2nd ed, by Richard T. Johnson, 527 pp, with illus, Philadelphia, Pa, Lippincott-Raven Publishers, 1998.Viral Infections of the Nervous System (2nd edition) represents an excellent resource and leading reference in neurovirology. Professor Richard T. Johnson has updated this important textbook (published in 1998) and assimilated new findings and information following a 16-year interval since the 1st edition. As a single-author textbook, this work is easily readable, with continuity and a unified structure difficult to realize with multiauthored works. Professor Johnson's personal insights are interspersed throughout the book, insights that stem from his lifetime of investigations with multiple viral pathogens and provide valuable perspectives regarding the historical background of important discoveries. This reviewer strongly recommends this work as a highly readable and compact textbook.Viral Infections of the Nervous System is organized into 4 main sections entitled “General Principles,” “Acute Neurological Diseases,” “Chronic Neurological Diseases,” and “Other Perspectives.” In “General Principles,” basic principles of viral pathogenesis and host responses with special emphasis on the nervous system are described. In “Acute Neurological Diseases,” the pathogenesis of meningitis and encephalitis caused by multiple viruses, human herpesviruses, rabies, postinfectious demyelinating diseases, and postviral syndromes is discussed. New material abounds in the “Chronic Neurological Diseases” section regarding human and animal retroviruses, retroviral infections of the developing nervous system, and prion diseases. A thorough examination of chronic inflammatory and demyelinating diseases has been enhanced. The final section, entitled “Other Perspectives,” provides information difficult to find in other textbooks, such as discussions of oncogenesis in the nervous system and the nature of emerging viral infections. Recent concerns about West Nile Virus in the United States came after the publication of this book, and hence this encephalitis virus is only briefly described.The rapid development of neurovirology since the publication of the 1st edition 16 years ago has necessitated the addition of new chapters describing human retroviruses and postviral syndromes. New material regarding human herpesviruses, prion diseases, and viral infections of the developing nervous system has been incorporated in this updated edition. Sixteen years represents a lengthy period between editions, but few, if any, current books describe neurovirology in such a focused and thorough manner. General virology textbooks such as Fields Virology (Lippincott Williams & Wilkins) and Principles of Virology by Flint et al (ASM Press) provide alternative textbook sources for neurovirologists and students of infectious diseases. These alternatives represent excellent references in general virology, but they lack the uniquely focused approach in neurovirology. Viral Infections of the Nervous System provides a cohesive approach to neuropathogenesis by describing neuropathologic similarities of diseases caused by different viruses while emphasizing key differences in viral pathogenesis caused by related viruses. Johnson authoritatively describes the historical context of important discoveries. Importantly, this book is not a complete reference for the diagnosis and therapy of viral infections, although these subjects are addressed briefly. Other resources, such as the Manual of Clinical Microbiology (ASM Press) and medical textbooks of infectious diseases, represent more comprehensive references for the diagnosis and treatment of diseases in medical virology.Viral Infections of the Nervous System deserves an emphatic recommendation to medical and graduate students, physicians, and virologists. This book accomplishes its goal of providing a stand-alone reference for neurovirology and viral pathogenesis of the human nervous system. All major areas of neurovirology and prion diseases are included in this textbook. The cohesive presentation of a single-author work and the personal insights of a highly respected figure in the field lend additional value to this reference. Although neurovirology is rapidly expanding with applications of molecular biology, basic principles of pathogenesis are elegantly described and provide a durable framework for further studies. I hope that a 3rd edition will be published after a shorter time interval, and I congratulate Professor Johnson on an outstanding contribution to the virologic literature.
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