Background The characteristics of people who volunteer as living organ donors have not been well delineated. Social capital perspectives offer unique insights to those who give altruistically. We examined the social networks of potential living kidney and liver donors who completed their preliminary medical donor work up and were scheduled for psycho-social consultation with our independent living donor advocate. Methods In our cross-sectional study, potential kidney and liver donors (n=48) were recruited from May 2016 to April 2017. Demographics were recorded (age, gender, marital status, state of residence, citizenship, socioeconomic status, and relationship of donor to recipient). Potential donors were asked about the frequency of contact with their families and the recipient, their perceived donor-recipient relationship post-donation, ethnicity and generation, native language spoken, family composition and their birth order, and self-care practices. Social capital variables included enrollment on Facebook/social media, physical activities/hobbies, whether they had children and/or pets, and engagement in spiritual practices. Results As shown in Table 1, mean donor age was 43±13, with 60% females. Our cohort was ethnically diverse, 17% and 24% being of Asian and Pacific Islander descent respectively. Most donors were biologically or emotionally related to their recipients, and 3 met on social media. All donors had at least a high school education; 33% had a bachelor’s degree or higher. 67% of donors were the eldest or youngest sibling. Only 7% were unemployed or retired. In terms of social capital, 77% were active on Facebook (median number of friends = 150), 69% had signed up to other social media platforms, 73% had a religious association, and 86% indicated frequent/very frequent contact with family members. Discussion In our diverse population, potential living organ donors had strong familial connections and social media usage. Spirituality, having a spouse, and a robust social network may guide someone toward the altruistic act of living donation. Social media may have a positive impact in promoting positive behavior (willingness to donate) through shared social capital (propagating social norms). Conventional psychosocial evaluation focuses on social support as a criterion for donation. Future work should explore the characteristics of someone’s social network to better understand the keys to a successful donor process. Pamela Derish, UCSF Department of Surgery, Scientific Publications Manager.