considered safe for use as an alternate fumigant in quarantine and long-term storage of food grains leaving residues below MRL.

Fatal aluminium phosphide poisoning associated with Brugada electrocardiographic pattern: An exceptional case report

Fatal aluminium phosphide poisoning associated with Brugada electrocardiographic pattern: An exceptional case report

The Effects Of Wheat Pill Poisoning (Aluminum Phosphide) Dosage On Arterial Blood Gases And Their Clinical Outcome.

To analyse the effects of aluminum phosphide poisoning dosage on arterial blood gases and the clinical outcome. The cross-sectional study was conducted at the intensive care unit of Mardan Medical Complex, Mardan, Pakistan, from January 2021 to May 2022, and comprised patients of either gender who had attempted suicide using aluminum phosphide. Data was collected using a predesigned questionnaire. Data was analysed using SPSS 26. Of the 116 patients, 42(36.2%) were males and 74(63.8%) were females. There were 75(64.65) survivors; 31(41.33) males and 44(58.66) females with overall mean age 26.30±9.45 years. There were 41(35.35%) non-survivors; 11(26.82%) males and 30(73.18) females with overall mean age 28.21±11.16 years.During hospitalisation, the non- survivors showed drastically decreased levels of all arterial blood gas paramters with severe clinical outcomes (p<0.05). As the number of aluminum phosphide pills increased, the chance of survival decreased (p<0.05). The non-survivors spent an average of 32.51±16.02 hours in hospital (range: 6-59 hours). Patients who ingested more aluminum phosphide pills had more abnormal arterial blood gas parameter with severe clinical outcomes. Also, they had lower chance of survival and unfavourable response to treatment.

Aluminum Phosphide Poisoning in the North of Iran: A Register-based Research.

Aluminum phosphide (ALP) poisoning is considered one of the health care issues in Iran, which is associated with the mortality outcome of patients. According to the ALP poisoning that commonly results in death, we aimed to evaluate the prevalence of ALP pill poisoning by employing register-based research. In this descriptive cross-sectional study, all selected patients diagnosed and confirmed with ALP poisoning by a specialist and referred to the poisoning ward from the beginning of April 2016 to the end of October 2017 were enrolled, and data were registered in the Disease Registration System by a technical expert for daily follow-up during hospitalization. Approximately 12.4% of patients had neurological problems, with the majority having paresis (68.3%). Self-poisoning with the purpose of suicide was documented for 96.2% of cases, with the most common cause being family problems (54.1%). In 97.3% of cases, the method of contact with the toxic substance was oral. Hypotension, cardiac, and respiratory complications were observed in 25.2%, 30.8%, and 25% of the patients, respectively. The most gastrointestinal symptoms were nausea and vomiting (86.7%). The results indicate that the rate of ALP pill poisoning is relatively high. Suicide is the most important cause of ALP poisoning, which is more common in men under 40 years of age.

Lattice vibration, optical, and mechanical properties of aluminum phosphide (AlP) compound under the influence of temperature

Lattice vibration, optical, and mechanical properties of aluminum phosphide (AlP) compound under the influence of temperature

Evaluation of photobiomodulation effect on cesarean-sectioned wound healing: a clinical study.

The effects of low-level laser on the wound healing and burn injuries have been previously examined to demonstrate some satisfactory results. Despite there are a few articles available to study photobiomodulation (PBM) effects on the pain relief of cesarean sectioned wound, however no systematic examination has been carried out so far regarding its healing. Here, the aim of this clinical study was to evaluate PBM effect on the cesarean-sectioned wound healing. PBM effects of semiconductor lasers are investigated at 658 and 660 nm with 100, 150 and 350 mW output powers on 40 patients. Due to the global increasing number of cesarean sections, we have decided to investigate the effect of laser as a reliable technique to recover the wounds fast. We considered women as the target group who had their first delivery giving the birth of their children by cesarean section. We selected patients are who treated by laser therapy using indium gallium aluminum phosphide (InGaAlP) semiconductor linear scanning type with beam cross section of 12 cm2 and the output power of 100 mW at 658nm exposing a therapeutic dose of 2J/cm2. The purpose is to accelerate the healing process of the wounds after delivery as an intervention group against the people who chose the conventional methods (using ointments, pills, etc.) to heal their cesarean sectioned wounds as the control group. Regarding the wounds of these two groups, the questionnaires were filled by patients to assess the severity of pain from visual analogue scale (VAS) based on the healing of wounds from redness, edema, ecchymosis, discharge, and distance between the two edges of the wound (REEDA) scale in the early hours after surgery and the post-treatment follow-up on the third, seventh, and the tenth days. The data collected by these questionnaires were analyzed using statistical package for social science)SPSS( as a statistical software to give out the comparative histograms. This study reports a clinical examination of PBM under intervention group of 40 patients ranging 18-40years old with body mass index (BMI) of 29-36, during post-cesarean surgery to elucidate successful healing of the wounds and scars against conventional methods which considered as control group. Comparison of mean REEDA scores on the third day (p = 0.035), seventh day (p = 0.03), and tenth day (p = 0.02) after delivery exhibits that the two groups benefit a statistically significant difference with each other. For instance, the mean wound healing score in the intervention group was almost half of the mean wound healing score on the tenth day in the control group (1.09 ± 0.586 vs. 2.25 ± 0.422). The post-cesarean follow-up indicates that the patients treated by the laser therapy (intervention group) encounter better recovery than the control group.

Extracorporeal Membrane Oxygenation in Acute Aluminum Phosphide (AlP) Poisoning

Introduction: Aluminum Phosphide (AlP) poisoning is a life-threatening condition that commonly occurs in developing countries, often resulting in cardiac, respiratory, and metabolic complications, leading to multi-organ failure and mortality. Extracorporeal Membrane Oxygenation (ECMO) has been proposed as a potential therapy for severe AlP poisoning cases refractory to conventional management, though its use remains controversial. Methodology: for this literature review, we conducted a comprehensive analysis of existing literature concerning the utilization of ECMO in patients with severe AlP poisoning. We meticulously examined available publications to explore the relationship between ECMO initiation and patient outcomes. Discussion: The review reveals that early ECMO initiation within 6 hours of presentation is associated with better outcomes and higher survival rates in severe AlP poisoning cases. However, uncertainties persist regarding the optimal timing and duration of ECMO support, and potential complications, including bleeding, acute renal injury, and ventilator-associated pneumonia, need careful consideration. Conclusion: Despite promising results in certain cases, the risks and benefits of ECMO in AlP poisoning require meticulous evaluation. Ethical considerations, encompassing resource allocation and implications for other patients, necessitate appropriate patient selection criteria.

Effect of selected preservatives on nutritional indices of kidney beans (Phaseolus vulgaris)

Preservatives are most often used to maintain the quality of foods for longer time periods. It has been reported that chemicals, which are used as preservatives have some effects (positive or negative) on the nutritive indices of foods. This research was carried out to investigate the effect of some selected preservatives on the nutritive indices of kidney beans (Phaseolus vulgaris). The matured P. vulgaris used for this research were collected in bags from the area of cultivation. Following the established research guidelines, the seeds were prepared and sent to laboratory for analysis prior to storage with selected preservatives. The selected preservatives were procured and prepared for the experimental purpose under standard protocols. The kidney beans were divided into airtight containers and labeled in group 1 to 5, which were preserved with selected preservatives; (DDVP) (sniper), birds eye pepper and Aluminium phosphide, while the fourth group was mixed with ash and the fifth group was left without mixing with any preservative to serve as control. The beans mixed with preservative were left to stay on standard research procedure for 6 months. Standard procedures were used to assess the effect of the preservatives on the proximate compositions, mineral contents, and amino acid concentrations, respectively compared with the control group, which was not mixed with the preservatives. Results of the research showed varying effects of the different preservatives on the beans mixed with preservatives when compared with the control group. There was an observed improvement on the proximate composition of the beans preserved with some of the selected preservatives while some beans were negatively affected as the preservative affected the nutritive quality as compared to control groups; same results were observed for the mineral nutrient constituents and amino acid concentrations. The observed improvements in the experimental parameters showed that the chemicals in some groups were more effective for some aspects while natural preservatives were better for other measured criteria. The effectiveness of the preservatives for a longer shelf life and stop or delay the growth of bacteria, suppress the reaction when food comes in contact with oxygen or heat, they also prevent the loss of some essential amino-acids and some vitamins enhance the food flavors and colors. The results of this study showed that some of the selected preservatives used on the kidney beans suggested that kidney beans could improve the shelf life and improve nutritive value. Key words: Preservatives, Nutrition, Nutritive index, Shelf-life, Storage, proximate analysis, amino acid, minerals

Elucidating the adsorption of 2-Mercaptopyridine drug on the aluminum phosphide (Al12P12) nanocage: A DFT study

Adsorption amplitude of the aluminum phosphide (Al12P12) nanocage toward the 2-Mercaptopyridine (MCP) drug was herein monitored based on density functional theory (DFT) calculations. The adsorption process through MCP⋅⋅⋅Al12P12 complex in various configurations was elucidated by means of adsorption (Eads) energies. According to the energetic affirmations, the Al12P12 nanocage demonstrated potential versatility toward adsorbing the MCP drug within the investigated configurations and exhibited significant negative adsorption energies up to −27.71 kcal/mol. Upon the results of SAPT analysis, the electrostatic forces showed the highest contributions to the overall adsorption process with energetic values up to −74.36 kcal/mol. Concurrently, variations of molecular orbitals distribution along with alterations in the energy gap (Egap) and Fermi level (EFL) of the studied nanocage were denoted after adsorbing the MCP drug. The favorable impact of water solvent within the MCP⋅⋅⋅Al12P12 complexes was unveiled and confirmed by negative solvation energy (ΔEsolv) values up to −17.75 kcal/mol. According to thermodynamic parameters, the spontaneous and exothermic natures of the considered adsorption process were proclaimed by negative values of ΔG and ΔH parameters. Significant changes in the IR and Raman peaks, along with the appearance of new peaks, were noticed, confirming the occurrence of the targeted adsorption process. Furthermore, the adsorption features of the MCP drug on the Al12N12 nanocage were elucidated and compared to the Al12P12 analog. The obtained results demonstrated the higher preferability of Al12P12 nanocage than the Al12N12 candidate towards adsorbing the MCP drug without structural distortion.

Physicians' perspectives on different therapeutic approaches for aluminum phosphide poisoning and their relevant outcomes.

Aluminum phosphide is a highly toxic pesticide that results in high mortality. To date, there is neither a definitive antidote nor a unified protocol for managing acute aluminum phosphide poisoning. This cross-sectional questionnaire-based study aims to explore different management approaches and rely on the expertise of Egyptian medical professionals to enhance the prognosis for acute aluminum phosphide poisoning. A self-administered questionnaire was formulated and electronically distributed according to published literature and experience of senior physicians. Responses were received from 151 physicians from 10 governorates. Management modalities were variable among respondents. Noradrenaline was used by 90.7% of respondents with no fixed-dose regimen. In all, 84.1% of participants utilized oil in gastrointestinal decontamination; paraffin oil was the most used solution. Overall, 92.1, 61.6, 46.4, and 34.4% of participants used sodium bicarbonate, proton pump inhibitors, IV magnesium sulfate, and antioxidants, respectively. Regarding the frequency of acute aluminum phosphide poisoning, 47% of participants managed these cases daily or a few times a week. Participants' responses denoted a poor prognosis of acute aluminum phosphide poisoning, and high percentages attributed the prognosis to exposure factors rather than treatment modalities. Statistical analysis revealed that using oil in gastrointestinal decontamination improved the outcome by 4.62-fold. Clinical toxicologists were more likely to rescue≥30% of the cases about 3-fold (2.97) than other specialties. Clinical toxicologists used oil in gastrointestinal decontamination, magnesium sulfate, and antioxidant therapy and calculated base deficit before administration of sodium bicarbonate by 7.70-, 5.30-, 3.26-, and 2.08-fold than other specialties.

Pattern of acute poisoning that required intensive care unit admission in Tanta University poison control center

Abstract Background Poisoning is an important health care problem resulting in high morbidity and mortality rates especially in developing countries. About 4–40% of acute poisoned patients need intensive care units (ICU). Aim The aim of this study was to evaluate pattern of acute poisoning that required ICU admission, clinical characteristics and outcome of these patients in Tanta University Poison Control Center. Patients and methods All acute poisoned cases who admitted to ICU from the start of February 2017 to the end of July 2018 were included. Sociodemographic, characteristic clinical manifestations, laboratory investigations and outcomes were recorded. Results ICU admitted poisoned patients represented 6% of total poisoned patients. More than half of patients (54.4%) were in the age group between 18 and 40 years and 50.7% of patients were females. The highest percentage were from rural areas (87%) with suicidal intentions (76.8%). The main route of exposure was oral route (95%). Median delay time and hospitalization period were 3 h and 43 h, respectively. The most frequent poisons were aluminum phosphide (61.5%), organophosphates (11.5%) and digitalis (4.8%(. 32.7% of patients were hypotensive and 20.3% presented with undetected blood pressure. Mixed metabolic acidosis with respiratory alkalosis was the most frequent arterial blood gases abnormality (40%) and 51.4% of the studied patients died. Conclusion The most frequent three poisons that required ICU admission were aluminum phosphide, organophosphates and digitalis respectively. The alarming clinical presentations were hypotension, tachycardia, tachypnea and mixed arterial blood gas abnormality.

N-acetylcysteine Use in Treatment of Acute Aluminium Phosphide Poisoning: Systematic Review and Meta-Analysis

N-acetylcysteine Use in Treatment of Acute Aluminium Phosphide Poisoning: Systematic Review and Meta-Analysis

Biochemical and histopathological changes in livers of rats poisoned with aluminum phosphide and treated with carrot extract.

The experimental studies of Aluminum Phosphide (AP) poisoning in rats revealed several clinical and pathological signs such as hemorrhage, sinusoidal dilatation, bile stasis, centrilobular necrosis, Kupffer cell hyperplasia, infiltration by mononuclear cells, and fatty infiltration in the liver tissues. This paper aimed to show the impact of carrots on the toxic effect of AP on the livers of adult rats (female). To investigate some biochemical and histopathological changes effects of AP in rats, sixty white female rats were equally divided into four groups, the first group (G1) was administered orally with 3mg/kg/ body weight of AP, the second group (G2) was orally treated with AP and 10% carrot extract at the same time. The third group (G3) administrated 10% carrot extract only. The fourth (G4) group was the negative control and was treated with distilled water only. The experiments continued for a month at the animal house of the Veterinary Medicine College of Baghdad University. The results revealed that high levels of liver enzymes and bilirubin were induced in G1 with decreasing total protein levels. The pathological examination revealed the presence of marked proliferation of Kupffer cells in G1 livers. However, the G2 group showed slight infiltration of lymphocytes in sinusoids. The pathological changes in the livers of G3 group showed slight cloudy swelling in hepatocytes compared with the normal texture of hepatocytes in G4. The data of this experiment showed that treatment with carrot extract significantly decreases the elevation in the level of liver function enzymes in animal poisoned with AP. In addition, treatment with carrot extract reduces the severe damage in the hepatic tissue that occurred in rats treated with AP only. In general, it could be concluded that treatment with carrot extract provides a remedial effect against the hepatotoxicity that is resulted from exposure to AP.

Identification and sensing of hydrogen fluoride (HF) on aluminum phosphide (Al24P24) nanocage in both gas and water phases: electronic study via density-functional theory computations.

Hydrogen fluoride (HF) is extensively present in environmental and industrial pollutants. It may harm the health of humans and animals. This work evaluated the adsorption of an (HF)n linear chain (n = 1, 2, 3, and 4) onto an AlP nanocage through ab initio calculations for the evaluation of its performance in sensing and monitoring (HF)n within aqueous and gaseous media. The present work adopted density functional theory (DFT) at the 6-311 G (d, p) basis set to analyze (HF)n linear chain adsorption onto AlP nanocages with the B3LYP functional. This paper examined the adsorption energy, configuration optimization, work function, and charge transfer. In addition, the contributions of the HF linear chain size to electronic properties and adsorption energy were measured. The dimer form of HF on the surface of AlP nanocages was found to have the highest stability based on the adsorption energy values. Once (HF)n was adsorbed onto the nanocage, the HOMO-LUMO energy gap experienced a large reduction from 3.87 to 3.03 eV, enhancing electrical conductivity. In addition, AlP nanocages may serve in the sensing of (HF)n under multiple environmental pollutants.

Histopathological and Biochemical Effect of Vitamin C and D on Phosphine-Induced Hepatotoxicity in Wistar Rats

Background: Aluminum phosphide is becoming a very common agent for self-poisoning. The lack of specific antidote for phosphide poisoning has aroused the current interest of research. Objectives: This study aimed to investigate the possible protective effect of Vitamin C and D in phosphine-induced hepatotoxicity in Wistar rats. Methods: In this experimental study, 20 Wistar rats were randomly divided into five groups ( n = 12). Group I was apparently normal Control Group. Groups II-V were induced with 2.5 mg/kg ALP. Groups II was without further treatment while Groups III-IV received vitamin C at 100mg/kg/bw and vitamin D at 10mg/kg/bw. Group V was co-administered with vitamin C at 100mg/kg/bw and vitamin at 10mg/kg/bw. The treatments lasted for 28 days. Results: The results showed that Vitamin C and D (P&lt;0.05) increased antioxidant capacity. Combined active constituents of the Vitamin C and Vitamin D raised the GPX antioxidant activities when compared to the phosphine poisoned group treated individually with Vitamin C and D. The combined activities of Vitamin C and Vitamin D showed the highest antioxidant effect as compared with the control Conclusion: The combined activities of Vitamin C and D supplementation improved the antioxidant defense system and histology of the liver in phosphine poisoning. Keywords: Metal phosphide, Carotene, Liver cell damage, Poison

Prevalence and Life-Threatening Electrocardiographic Changes in Aluminum Phosphide Poisoned Patients

Background: According to World Health Organization report, poisoning with phosphides is the most common fatal poisoning in most of the world, especially developing countries. One of the leading causes of morbidity and mortality in these patients is cardiovascular complications; therefore, the researchers aimed to study the prevalence and type of electrocardiographic changes, especially life-threatening electrocardiographic changes observed in poisoned patients with aluminum Phosphide.&#x0D; Methods: This retrospective cohort study was carried out on all the individuals poisoned with aluminum phosphide tablet and were admitted to the toxicology center in northwest Iran and met the inclusion criteria and no exclusion criteria. After categorization, the data were entered into SPSS (SPSS Inc, Chicago, USA) software, and appropriate statistical analyses were done. In all the tests, p&lt;0.05 was considered statistically significant.&#x0D; Results: Our findings pointed out that the majority of the patients were in the 20-40 age group and male-to-female ratio was 2.00. Electrocardiographic changes were prevalent in 86.1 percent of the patients who consumed aluminum phosphide. The most common change was sinus bradycardia. The mean consumed aluminum phosphide was 1.93±1.88 tablets, and the mean interval from consumption to medical care was 3.67±2.05 hr which did not have significant correlations with electrocardiographic changes.&#x0D; Conclusion: The most common electrocardiographic change is bradycardia, but the most lethal is ventricular tachycardia; therefore, taking repeated electrocardiograms and echocardiography could help the decision making in the process of patient management. Definitive conclusions need further studies.

TO STUDY IN-HOSPITAL MORTALITY OF ALUMINIUM PHOSPHIDE POISONING IN RELATION TO TOTAL LEUCOCYTE COUNT

Background: Pesticide poisoning is a major problem worldwide. The incidence of aluminium phosphide poisoning has increased over decades. Phosphine, active form, binds cytochrome oxidase, induces oxidative stress with release of free oxygen radicals, lipid peroxidation, resulting acute inflammation leads to alteration of various haematological/biochemical parameters, including total leucocyte count (TLC). Objectives: 1.To study TLC in aluminium phosphide poisoning 2.To study severity of toxicity in relation to TLC 3.To study in-hospital mortality in relation to TLC Methods: A hospital based cross sectional study with sample size of 65. In-patients with aluminium phosphide poisoning attending Medicine Department in KR Hospital, Mysuru were studied. The parameters like complete hemogram including TLC, liver/renal function tests, electrolytes, electrocardiogram were assessed and correlated. With a confidence interval of 95%, level of significance was kept at 5% Results: Of the 65 subjects, mean age was 34.11 ±11.55 years and mean TLC was 10467.5 ±2991.2 . Subjects were categorised into non-severe(29%), severe(26%) and death(45%) groups. Mean TLC in non severe(8140.7±2445.9), severe(10980.3± 2471.1) and death(11691.4 ±2780.4). A high TLC was found in 15.8% non-severe, 41.2% severe and 69% death cases. A significant positive correlation of TLC with severity of toxicity and mortality of aluminium phosphide poisoning was obtained (p&lt;0.005). Conclusion: Total leucocyte count can be used as one of the easily available cost effective predictive variable to assess the outcome of aluminium phosphide poisoning.

Cardioprotective role of the coenzyme Q10 and coconut oil in acute aluminum phosphide poisoning: a randomized controlled clinical trial.

Aluminum phosphide (ALP)-induced cardiotoxicity is a major cause of high mortality rates. As there is no specific antidote, restoring cardiac hemodynamics is the cornerstone for saving patients. Based on oxidative stress theory in acute ALP poisoning, we examined the cardioprotective role of coconut oil and Coenzyme Q10 (COQ10) in ALP poisoning, focusing on their antioxidant capacity. This study was a randomized, controlled, single-blind, phase II clinical trial conducted at Tanta Poison Control Center over 1 year. Eighty-four ALP poisoned patients received supportive treatment and were randomly allocated to three equal groups. Gastric lavage was performed using sodium bicarbonate 8.4% with saline in group I. Alternatively, group II received 50ml coconut oil, and group III initially received 600mg CoQ10 dissolved in 50ml coconut oil; and repeated 12hours later. In addition to patient characteristics, clinical, laboratory, electrocardiography (ECG), and total antioxidant capacity (TAC) data were recorded and repeated 12hours later. Patient outcomes were evaluated. There was no significant difference among groups considering patient characteristics, initial cardiotoxicity severity, vital, laboratory data, ECG changes, and TAC. However, 12hours post-admissions, group III was significantly improved in all clinical, laboratory, and ECG parameters than comparable groups. Significant correlations were observed between elevated TAC in groups II and III with hemodynamic, serum troponin, and ECG variables. Accordingly, the need for intubation, mechanical ventilation, and the total vasopressor dose was significantly decreased in group III compared with other groups. Therefore, coconut oil and COQ10 are promising cardioprotective adjuvant therapy ameliorating the ALP-induced cardiotoxicity.

Pattern and predictors of death from aluminum and zinc phosphide poisoning using multi-kernel optimized relevance vector machine

The use of metal phosphides, particularly aluminum phosphide, poses a significant threat to human safety and results in high mortality rates. This study aimed to determine mortality patterns and predictive factors for acute zinc and aluminum phosphide poisoning cases that were admitted to Menoufia University Poison and Dependence Control Center from 2017 to 2021. Statistical analysis revealed that poisoning was more common among females (59.7%), aged between 10 and 20 years, and from rural regions. Most cases were students, and most poisonings were the result of suicidal intentions (78.6%). A new hybrid model named Bayesian Optimization-Relevance Vector Machine (BO-RVM) was proposed to forecast fatal poisoning. The model achieved an overall accuracy of 97%, with high positive predictive value (PPV) and negative predictive value (NPV) values of 100% and 96%, respectively. The sensitivity was 89.3%, while the specificity was 100%. The F1 score was 94.3%, indicating a good balance between precision and recall. These results suggest that the model performs well in identifying both positive and negative cases. Additionally, the BO-RVM model has a fast and accurate processing time of 379.9595 s, making it a promising tool for various applications. The study underscores the need for public health policies to restrict the availability and use of phosphides in Egypt and adopt effective treatment methods for phosphide-poisoned patients. Clinical suspicion, positive silver nitrate test for phosphine, and analysis of cholinesterase levels are useful in diagnosing metal phosphide poisoning, which can cause various symptoms.