Alternative Definitions Research Articles

Economic Determinants of Financial Service Accessibility

This study investigates the influence of economic factors in ensuring access to financial services. Financial service accessibility is assessed using metrics such as the number of bank branches and ATMs per 100,000 people, as well as an index derived from these indicators. Drawing from existing literature, a set of economic variables - namely, employment, inflation, gross domestic savings, remittances, bank credit to deposits, and urbanization - are examined using data from 179 countries over eighteen years spanning from 2004 to 2021, with projections extending to 2023. The findings indicate that employment, remittances, bank credit to deposits, and urbanization exert statistically significant effects on access to financial services. These results are robust across alternative definitions of financial access, subsamples categorised by economic development, and exercises addressing endogeneity concerns.

Consumption of Sugar-Sweetened Beverages before 2 Years of Age and Attention-Deficit/Hyperactivity Disorder

Introduction: This study examined the association between sugar-sweetened beverage consumption before the first 24 months of life and attention-deficit/hyperactivity disorder (ADHD). Methods: A population administrative cohort study was conducted in Korea (2008–2019) using linked national insurance data and a health screening survey. The cohort included 25,305 children in the exposed group with high sugar-sweetened beverage drinks (≥200 mL) and 339,931 in the reference groups (<200 mL) at 24 months of age. The primary outcome was the development of ADHD based on the International Classification of Disease (ICD) codes. Cox proportional model was used to identify the association between sugar-sweetened beverage consumption during early childhood and the later development of ADHD while controlling for multiple risk factors. Results: Over a mean follow-up period of 9.2 years, the incidence rates of ADHD were 29.6 and 23.8 per 10,000 person-years in the exposed and reference groups, respectively. Compared with the reference group, children consuming high-sugar drinks were at an increased risk of ADHD (adjusted hazard ratio 1.17, 95% confidence interval [CI] 1.08–1.27). These associations remained significant even after applying alternative ADHD definitions or adjusting for confounding variables. Conclusion: Children who consume sweetened beverages during early childhood are at increased risk of developing ADHD later in life.

Preterm and Early-Term Delivery After Heat Waves in 50 US Metropolitan Areas

Heat waves are increasing in frequency, intensity, and duration and may be acutely associated with pregnancy outcomes. To examine changes in daily rates of preterm and early-term birth after heat waves in a 25-year nationwide study. This cohort study of singleton births used birth records from 1993 to 2017 from the 50 most populous US metropolitan statistical areas (MSAs). The study included 53 million births, covering 52.8% of US births over the period. Data were analyzed between October 2022 and March 2023 at the National Center for Health Statistics. Daily temperature data from Daymet at 1-km2 resolution were averaged over each MSA using population weighting. Heat waves were defined in the 4 days (lag, 0-3 days) or 7 days (lag, 0-6 days) preceding birth. Daily counts of preterm birth (28 to <37 weeks), early-term birth (37 to <39 weeks), and ongoing pregnancies in each gestational week on each day were enumerated in each MSA. Rate ratios for heat wave metrics were obtained from time-series models restricted to the warm season (May to September) adjusting for MSA, year, day of season, and day of week, and offset by pregnancies at risk. There were 53 154 816 eligible births in the 50 MSAs from 1993 to 2017; 2 153 609 preterm births and 5 795 313 early-term births occurring in the warm season were analyzed. A total of 30.0% of mothers were younger than 25 years, 53.8% were 25 to 34 years, and 16.3% were 35 years or older. Heat waves were positively associated with daily rates of preterm and early-term births, showing a dose-response association with heat wave duration and temperatures and stronger associations in the more acute 4-day window. After 4 consecutive days of mean temperatures exceeding the local 97.5th percentile, the rate ratio for preterm birth was 1.02 (95% CI, 1.00-1.03), and the rate ratio for early-term birth was 1.01 (95% CI, 1.01-1.02). For the same exposure, among those who were 29 years of age or younger, had a high school education or less, and belonged to a racial or ethnic minority group, the rate ratios were 1.04 (95% CI, 1.02-1.06) for preterm birth and 1.03 (95% CI, 1.02-1.05) for early-term birth. Results were robust to alternative heat wave definitions, excluding medically induced deliveries, and alternative statistical model specifications. In this cohort study, preterm and early-term birth rates increased after heat waves, particularly among socioeconomically disadvantaged subgroups. Extreme heat events have implications for perinatal health.

A Note on Weakly Semiprime Ideals and Their Relationship to Prime Radical in Noncommutative Rings

In this paper, we introduce the concept of weakly semiprime ideals and weakly n-systems in noncommutative rings. We establish the equivalence between an ideal P being a weakly semiprime ideal and R−P being a weakly n-system. We provide alternative definitions and explore the properties of weakly semiprime ideals. Additionally, we investigate scenarios where all ideals in a given ring are weakly semiprime and demonstrate that in Noetherian rings, where every ideal is weakly semiprime, the prime radical and the Jacobson radical coincide.

Characterizing genetic profiles for high triglyceride levels in U.S. patients of African ancestry

Hypertriglyceridemia (HTG) is a common cardiovascular risk factor characterized by elevated triglyceride (TG) levels. Researchers have assessed the genetic factors that influence HTG in studies focused predominantly on individuals of European ancestry. However, relatively little is known about the contribution of genetic variation of HTG in people of African ancestry (AA), potentially constraining research and treatment opportunities. Our objective was to characterize genetic profiles among individuals of AA with mild-to-moderate HTG and severe HTG versus those with normal TGs by leveraging whole-genome sequencing data and longitudinal electronic health records available in the All of Us program. We compared the enrichment of functional variants within five canonical TG metabolism genes, an AA-specific polygenic risk score for TGs, and frequencies of 145 known potentially causal TG variants between HTG patients and normal TG among a cohort of AA patients (N = 15,373). Those with mild-to-moderate HTG (N = 342) and severe HTG (N ≤ 20) were more likely to carry APOA5 p.S19W (odds ratio = 1.94, 95% confidence interval = [1.48–2.54], P = 1.63 × 10−6 and OR = 3.65, 95% confidence interval: [1.22–10.93], P = 0.02, respectively) than those with normal TG. They were also more likely to have an elevated (top 10%) polygenic risk score, elevated carriage of potentially causal variant alleles, and carry any genetic risk factor. Alternative definitions of HTG yielded comparable results. In conclusion, individuals of AA with HTG were enriched for genetic risk factors compared to individuals with normal TGs.

Estimating the size and scope of the academic emergency physician workforce.

Academic emergency medicine (EM) is foundational to the EM specialty through the development of new knowledge and clinical training of resident physicians. Despite recent increased attention to the future of the EM workforce, no evaluations have specifically characterized the U.S. academic EM workforce. We sought to estimate the national proportion of emergency physicians (EPs) identified as academic and the proportion of emergency department (ED) visits that take place at academic sites. We performed a cross-sectional analysis of EPs and EDs using data from the American Hospital Association, the Centers for Medicare & Medicaid Services, and Doximity's Residency Navigator. EPs were identified as "academic" if they were affiliated with at least one facility determined to be academic, defined as EDs officially designated by the Accreditation Council for Graduate Medical Education (ACGME) as clinical training sites at accredited EM residency programs. Our primary outcomes were to estimate the national proportion of EPs identified as academic and the proportion of ED visits performed at academic sites. Our analytic sample included 26,937 EPs practicing clinically across 4920 EDs and providing care during 130,471,386 ED visits. Among EPs, 11,720 (43.5%) were identified as academic, and among EDs, 635 (12.9%) were identified as academic sites, including 585 adult/general sites, 45 pediatric-specific sites, and 10 sites affiliated with the Department of Veterans Affairs. In 2021, academic EDs provided care for 42,794,106 ED visits or 32.8% of all ED visits nationally. Approximately four in 10 EPs practice in at least one clinical training site affiliated with an ACGME-accredited EM residency program, and approximately one in three ED visits nationally occur in these academic EDs. We encourage further work using alternative definitions of an academic EPs and EDs, along with longitudinal research to identify trends in the workforce's composition.

Assessing the functional impact of protein binding site definition.

Many biomedical applications, such as classification of binding specificities or bioengineering, depend on the accurate definition of protein binding interfaces. Depending on the choice of method used, substantially different sets of residues can be classified as belonging to the interface of a protein. A typical approach used to verify these definitions is to mutate residues and measure the impact of these changes on binding. Besides the lack of exhaustive data, this approach also suffers from the fundamental problem that a mutation introduces an unknown amount of alteration into an interface, which potentially alters the binding characteristics of the interface. In this study we explore the impact of alternative binding site definitions on the ability of a protein to recognize its cognate ligand using a pharmacophore approach, which does not affect the interface. The study also shows that methods for protein binding interface predictions should perform above approximately F-score = 0.7 accuracy level to capture the biological function of a protein.

Does cap-and-trade scheme impact energy efficiency and firm value? Empirical evidence from India

Governments worldwide have adopted environmental regulations to fight global warming. In 2012, the Government of India introduced the Perform, Achieve and Trade (PAT), a cap-and-trade scheme, to achieve energy efficiency for large-sized industries. The extant literature is divided on the impacts of environmental regulations on firm performance. While the win-win argument of Porter and Van der Linde (1991) proposes a positive effect, the cost-regulation theory suggests a negative impact. Against this backdrop, we examine the impact of the PAT scheme on energy efficiency and firm value. As an identification strategy, we employ difference-in-differences (DID) combined with propensity score matching methods on firm level data from 2006 to 2015. We do not find evidence of a statistically significant impact of the PAT scheme on firms' energy efficiency. In contrast, our results suggest that the scheme adversely affects firm value. Furthermore, we find that increased expenditure on repair and maintenance, research and development, rising plant and machinery purchases, and a fall in productivity are the potential channels through which the PAT scheme impacts firm value. Our results are robust to alternative definitions of energy intensity, firm value, and empirical specifications.

Accounting for nuclear and mito genome in dairy cattle breeding - a simulation study

Mitochondria play a significant role in numerous cellular processes through proteins encoded by both the nuclear genome (nDNA) and mito genome (mDNA), and increasing evidence shows that traits of interest might be affected by mito-nuclear interactions. While the variation in nDNA is influenced by mutations and recombination of parental genomes, the variation in mDNA is solely driven by mutations. In addition, mDNA is inherited in a haploid form, from the dam. Cattle populations show significant variation in mDNA between and within breeds. Past research suggests that variation in mDNA accounts for 1–5% of the phenotypic variation in dairy traits. Here we simulated a dairy cattle breeding program to assess the impact of accounting for mDNA variation in pedigree-based and genome-based genetic evaluations on the accuracy of estimated breeding values for mDNA and nDNA components. We also examined the impact of alternative definitions of breeding values on genetic gain, including nDNA and mDNA components that both impact phenotype expression, but mDNA is inherited only maternally. We found that accounting for mDNA variation increased accuracy between +0.01 and +0.03 for different categories of animals, especially for young bulls (+0.03) and females without genotype data (between +0.01 and +0.03). Different scenarios of modeling and breeding value definition impacted genetic gain. The standard approach of ignoring mDNA variation achieved competitive genetic gain. Modeling, but not selecting on mDNA expectedly reduced genetic gain, while optimal use of mDNA variation recovered the genetic gain.

Exploring the implications of ‘no net land take’ policy for spatial planning: the case of the Netherlands

The European Union’s ‘no net land take’ (NNLT) target, which seeks to halt greenfield development by 2050, is very pertinent for planners. The present article investigates its potential impact with special attention for the Netherlands. Given that no single definition or methodology had been established at the EU level, land take was calculated over the 2000–2018 period for alternative definitions. A result is that qualitative approaches oriented to soil quality provide more scope for flexibility than quantitative approaches oriented towards land use. In addition, successful implementation of NNLT will depend on engaging with planners and planning practice.

Epidemiology of SLE in Italy: an observational study using a primary care database

ObjectivesTo estimate the incidence and prevalence of SLE in Italy, and to describe the demographic and clinical characteristics of patients with newly diagnosed SLE.MethodsA retrospective cohort study was conducted using...

Environmental regulations and firms’ integration in global markets: using a new environmental performance index

This paper investigates how the environmental performance of firms impacts their participation in global value chains (GVC). The analysis is based on a dataset of 15,922 firms located in 32 European, Central Asian, Middle Eastern, and North African countries, with information on firm-level environmental practices provided by the recent Green Economy module of the World Bank Enterprise Surveys. We propose the Firm Environmental Performance Index (FEPI), a new index measuring firms’ adoption of environmental actions. The index is used in a two-part instrumental variable approach to estimate the impact of FEPI on both the probability and the intensity of GVC participation, while addressing reverse causality concerns. The results indicate that a one-standard deviation increase in the FEPI increases the probability of participation by 6.4 percentage points, a result consistently observed in all regions and sectors. The effects on the intensity of participation are mostly non-significant. However, a negative effect is observed in exceptional cases, namely for firms that are importers only, have low-technology practices, and are located in less developed regions. The results are robust to alternative definitions of GVC participation, inclusion of alternative instruments, and to partial violations of the exclusion restriction. All in all, they suggest that complying with environmental regulations could lead to higher integration in global markets, albeit with adverse effects in some particular cases.

Social diversity and social cohesion in Britain.

We use data from a large-scale and nationally representative survey to examine whether there is in Britain a trade-off between social diversity and social cohesion. Using six separate measures of social cohesion (generalised trust, volunteering, giving to charity, inter-ethnic friendship, and two neighbourhood cohesion scales) and four measures of social diversity (ethnic fractionalisation, religious fractionalisation, percentage Muslim, and percentage foreign-born), we show that, net of individual covariates, there is a negative association between social diversity and most measures of social cohesion. But these associations largely disappear when neighbourhood deprivation is taken into account. These results are robust to alternative definitions of neighbourhood. We also investigate the possibility that the diversity--cohesion trade-off is found in more segregated neighbourhoods. But we find very little evidence to support that claim. Overall, it is material deprivation, not diversity, that undermines social cohesion.

From red tape to innovation: How does municipal government financing reform affect corporate R&amp;D activities?

AbstractWe evaluated the effect of an exogenous shock on municipal government debt financing reform on corporate innovation for a sample of Chinese‐listed firms from 2009 to 2019. The results show that this reform stimulates corporate innovation capacity, and the effect is more pronounced in non‐state‐owned and financially constrained firms. We attribute these findings to reduced external financing costs and the crowding‐out effect of a firm's real estate investment. Our results are robust to alternative variable definitions, model specifications, and estimation techniques and provide novel evidence concerning the role of municipal government financing in corporate innovation.

Shedding light on consumer sentiments: evidence from India

ABSTRACT This paper shows how location-based indicators can predict consumer confidence in India. We capture local economic activity using city-wise night-time luminosity (NTL) data. Using data on unit-level observations on consumer confidence from the Consumer Confidence Survey by the Reserve Bank of India from June 2016 to November 2021, we find that NTL is positively associated with consumer sentiments. Our results are robust to alternative definitions of consumer sentiments. Finally, we extend our study to analyse the role of NTL on several individual components of household sentiments, such as household perception and outlook on household income, spending, employment and general price levels. Overall, our results provide fascinating insights about using NTL as a measure of local economic indicators and its implications on households’ sentiment indicators.

Conceptual Overview of Prevalence of Prediabetes.

Prediabetes increases the risk of type 2 diabetes, metabolic syndrome, chronic renal disease, and cardiovascular disease in a person. In current practice, five alternative definitions of prediabetes are utilized, each based on different HbA1C, fasting glucose, and 2-hour glucose cut points. Prediabetes is a common condition that occurs between normal glycemia and diabetes. It is more common in elderly and obese people. The prevalence of prediabetes and diabetes can be influenced by a variety of individual, family, and societal variables. Additionally, as diabetes is the primary contributor to non-communicable diseases (NCD), it is crucial to identify the key temporal variables for diabetes early diagnosis. In turn, effective prediabetes and diabetes awareness, control, and preventive programs may be created by policymakers and public health professionals worldwide. Popular pathogenic pathways in prediabetes include insulin resistance, inflammation, and sensitivity to insulin. HBA1C, OGTT, and FPG are discussed as the diagnostic criteria in order of frequency. The most commonly researched therapies in the realm of prediabetes are metformin, exercise, and physical activity. Physiological markers including BMI, blood pressure, and waist circumference prompted relatively significant concern. Despite declining trends, the study demonstrates that prediabetes and diabetes are widely prevalent. In order to prevent non-communicable illnesses, the research suggests encouraging healthy lifestyles and regular screenings.

Terminology at the border of linguistics and psychology: to the problem of strict definitions

The article is devoted to an analytical review of ambiguously defined terms and commonly used lexical units related to the mental sphere, which linguists use to some extent. The article reveals in detail the problem of the importance of the strictest possible definitions for such vocabulary when it is used both in linguistic texts and in general in the texts of humanitarian studies. In order to accurately formulate definitions for the twenty lexical units listed in the introduction, the main part of the article provides an independent analysis of basic psychological and semiotic concepts based on current anthropological knowledge. For each of the twenty lexical units, a strict definition is independently formulated. In a number of cases, detailed comments are given on the expected degree of accuracy of the definition, on the shortcomings of possible alternative definitions, on the ambiguity of the lexical unit, etc. In addition to independent definitions of some lexical units, definitions already existing in scientific circulation are given, which are evaluated in the article as successful. At the end of the analytical review, a model of speech communication is formulated in the form of a scheme, based on the conclusions made in the review. The practical orientation of the review is the preparation of a fundamental theoretical basis for a Ph.D. research devoted to the compilation of an original lexical thesaurus for machine sentiment analysis.

Empowering Simple Graph Convolutional Networks.

Many neural networks for graphs are based on the graph convolution (GC) operator, proposed more than a decade ago. Since then, many alternative definitions have been proposed, which tend to add complexity (and nonlinearity) to the model. Recently, however, a simplified GC operator, dubbed simple graph convolution (SGC), which aims to remove nonlinearities was proposed. Motivated by the good results reached by this simpler model, in this article we propose, analyze, and compare simple graph convolution operators of increasing complexity that rely on linear transformations or controlled nonlinearities, and that can be implemented in single-layer graph convolutional networks (GCNs). Their computational expressiveness is characterized as well. We show that the predictive performance of the proposed GC operators is competitive with the ones of other widely adopted models on the considered node classification benchmark datasets.

Euclid preparation

Aims. We derived galaxy colour selections from Euclid and ground-based photometry, aiming to accurately define background galaxy samples in cluster weak-lensing analyses. These selections have been implemented in the Euclid data analysis pipelines for galaxy clusters. Methods. Given any set of photometric bands, we developed a method for the calibration of optimal galaxy colour selections that maximises the selection completeness, given a threshold on purity. Such colour selections are expressed as a function of the lens redshift. Results. We calibrated galaxy selections using simulated ground-based griz and EuclidYEJEHE photometry. Both selections produce a purity higher than 97%. The griz selection completeness ranges from 30% to 84% in the lens redshift range zl ∈ [0.2, 0.8]. With the full grizYEJEHE selection, the completeness improves by up to 25 percentage points, and the zl range extends up to zl = 1.5. The calibrated colour selections are stable to changes in the sample limiting magnitudes and redshift, and the selection based on griz bands provides excellent results on real external datasets. Furthermore, the calibrated selections provide stable results using alternative photometric aperture definitions obtained from different ground-based telescopes. The griz selection is also purer at high redshift and more complete at low redshift compared to colour selections found in the literature. We find excellent agreement in terms of purity and completeness between the analysis of an independent, simulated Euclid galaxy catalogue and our calibration sample, except for galaxies at high redshifts, for which we obtain up to 50 percentage points higher completeness. The combination of colour and photo-z selections applied to simulated Euclid data yields up to 95% completeness, while the purity decreases down to 92% at high zl. We show that the calibrated colour selections provide robust results even when observations from a single band are missing from the ground-based data. Finally, we show that colour selections do not disrupt the shear calibration for stage III surveys. The first Euclid data releases will provide further insights into the impact of background selections on the shear calibration.

Quantifying the Impact of Alternative Definitions of Sepsis-Associated Acute Kidney Injury on its Incidence and Outcomes: A Systematic Review and Meta-Analysis.

To derive a pooled estimate of the incidence and outcomes of sepsis-associated acute kidney injury (SA-AKI) in ICU patients and to explore the impact of differing definitions of SA-AKI on these estimates. Medline, Medline Epub, EMBASE, and Cochrane CENTRAL between 1990 and 2023. Randomized clinical trials and prospective cohort studies of adults admitted to the ICU with either sepsis and/or SA-AKI. Data were extracted in duplicate. Risk of bias was assessed using adapted standard tools. Data were pooled using a random-effects model. Heterogeneity was assessed by using a single covariate logistic regression model. The primary outcome was the proportion of participants in ICU with sepsis who developed AKI. A total of 189 studies met inclusion criteria. One hundred fifty-four reported an incidence of SA-AKI, including 150,978 participants. The pooled proportion of patients who developed SA-AKI across all definitions was 0.40 (95% CI, 0.37-0.42) and 0.52 (95% CI, 0.48-0.56) when only the Risk Injury Failure Loss End-Stage, Acute Kidney Injury Network, and Improving Global Outcomes definitions were used to define SA-AKI. There was significant variation in the incidence of SA-AKI depending on the definition of AKI used and whether AKI defined by urine output criteria was included; the incidence was lowest when receipt of renal replacement therapy was used to define AKI (0.26; 95% CI, 0.24-0.28), and highest when the Acute Kidney Injury Network score was used (0.57; 95% CI, 0.45-0.69; p < 0.01). Sixty-seven studies including 29,455 participants reported at least one SA-AKI outcome. At final follow-up, the proportion of patients with SA-AKI who had died was 0.48 (95% CI, 0.43-0.53), and the proportion of surviving patients who remained on dialysis was 0.10 (95% CI, 0.04-0.17). SA-AKI is common in ICU patients with sepsis and carries a high risk of death and persisting kidney impairment. The incidence and outcomes of SA-AKI vary significantly depending on the definition of AKI used.