Alternative Platform Research Articles

Personalization of lipid-based oral dosage forms via filament-based 3D-printing

While filament-based 3D-printing (3DP) is the most utilized 3DP technology in the pharmaceutical field, it has not been demonstrated for processing of drug-loaded lipid-based formulations. This work exploits hexa-glycerol ester of palmitic acid (Pg6-C16-P) as an advanced lipid material, loaded with felodipine as a poorly soluble model drug, for fabricating novel oral solid dosage forms (OSDFs) via filament-based 3D-printing. After material melt-blending, the formulation was extruded using the liquid feeding approach to obtain a mechanically manageable, and hence 3D-printable, drug-loaded lipid filament. The fabrication of geometries with variable infill densities was demonstrated. The extent of infill density was found to significantly impact the optimal printing parameters required to achieve the desired shape. The solid-state analysis confirmed the amorphous state of felodipine after 3DP. The release rate of the drug was studied via in vitro dissolution test and showed to be tunable based on the tablet geometry. It was also possible to tailor the design of the dosage form to perform similarly to a commercial product. The formulation was evidenced as safe via in vitro toxicity studies with improved felodipine solubility. This study establishes filament-based 3DP as an alternative platform viable for fabricating advanced lipid-based OSDFs, and concurrently, promotes Pg6-C16-P as a promising and high performing 3DP lipid material for drug delivery.

Interaction Effects on the Dynamical Anderson Metal-Insulator Transition Using Kicked Quantum Gases.

Understanding the interplay of interaction and disorder in quantum transport poses long-standing scientific challenges for theory and experiment. While highly controlled ultracold atomic platforms combining atomic interactions with spatially disordered lattices have led to remarkable advances, the extension of such controlled studies to phenomena in high-dimensional disordered systems, such as the three-dimensional Anderson metal-insulator transition has been limited. Kicked quantum gases provide an alternate experimental platform that captures the Anderson model in momentum space and features dynamical localization as the analog of Anderson localization. Here, we utilize a momentum space lattice platform using quasiperiodically kicked ultracold atomic gases to experimentally investigate interaction effects on the three-dimensional dynamical Anderson metal-insulator transition. We observe interaction-driven subdiffusion and a divergence of delocalization onset time on approaching the phase boundary. Mean-field numerical simulations show qualitative agreement with experimental observations, but with significant quantitative deviations.

Fatigue resistant photo-responsive [c2] daisy chain Poly(rotaxane) hydrogel

A photo-responsive poly(rotaxane) hydrogel based on [c2] daisy chain was synthesized. The supramolecular hydrogel was robust with the compression stress of 3136 kPa at the strain of 90 %, the tensile strength of 297 kPa and the elongation at break of 694 %. At the same time, the gel film showed fast photoresponsive behavior even in dry state, showing 15o bending angle under 2 s 365 nm UV irradiation. Besides, the hydrogel exhibited good fatigue resistance. Its recovery ratio remains higher than 80 % during multiple cyclic tensile and compression test, making it an alternative and promising platform for photo-responsive materials with emergent mechanical performances and attractive fatigue resistance.

Majorana modes in striped two-dimensional inhomogeneous topological superconductors

Majorana zero modes have gained significant interest due to their potential applications in topological quantum computing and in the realization of exotic quantum phases. These zero-energy quasiparticle excitations localize at the vortex cores of two-dimensional topological superconductors or at the ends of one-dimensional topological superconductors. Here we describe an alternative platform: a two-dimensional topological superconductor with inhomogeneous superconductivity, where Majorana modes localize at the ends of topologically nontrivial one-dimensional stripes induced by the spatial variations of the order parameter phase. In certain regimes, these Majorana modes hybridize into a single highly nonlocal state delocalized over spatially separated points, with exactly zero energy at finite system sizes and with emergent quantum-mechanical supersymmetry. We then present detailed descriptions of braiding and fusion protocols and showcase the versatility of our proposal by suggesting possible setups that can potentially lead to the realization of Yang-Lee anyons and the Sachdev-Ye-Kitaev model.

Survival and growth of M. perstans larvae in a human colon carcinoma cell line-based in vitro culture

Mansonella perstans infections are widespread in Sub-Saharan Africa and Central and South America and thus can be considered as the most prevalent parasite of man in tropical Africa. In contrast to the high prevalence, knowledge about the biology of this filarial nematode is restricted and no effective treatment regimens of this ivermectin-resistant parasite is lacking. An obstacle for the research is that M. perstans resides in body cavities and thus have been only rarely recovered during surgery or autopsy. Therefore, alternative methods like in vitro culture systems need to be implemented to decipher the nature of mansonellosis and effective drugs. Previously, we have established a monkey kidney epithelial cell-based in vitro culture for the maintenance of M. perstans infective larvae (L3) up to 77 days. However, no alternative for this culture system have been postulated to allow longer survival rates and development of adult worms in vitro. Thus, we aim to establish an alternative in vitro culture system for M. perstans L3. M. perstans L3 were isolated from engorged and laboratory reared Culicoides midges. The larvae were then cultured in Dulbecco's Modified Eagle Medium supplemented with either 10% foetal bovine serum (FBS), 10% newborn calf serum (NCS) or 1% bovine serum albumin (BSA) together with human colon carcinoma cells (HCT-8) as feeder cells. Survival and growth were recorded. We obtained that the 10% NCS culture condition was superior allowing long-term maintenance of M. perstans L3 for up to 100 days and boosted growth of the parasites for up to 5-folds compared to the initial size at culture inception. Although no moulting of the L3 into L4 or adult worms could be overserved, the human colon carcinoma cell-based in vitro culture provides an alternative platform to analyse M. perstans biology and screen for novel drugs against M. perstans.

Micro-Nanostructured Polymeric Scaffolds for Bone Tissue Engineering

While bone tissue allograft and autograft are commonly used in bone healing, their application is limited by factors such as availability, donor site morbidity, and immune response to the grafted tissue. Tissue-engineered implants, such as acellular or cellular polymeric structures, offer a promising alternative, and are a current trend in tissue engineering. Leveraging recent advancements in bone tissue engineering (BTE), we utilize 3D printing to develop biodegradable scaffolds that combine mechanical strength and bioactivity to facilitate bone repair and regeneration. This study focuses on the design and fabrication of mechanically competent 3D printed poly (L-lactic acid) (PLLA) micro-structured scaffolds. These scaffolds are enhanced with collagen type I nanofibrils to create bioactive scaffolds that promote tissue regeneration. The performance of these mechanically competent, micro-nanostructured polymeric matrices, in combination with bone marrow stromal cells (BMSCs), is evaluated in PLLA and PLLA-collagen scaffolds. The resulting micro-nanostructured PLLA-Collagen scaffolds mimic trabecular bone architecture, mechanical strength, and the extracellular matrix environment found in native bone tissue. The composite PLLA-collagen scaffolds exhibit mechanical properties in the mid-range of human trabecular bone. Both PLLA and PLLA-Collagen scaffolds support human BMSCs adhesion, proliferation, and osteogenic differentiation. A significantly higher number of implanted host cells are distributed in the PLLA-Collagen scaffolds with greater bone density, more uniform cell distribution, and attachment compared to the PLLA microstructure. Additionally, the biomimetic collagen nanostructure potently induces osteogenic transcription evidenced by increased alkaline phosphatase activity and upregulation of bone markers such as sialoprotein and collagen type I, ultimately guiding stem cell-mediated formation of a mature, mineralized bone matrix throughout the interconnected scaffold pores. This study underscores the benefits of micro-nanostructured scaffolds in successfully generating the inductive microenvironment of native bone extracellular matrix, triggering the cascade of cellular events required for functional bone regeneration, repairing critical-sized bone defects, and ultimately serving as an alternative material platform for bone regeneration, thereby instilling confidence in the potential of our research.

Evaluation of high-fidelity and virtual reality simulation platforms for assessing fourth-year medical students’ encounters with patients in need of urgent or emergent care

Background Medical students in the U.S. must demonstrate urgent and emergent care competence before graduation. Urgent and emergent care competence involves recognizing, evaluating and initiating management of an unstable patient. High-fidelity (HF) simulation can improve urgent and emergent care skills, but because it is resource intense, alternative methods are needed. Study Objective Our primary purpose was to use program evaluations to compare medical student experiences with HF and virtual reality (VR) simulations as assessment platforms for urgent and emergent care skills. Methods During their emergency medicine clerkship, students at The Ohio State University College of Medicine must demonstrate on HF manikins, competence in recognizing and initiating care of a patient requiring urgent or emergent care. Students evaluated these simulations on a five-point quality scale and answered open-ended questions about simulation strengths and weaknesses. Faculty provided feedback on student competence in delivering urgent or emergent care. In 2022, we introduced VR as an alternative assessment platform. We used Wilcoxon Signed Ranks and Boxplots to compare ratings of HF to VR and McNemar Test to compare competence ratings. Comments were analyzed with summative content analysis or thematic coding. Results We received at least one evaluation survey from 160 of 216 (74.1%) emergency medicine clerkship students. We were able to match 125 of 216 (57.9%) evaluation surveys for students who completed both. Average ratings of HF simulations were 4.6 of 5, while ratings of VR simulations were slightly lower at 4.4. Comments suggested that feedback from both simulation platforms was valued. Students described VR as novel, immersive, and good preparation for clinical practice. Constructive criticism identified the need for additional practice in the VR environment. Student performance between platforms was significantly different with 91.7% of students achieving competence in HF, but only 65.5% in VR (p≤.001, odds-ratio = 5.75). Conclusion VR simulation functions similarly to HF for formative assessment of urgent and emergent care competence. However, using VR simulation for summative assessment of urgent and emergent care competence must be considered with caution because students require considerable practice and acclimation to the virtual environment.

Extracellular Vesicles from Nanomedicine-Trained Intestinal Microbiota Substitute for Fecal Microbiota Transplant in Treating Ulcerative Colitis.

The biosafety concerns associated with fecal microbiota transplant (FMT) limit their clinical application in treating ulcerative colitis (UC). Gut microbiota secrete abundant extracellular vesicles (Gm-EVs), which play a critical role in bacteria-to-bacteria and bacteria-to-host communications. Herein, intestinal microbiota are trained using tea leaf lipid/pluronic F127-coated curcumin nanocrystals (CN@Lp127s), which can maintain stability during transit through the gastrointestinal tract. Compared with FMT, Gm-EVs derived from healthy mice significantly improve treatment outcomes against UC by reducing colonic inflammatory responses, restoring colonic barrier function, and rebalancing intestinal microbiota. Strikingly, Gm-EVs obtained from CN@Lp127-trained healthy mice exhibit a superior therapeutic effect on UC compared to groups receiving FMT from healthy mice, Gm-EVs from healthy mice, and FMT from CN@Lp127-trained healthy mice. Oral administration of Gm-EVs from CN@Lp127-trained healthy mice not only alleviates colonic inflammation, promotes mucosal repair, and regulates gut microbiota but also regulates purine metabolism to decrease the uric acid level, resulting in a robust improvement in the UC. This study demonstrates the UC therapeutic efficacy of Gm-EVs derived from nanomedicine-trained gut microbiota in regulating the immune microenvironment, microbiota, and purine metabolism of the colon. These EVs provide an alternative platform to replace FMT as a treatment for UC.

A flexible non-enzymatic hydrogel-assisted electrochemical sensor: Wireless, sensitive, and selective uric acid detection for home monitoring

A smartphone-enabled, wireless, and battery-free electrochemical sensor equipped with electroactive poly (3,4-ethylenedioxythiophene):poly(styrenesulfonate)/polyvinyl alcohol (PEDOT:PSS/PVA) hydrogel composites, was developed for the non-enzymatic assessment of uric acid (UA) concentrations in human serum and wound exudate. The sensor was constructed with the aid of simple and sustainable modification techniques, such as drop-casting and crosslinking via a green freezing–thawing protocol. Gold nanoparticles (AuNPs) and the PEDOT:PSS/PVA electroactive hydrogel were employed to increase the surface area of the sensor and sample interactions, which improved the sensitivity and specificity for UA detection in the clinical range of 10–1,000 µM, with a detection limit of 0.05 mg/dL in addition to biocompatibility (L-929 cell viability > 90 %). In human serum and wound exudate samples, the prepared sensor demonstrated a good correlation for UA detection when compared to ISO15189 accredited medical laboratory measurements (Pearson correlation coefficient (r) = 0.97 and r = 0.98, respectively). The UA sensor was integrated with the flexible near field communication (NFC) circuit, and demonstrated the feasibility of measuring UA in human serum and wound exudate with results that were consistent with uricase enzymatic determination (p-value > 0.05). The sensor’s wearability was demonstrated by a recovery rate of 101–109 % UA detection when bending on the IV training arm. This NFC UA sensing device can serve as a good alternative platform for self–UA monitoring, along with the potential for developing a smart wound dressing for wound management.

Is social media a helpful communicative tool in combatting corruption in developing countries? Evidence from Ghana

The traditional mainstream media is often considered part of the capital and power network involved in corruption, casting doubt on the traditional media’s watchdog functions. This study examines whether social media can be a positive communicative tool for addressing corruption, especially in developing countries such as Ghana. Drawing on in-depth semi-structured interviews and relevant secondary data, Habermas’s theory of the public sphere, and the notion of citizen journalism as a form of social accountability, the study addresses key questions: As a communicative platform/tool, does social media provide utility toward the fight against corruption? In what ways does social media support or undermine the fight against corruption? Findings indicate that social media is a valuable communicative instrument for combating corruption. It offers an alternative platform for exposing corruption; naming and shaming offenders; and mobilizing, organizing, protesting, and demanding accountability. Nevertheless, the study reveals that social media routinely spreads fake news, propaganda, and misinformation, undermining its credibility as an effective anti-corruption communicative tool. This article contributes to the debate on whether social media is a valuable communicative tool in the fight against corruption, especially in the developing country context.

The Effect of Using Learning Management System Learning Media on Student Independence and Learning Outcomes

In the learning process, good student learning motivation is created by the use of engaging learning media. When students become motivated, it will enhance their independence in learning, which in turn will lead to better learning outcomes. This research aims to conduct a literature review to explore the influence of using Learning Management Systems (LMS) on students' independence and learning outcomes. Additionally, the study seeks to identify alternative LMS platforms besides Moodle, Edmodo, and Google Classroom, which are widely used among educators in Indonesia. The research employs the Systematic Literature Review (SLR) method, which aims to identify, assess, and interpret all evidence from previous studies to find solutions to existing problems. The data collected from this research indicate that e-learning using LMS has been proven to enhance students' academic achievement and learning independence. Apart from Edmodo, Moodle, and Google Classroom, there are many other LMS platforms that educators can explore, such as Canvas LMS, which is equally attractive as other LMS platforms

Enhanced efficacy of glycoengineered rice cell-produced trastuzumab.

For several decades, a plant-based expression system has been proposed as an alternative platform for the production of biopharmaceuticals including therapeutic monoclonal antibodies (mAbs), but the immunogenicity concerns associated with plant-specific N-glycans attached in plant-based biopharmaceuticals has not been completely solved. To eliminate all plant-specific N-glycan structure, eight genes involved in plant-specific N-glycosylation were mutated in rice (Oryza sativa) using the CRISPR/Cas9 system. The glycoengineered cell lines, PhytoRice®, contained a predominant GnGn (G0) glycoform. The gene for codon-optimized trastuzumab (TMab) was then introduced into PhytoRice® through Agrobacterium co-cultivation. Selected cell lines were suspension cultured, and TMab secreted from cells was purified from the cultured media. The amino acid sequence of the TMab produced by PhytoRice® (P-TMab) was identical to that of TMab. The inhibitory effect of P-TMab on the proliferation of the BT-474 cancer cell line was significantly enhanced at concentrations above 1 μg/mL (****P < 0.0001). P-TMab bound to a FcγRIIIa variant, FcγRIIIa-F158, more than 2.7 times more effectively than TMab. The ADCC efficacy of P-TMab against Jurkat cells was 2.6 times higher than that of TMab in an in vitro ADCC assay. Furthermore, P-TMab demonstrated efficient tumour uptake with less liver uptake compared to TMab in a xenograft assay using the BT-474 mouse model. These results suggest that the glycoengineered PhytoRice® could be an alternative platform for mAb production compared to current CHO cells, and P-TMab has a novel and enhanced efficacy compared to TMab.

Manipulating Light with Bound States in the Continuum: from Passive to Active Systems

AbstractThe manipulation of light has become the focus of various modern optical technologies. The emergence of bound states in the continuum (BICs) offers an alternative platform for controlling light, including the confinement and manipulation of polarization, amplitude, and phase. Currently, research on photonic BICs is maturing, with extensive exploration of methods for achieving BICs and their various applications, including lasing, sensing, and enhanced light‐matter interaction. In this review, an overview of photonic BICs is provided. Specifically, the unique properties of BICs are first presented, followed by their state‐of‐the‐art applications in passive systems, ranging from sensing to waveguiding, beam shaping, and chirality. The paradigm‐shifting developments in active systems resulting from the hybridization of BICs with active and novel materials are then highlighted. Finally, some of the challenges facing photonic BICs are discussed, along with future directions in terms of physics, design, fabrication, engineering, and tunability.

Chimeric antigen receptor adoptive immunotherapy in central nervous system tumors: state of the art on clinical trials, challenges, and emerging strategies to addressing them.

Central nervous system (CNS) tumors represent a significant unmet medical need due to their enduring burden of high mortality and morbidity. Chimeric antigen receptor (CAR) T-cell therapy emerges as a groundbreaking approach, offering hope for improved treatment outcomes. However, despite its successes in hematological malignancies, its efficacy in solid tumors, including CNS tumors, remains limited. Challenges such as the intricate tumor microenvironment (TME), antigenic heterogeneity, and CAR T-cell exhaustion hinder its effectiveness. This review aims to explore the current landscape of CAR T-cell therapy for CNS tumors, highlighting recent advancements and addressing challenges in achieving therapeutic efficacy. Innovative strategies aim to overcome the barriers posed by the TME and antigen diversity, prevent CAR T-cell exhaustion through engineering approaches and combination therapies with immune checkpoint inhibitors to improving treatment outcomes. Researchers have been actively working to address these challenges. Moreover, addressing the unique challenges associated with neurotoxicity in CNS tumors requires specialized management strategies. These may include the development of grading systems, monitoring devices, alternative cell platforms and incorporation of suicide genes. Continued research efforts and clinical advancements are paramount to overcoming the existing challenges and realizing the full potential of CAR T-cell therapy in treating CNS tumors.

The political, psychological, and social correlates of cryptocurrency ownership.

Cryptocurrency is a digital asset secured by cryptography that has become a popular medium of exchange and investment known for its anonymous transactions, unregulated markets, and volatile prices. Given the popular subculture of traders it has created, and its implications for financial markets and monetary policy, scholars have recently begun to examine the political, psychological, and social characteristics of cryptocurrency investors. A review of the existing literature suggests that cryptocurrency owners may possess higher-than-average levels of nonnormative psychological traits and exhibit a range of non-mainstream political identities. However, this extant literature typically employs small nonrepresentative samples of respondents and examines only a small number of independent variables in each given study. This presents the opportunity for both further testing of previous findings as well as broader exploratory analyses including more expansive descriptive investigations of cryptocurrency owners. To that end, we polled 2,001 American adults in 2022 to examine the associations between cryptocurrency ownership and individual level political, psychological, and social characteristics. Analyses revealed that 30% of our sample have owned some form of cryptocurrency and that these individuals exhibit a diversity of political allegiances and identities. We also found that crypto ownership was associated with belief in conspiracy theories, "dark" personality characteristics (e.g., the "Dark Tetrad" of narcissism, Machiavellianism, psychopathy, and sadism), and more frequent use of alternative and fringe social media platforms. When examining a more comprehensive multivariate model, the variables that most strongly predict cryptocurrency ownership are being male, relying on alternative/fringe social media as one's primary news source, argumentativeness, and an aversion to authoritarianism. These findings highlight numerous avenues for future research into the people who buy and trade cryptocurrencies and speak to broader global trends in anti-establishment attitudes and nonnormative behaviors.

Development of ternary hybrid composites of transition metal and noble metal-based heterostructures: Ultrasensitive simultaneous electrochemical detection of bisphenol A and bisphenol S in food samples

Bisphenols threaten human health and sensitive detection is crucial. The present study aims to develop ternary composites of copper metal-organic framework (Cu-MOF) with AuAg microstructures. The composite structure was formed by a galvanic displacement reaction and confirmed using SEM. A binder-free catalyst was used to study the electrochemical redox reaction of bisphenol A (BPA) and bisphenol S (BPS); an irreversible cyclic voltammetric signal at +0.70 V and + 0.91 V (vs. Ag/AgCl), in the dynamic range of 20 nM to 2.0 mM, and 10 nM to 1.0 mM, with limits of detection of 2.9 nM, and 3.2 nM (S/N = 3) was obtained. Practical analysis was applied to frozen tomatoes, tuna fish, milk powder, PET bottles, raw milk, and urine samples with a recovery rate of 94.00–100.80% (n = 3). Voltammetric results were validated using HPLC detection with high precision. The sensor is a promising alternative platform for measuring BPA in food samples.

Operation of the Russian Aerospace Forces in Syria in the Official Russian Discourse

Abstract In this article, we analyze how the operation of the Russian Aerospace forces is presented in the official Russian discourse. The analysis is based on a collected database of statements made by the Russian authorities. Relying on social identity theory, we argue that the Russian operation in Syria became a key element in changing the Russian strategy in the Middle East. In other words, beginning in the mid-2010s, Russian policy in the Middle East moved from social competition to social creativity. Taking the Russian operation in Syria as an example, we assert that the second half of 2017 was a turning point because the military narration of the discourse was replaced at that point with the narration of the unique role of Russia in the regulation of the Syrian conflict. This narration included narratives related to ‘sovereignty’, ‘territorial integrity’, and the creation of alternative platforms to maintain stability.

Spatially Resolved Near Field Spectroscopy of Vibrational Polaritons at the Small N Limit.

Vibrational polaritons, which have been primarily studied in Fabry-Pérot cavities with a large number of molecules (N ∼ 106-1010) coupled to the resonator mode, exhibit various experimentally observed effects on chemical reactions. However, the exact mechanism is elusively understood from the theoretical side, as the large number of molecules involved in an experimental strong coupling condition cannot be represented completely in simulations. This discrepancy between theory and experiment arises from computational descriptions of polariton systems typically being limited to only a few molecules, thus failing to represent the experimental conditions adequately. To address this mismatch, we used surface phonon polariton (SPhP) resonators as an alternative platform for vibrational strong coupling. SPhPs exhibit strong electromagnetic confinement on the surface and thus allow for coupling to a small number of molecules. As a result, this platform can enhance nonlinearity and slow down relaxation to the dark modes. In this study, we fabricated a pillar-shaped quartz resonator and then coated it with a thin layer of cobalt phthalocyanine (CoPc). By employing scattering-type scanning near-field optical microscopy (s-SNOM), we spatially investigated the dependency of vibrational strong coupling on the spatially varying electromagnetic field strength and demonstrated strong coupling with 38,000 molecules only-reaching to the small N limit. Through s-SNOM analysis, we found that strong coupling was observed primarily on the edge of the quartz pillar and the apex of the s-SNOM tip, where the maximum field enhancement occurs. In contrast, a weak resonance signal and lack of coupling were observed closer to the center of the pillar. This work demonstrates the importance of spatially resolved polariton systems in nanophotonic platforms and lays a foundation to explore polariton chemistry and chemical dynamics at the small N limit-one step closer to reconcile with high-level quantum calculations.

Prebunking earthquake predictions on social media

Earthquake misinformation has not only a significant impact on crisis management, but also on trust in scientific information and institutions. As a global center for seismic information, the Euro-Mediterranean Seismological Center (EMSC) has developed a strategy to combat false information related to earthquakes, particularly on Twitter (now known as X). This strategy includes the automation of prebunking tweets to prevent the spread of false information and, particularly unreliable claims of earthquake predictions. In the field of false information, predictions of earthquakes have a particular characteristic: their appearance follows a specific dynamic and the attention paid to them is predictable, which makes the automation of countermeasures (prebunking and debunking) both possible and relevant. Therefore, the objectives of the EMSC’s automatic tweets are to warn people in advance, particularly those who may be vulnerable to earthquake misinformation, while filling the information void with verified, scientifically-based information in the meantime. This paper seeks to examine the usefulness of such a tool. It does so by analyzing users’ engagement with these tweets. In addition, it focuses on two case studies, the seismic sequence in Turkey following the M7.8 earthquake on February 6, 2023 and the M6.8 Morocco earthquake on September 8, 2023. The results show engagement with the automatically generated tweets but an even greater interaction and engagement with manual tweets, highlighting the importance of a holistic approach. Recommendations include optimizing the visibility of the tweets, extending efforts beyond social media, and exploring alternative platforms. The paper advocates for a comprehensive strategy, combining automated tools with manual engagement and leveraging diverse communication channels to take into account cultural differences.

News Censorship and the Practice of Citizen Journalism

This study delves into the relationship between news censorship and citizen journalism within the contemporary media landscape. It scrutinizes how news censorship, encompassing government intervention and self-censorship by media entities, impacts transparency and freedom of expression. In response to these constraints, citizen journalism emerges as a vital alternative platform for information dissemination, especially in authoritarian contexts. However, citizen journalism encounters hurdles such as the absence of formal training and the inherent risks associated with independent reporting. Nonetheless, despite these challenges, citizen journalism serves as a potent counterforce to censorship, empowering individuals to share suppressed information and shape public discourse. Through comprehensive analysis, the study underscores the pivotal role of citizen journalism in circumventing censorship and offering diverse perspectives. Yet, it also brings to light the imperative need for enhanced training and support mechanisms to bolster the quality and credibility of citizen journalism. Ultimately, the study concludes that safeguarding freedom of expression and fostering support for citizen journalism are indispensable for nurturing transparency and democratic discourse. To this end, To this end, the study advocates for comprehensive initiatives aimed at bolstering citizen journalism. These include not only providing ample training resources to equip citizen journalists with the necessary skills and knowledge but also facilitating robust collaboration between them and traditional media outlets. Such collaboration can foster mutual understanding, enhance the exchange of information, and strengthen the overall quality of reporting.