Nanotubular titania (NT) to be used as support for CoMo-based hydrodesulfurization (HDS) catalyst was synthesized and characterized by various techniques. NT annealed at 400 °C (under nitrogen) was constituted by nanotubes of ∼5.5 nm (internal diameter) and retained 236 m 2/g of surface area. Mo at 3 atoms/nm 2 (nominal loading) and cobalt at Co/(Co + Mo) = 0.3 were impregnated under nearly neutral, acidic or basic media. By XPS analyses of NT-supported sulfided catalysts, highly dispersed MoS 2 particles of low stacking degree (1–2 slabs) aligned along the nanotubes were observed by HR-TEM in all sulfided materials. The CoMo catalysts supported on nanostructured titania had dibenzothiophene (DBT) HDS activity (in pseudo first order kinetic constant basis) values ∼1.35 and ∼1.7 times (Mo impregnated under near neutral and basic media, respectively) higher to that of a commercial reference with alumina carrier. According to shifts to higher binding energy of the Co 2p peak corresponding to sulfided cobalt (as determined by XPS), MoS 2 dispersed on NT support could be efficiently promoted by Co (“CoMoS” phase formation), opening the possibility of developing new highly active HDS catalysts.