Alternative Route Research Articles

Joint approximate diagonalization approach to quasiparticle self-consistent GW calculations.

We introduce an alternative route to quasiparticle self-consistent GW calculations (qsGW) on the basis of a joint approximate diagonalization of the one-body GW Green's functions G(εnQP) taken at the input quasiparticle energies. Such an approach allows working with the full dynamical self-energy, without approximating the latter by a symmetrized static form as in the standard qsGW scheme. Calculations on the GW100 molecular test set lead, nevertheless, to a good agreement, at the 60meV mean-absolute-error accuracy on the ionization potential, with respect to the conventional qsGW approach. We show further that constructing the density matrix from the full Green's function as in the fully self-consistent scGW scheme, and not from the occupied quasiparticle one-body orbitals, allows obtaining a scheme intermediate between the qsGW and scGW approaches, closer to coupled-cluster reference values.

Conventional and antibody-enhanced DENV infection of human macrophages induces differential immunotranscriptomic profiles.

Dengue virus (DENV) is a mosquito-borne flavivirus which coexists as four genetically and immunologically distinct serotypes (DENV-1 to -4). In secondary heterologous DENV infection, pre-existing immunity is believed to contribute to severe disease through antibody-dependent enhancement (ADE). Although the elevated pathology observed in ADE conditions has been described, the cell-intrinsic mechanisms governing this process remain unclear. Using single-cell RNA sequencing (scRNAseq), we investigated the transcriptomic profiles of human monocyte-derived macrophages infected by DENV-2 in ADE compared to conventional infection conditions. Unsupervised analysis of scRNAseq data enabled the identification of two distinct cell populations in a heterogeneous cell culture, likely representing infected and bystander/uninfected cells. Differential gene expression and ingenuity pathway analyses revealed a number of significantly upregulated and downregulated genes and gene networks between cells infected by ADE compared to conventional infection. Specifically, these pathways indicated mechanisms such as suppressed interferon signaling and inflammatory chemokine transcription in cells infected via ADE. Further analysis revealed that transcriptomic changes were independent of viral RNA within infected cells, suggesting that the observed changes are reflective of cell-intrinsic responses and not simply a function of per-cell viral burden. The interpreted "bystander" cell population also demonstrated distinct profiles in ADE conditions, indicating an immunologically activated phenotype enriched for the expression of gene networks involved with protein translation, cytokine production, and antigen presentation. Together, these findings support the concept that DENV infection via ADE induces a qualitatively different transcriptomic response in infected cells, contributing to our understanding of ADE as a mechanistic driver of disease and pathogenesis.IMPORTANCEDengue virus (DENV) is a mosquito-borne human pathogen with a significant and growing global health burden. Although correlates of severe dengue disease are poorly understood, pre-existing immunity to DENV has been associated with severe disease risk and known to contribute to an alternative route of viral entry termed antibody-dependent enhancement (ADE). Using single-cell RNA sequencing, we identified distinct transcriptomic processes involved in antibody-mediated DENV entry compared to conventional receptor-mediated entry. These data provide meaningful insight into the discrete processes contributing to DENV pathogenesis in ADE conditions.

In‐tandem Electrochemical Reduction of Nitrate to Ammonia on Ultrathin‐Sheet‐Assembled Iron–Nickel Alloy Nanoflowers

The development of alternative routes for ammonia (NH3) synthesis with high Faradaic efficiency (FE) is crucial for energy conservation and to achieve zero carbon emissions. Electrocatalytic nitrate (NO3−) reduction to NH3 (e‐NO3RRA) is a promising alternative to the energy‐intensive, fossil‐fuel‐driven Haber–Bosch process. The implementation of this innovative NH3 synthesis technique requires an efficient electrocatalyst and in‐depth mechanistic understanding of e‐NO3RRA. In this study, we developed an ultrathin sheet (µm) iron–nickel nanoflower alloy through electrodeposition and used it for e‐NO3RRA under alkaline conditions. The prepared Fe–Ni alloy exhibited an FE of 97.28 ± 1.36% at −238 mVRHE with an NH3 yield rate of 3999.1 ± 242.59 mg h−1 cm−2. Experimental electrolysis, in‐situ Raman spectroscopy, and density functional theory calculations showed that the adsorption and reduction of NO3− to NO2− occurred on the Fe surface, whereas subsequent hydrogenation of NO2− to NH3 occurred preferentially on the Ni surface. The catalysts exhibited comparable FE for at least 10 cycles, with a long‐term stability of 216 h. Electron paramagnetic resonance results confirmed that adsorbed hydrogen was consumed during e‐NO3RRA. This work introduces a sustainable, robust, and efficient Fe–Ni alloy electrocatalyst, offering an environmentally friendly approach for synthesizing NH3 from NO3−‐contaminated water.

In-tandem Electrochemical Reduction of Nitrate to Ammonia on Ultrathin-Sheet-Assembled Iron-Nickel Alloy Nanoflowers.

The development of alternative routes for ammonia (NH3) synthesis with high Faradaic efficiency (FE) is crucial for energy conservation and to achieve zero carbon emissions. Electrocatalytic nitrate (NO3-) reduction to NH3 (e-NO3RRA) is a promising alternative to the energy-intensive, fossil-fuel-driven Haber-Bosch process. The implementation of this innovative NH3 synthesis technique requires an efficient electrocatalyst and in-depth mechanistic understanding of e-NO3RRA. In this study, we developed an ultrathin sheet (µm) iron-nickel nanoflower alloy through electrodeposition and used it for e-NO3RRA under alkaline conditions. The prepared Fe-Ni alloy exhibited an FE of 97.28 ± 1.36% at -238 mVRHE with an NH3 yield rate of 3999.1 ± 242.59 mg h-1 cm-2. Experimental electrolysis, in-situ Raman spectroscopy, and density functional theory calculations showed that the adsorption and reduction of NO3- to NO2- occurred on the Fe surface, whereas subsequent hydrogenation of NO2- to NH3 occurred preferentially on the Ni surface. The catalysts exhibited comparable FE for at least 10 cycles, with a long-term stability of 216 h. Electron paramagnetic resonance results confirmed that adsorbed hydrogen was consumed during e-NO3RRA. This work introduces a sustainable, robust, and efficient Fe-Ni alloy electrocatalyst, offering an environmentally friendly approach for synthesizing NH3 from NO3--contaminated water.

Capacity Management Strategy for Handling Traffic Load with Dijkstra Algorithm at PT XYZ

In the digital era marked by rapid data growth, network congestion occurs when network capacity cannot handle the transmitted data volume, becoming a significant challenge that impacts the Quality of Service (QoS). This study proposes an effective capacity management strategy, which includes alternative routing, load balancing, and capacity enhancement, involving the optimized Dijkstra Algorithm and a Decision Support System (DSS) to improve QoS. The Dijkstra Algorithm is effective in reducing the load on congested routes and ensuring balanced traffic distribution, which enhances the capacity and reliability of the network. The results indicate a reduction in packet loss from 142.353 to 66.340 packets (or 53,39%) and an increase in the number of packets successfully transmitted from 122.542 to 198.555 packets (or 61,98%). Specific node capacity increases have significantly bolstered data transmission success. This comprehensive strategy not only improves the reliability of data transmission and network performance consistency but also enables the network to adapt to growing demands without degrading performance, confirming the efficacy of capacity management in addressing capacity challenges and improving QoS.

Quest for the optimal venous access in a complex skull base dural fistula: Case illustrations and principles.

Treatment of dural arteriovenous fistulae (DAVFs) is dynamic and evolves between diagnostic and therapeutic angiography.A 79-year-old man with a left jugular foramen DAVF presented with new onset cranial nerve XII palsy. The DAVF progressed from Cognard grade I to IIa + b. A transvenous approach was chosen. Attempts to access the left inferior petrosal sinus (IPS) via the left internal jugular vein failed due to occlusion. An alternative route through the left superior ophthalmic vein and left cavernous sinus to the IPS was devised. Successful coil occlusion of the IPS was achieved. Postoperatively, symptoms resolved, and angiography showed no cortical venous reflux.

A new technique: endoscopic transmass odontoidotomy.

Basilar invagination (BI) represents a complex anomaly of the craniovertebral junction, characterized by the displacement of the odontoid process towards the foramen magnum. Current surgical interventions include anterior decompression and combined anterior-posterior decompression with posterior fusion. Traditional methods for odontoid resection encompass transoral, transnasal, and endonasal approaches. However, these techniques are fraught with significant risks. Furthermore, the restricted exposure provided by the endonasal corridor's anatomical limitations hampers surgical manipulation, prompting spine surgeons to seek alternative techniques. This report details a case of BI managed through an endoscopic posterolateral odontoidotomy, showcasing an innovative surgical approach. We aim to describe our experience in partially removing the odontoid via posterolateral approach with a novel endoscopic technique, preventing the need for additional approach and related complications. A 16-year-old male patient presented with complaints of imbalance and difficulty swallowing. Clinical examination revealed upper extremity muscle weakness, ataxic gait, and dysphagia. Upon the diagnosis of BI, a posterior occipito-cervical fusion was performed. However, six months postoperatively, the patient returned with exacerbated symptoms. During the subsequent surgical intervention, the odontoid body was resected using a posterolateral transmass endoscopic approach. Due to the patient's neck and shoulder anatomy, cranial angulation of the endoscope was restricted, necessitating the retention of the odontoid tip. Post-operative CT revealed that the tip was closer to the base and a subarachnoid space was formed. Follow-up CT after a year showed a complete migration of the tip to the base of C2 with a clear decompression of the brainstem. Our findings demonstrate that partial or total resection of the odontoid process via a posterolateral approach is feasible using endoscopic techniques. The endoscopic posterolateral transmass odontoidotomy should be considered a viable alternative method and route for patients necessitating partial or total odontoidectomy.

On the nonlinear rovibrational excitation of phononic frequency combs in molecules

The mechanical analog of optical frequency combs, phononic frequency combs (PFCs), has recently been demonstrated in mechanical resonators via nonlinear coupling among multiple phonon modes. However, the requisite strong nonlinear couplings need not be readily present for exciting phononic combs in molecules. To overcome this limitation, this paper introduces an alternative route for generating phononic combs in polar molecules. Theoretically, we investigated the radiation and phononic spectra generated from CO molecules possessing relatively large permanent dipole moment with density matrix formalism. By considering the rovibronic excitation of the ground-state CO molecule while avoiding the electronic excitation, the contribution of the permanent dipole moment and electric dipole polarizability to creating PFCs is demonstrated and distinguished. The finding could motivate the possible extension of combs to molecular systems to offer new avenues in molecular sciences.

Comparison of Perioperative Analgesic Efficacy of Lidocaine Intratesticular Block and Spermatic Cord Instillation in Feline Castration

Intratesticular block is an effective local anesthetic technique for castration; however, its use may be limited in cases of testicular masses or infections. Instillation is a simple technique used in several procedures, though studies investigating its application in feline castration remain scarce. Therefore, this study aimed to compare the perioperative analgesic efficacy of lidocaine intratesticular block and spermatic cord instillation in feline castration. Forty-five male cats were randomly divided into three groups: the intratesticular block group (IT), the spermatic cord instillation group (S), and the control group (C). All cats were anesthetized using the same protocol and both techniques were performed based on group assignments. Lidocaine (2 mg/kg) was administrated according to the designated route, while 0.9% normal saline was used for the alternative route and in the C group. Intraoperative parameters were recorded, showing that noninvasive blood pressure in the IT and S groups was significantly lower than in the C group. Although both lidocaine intratesticular block and spermatic cord instillation effectively reduce surgical noxious stimulation, intratesticular block is recommended as it provides more stable intraoperative vital signs and less postoperative pain. Therefore, spermatic cord instillation can be considered as an optional technique for managing pain in feline castration.

Abstract TP149: Development and Implementation of an Algorithm for Early Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement in Acute Stroke Patients

Background: Dysphagia is a common complication of stroke and often leads to the need for modified diets and alternate feeding routes. Length of stay (LOS) for stroke patients requiring percutaneous endoscopic gastrostomy (PEG) tubes is often longer than those who can eat by mouth. The decision to place a PEG is multifactorial and multidisciplinary, involving speech-language pathologist (SLP), dietary, and neurology input, as well as goals of care. Despite this complex decision-making process, there are few existing algorithms to guide the need and timing for PEG placement. Hypothesis: Use of a PEG algorithm will result in timelier PEG placement and shorter LOS for acute stroke patients requiring artificial nutrition. Methods: A multidisciplinary team, including physicians, nurses, registered dieticians, and SLPs designed an evidenced based algorithm to guide PEG placement. Based on assessment and individual patient factors, possible algorithm pathways included dysphagia treatment and/or calorie count by nursing and dieticians to guide decision-making for PEG placement. A retrospective study was conducted in the inpatient setting of a comprehensive stroke center. Data included 68 acute ischemic and hemorrhagic stroke patients admitted to the Neurology and Neurosurgery services from 1/1/2023-2/29/24. Only those patients who were identified as being at risk for significant oropharyngeal dysphagia, aspiration pneumonia, and/or malnutrition were included in the study. Data collected included age, diet recommendation, and initial National Institutes of Health Stroke Scale Score with a focus on length of time from PEG recommendation to PEG placement and LOS. Statistical analysis was completed via t-test. Results: Comparing algorithm (n=30) and non-algorithm (n=38) groups, there was an average decrease of 3.86 days from PEG recommendation to placement in the algorithm group. Although this was not statistically significant (p=0.211), this resulted in decreased LOS from 24.2 to 20.0 days and hospital savings of ~ $7,720 per patient. Conclusions: Implementation of a multidisciplinary PEG algorithm resulted in reduced time from PEG recommendation to placement and shorter LOS. This novel process helped to guide decision-making for timelier PEG placement. Ongoing studies will be powered to assess overall impact on LOS, costs, outcomes, and complications.

Nose-to-brain Drug Delivery System: An Emerging Approach to Chemotherapy-induced Cognitive Impairment.

The rise in global cancer burden, notably breast cancer, emphasizes the need to address chemotherapy-induced cognitive impairment, also known as chemobrain. Although chemotherapy drugs are effective against cancer, they can trigger cognitive deficits. This has triggered the exploration of preventive strategies and novel therapeutic approaches. Nanomedicine is evolving as a promising tool to be used for the mitigation of chemobrain by overcoming the blood-brain barrier (BBB) with innovative drug delivery systems. Polymer and lipid-based nanoparticles enable targeted drug release, enhancing therapeutic effectiveness. Utilizing the intranasal route of administration may facilitate drug delivery to the central nervous system (CNS) by circumventing first-pass metabolism. Therefore, knowledge of nasal anatomy is critical for optimizing drug delivery via various pathways. Despite challenges, nanoformulations exhibit the potential in enhancing brain drug delivery. Continuous research into formulation techniques and chemobrain mechanisms is vital for developing effective treatments. The intranasal administration of nanoformulations holds promise for improving therapeutic outcomes in chemobrain management. This review offers insights into potential future research directions, such as exploring novel drug combinations, investigating alternative delivery routes, or integrating emerging technologies to enhance the efficacy and safety of nanoformulations for chemobrain management.

Targeted metals extraction from spent LiNi0.5Co0.2Mn0.3O2 batteries via thermochemical-induced sulfation roasting: Thermodynamics & kinetics.

To alleviate the energy crisis and control environmental pollution raised by spent lithium-ion batteries (LIBs), the development of efficient and economic methods for their recycling is crucial for sustainable development of new energy industry. Herein, a combined pyro-hydrometallurgical process was adopted for recovery of valuable metal elements for spent LiNi0.5Co0.2Mn0.3O2 (NCM523). Different from conventional pyrometallurgical methods with high temperature and energy consumption, the NH4HSO4 roasting strategy works at 400°C and achieves remarkable leaching efficiencies of Li, Co, Mn, and Ni achieved 97.5%, 91.4%, 91.3%, and 95.50%, respectively. Under the ideal conditions, abundant water-soluble metal-ammine-sulfates and metal-sulfates were revolved from NCM523. The process factors, including sulfation-roasting temperature, reagent mass ratio, roasting time, are intensively studied. Furthermore, a plausible reaction mechanism was deeply investigated with assistance of macro-micro scale, thermodynamic and kinetic analysis. Wherein, the Li of the NCM523 first react sufficiently with NH4HSO4 owing to higher thermodynamic/kinetic motivation at the primary stage during the sulfation-roasting procedure. Subsequently, the transition metal (Ni, Co, and Mn) from the lithium-depleted NCM523 would revolve to corresponding metal-ammine-sulfates or metal sulfates, and their sulfation-roasting kinetics conformed to the unreacted nuclear model. This study proposed an alternative green route of low energy consumption and acid-free procedure for recovering spent NCM batteries, which is conducive to industrial-scale recycling of waste LIBs in the future.

Importance of learning paths’ design in MOOCs: An analysis under the socio-cultural vision of education lens

Massive Open Online Courses (MOOCs) have profoundly influenced online education, offering innovative approaches to learning and teaching that focus on autonomous work and carefully structured curricula. This study examines the relationship between adherence to a proposed learning path in a coding MOOC and students’ performance in the course. A key component of MOOCs is learning processes which are organized activities intended to guide learners. However, the factors determining their success or failure have received little attention. An analytical method was used to collect, clean, analyze, and visualize data from the learning pathways in the course. A subsequent analysis was conducted to interpret the results grounded in the socio-cultural theory of education. The findings indicate that students who adhered to the proposed learning path performed significantly better than those who chose alternative navigation routes. This effectiveness is explained through the socio-cultural concepts of participation and reification which illustrate how the sequence of activities supports an environment conducive to meaningful knowledge construction. These results offer practical implications for the design and implementation of MOOCs, underscoring the importance of creating structured learning paths to enhance student engagement, performance, and overall learning outcomes. This study highlights the pedagogical value of intentional course design in digital education.

Anhydrous Actinide Starting Materials: Synthesis and Structural Characterization of [UCl4(Et2O)2], an Alternative Route to [UO2Cl2(THF)2]2, and Comments on the Synthesis of [ThCl4(dme)2

AbstractA new diethyl ether adduct of uranium tetrachloride, [UCl4(Et2O)2] (1), along with the previously reported mono‐etherate complex [UCl4(Et2O)]n (2), have been synthesized and characterized by powder X‐ray diffraction, elemental analysis, and in the case of 1, single crystal X‐ray diffraction. Additionally, reaction of anhydrous [UO2(OAc)2]n with HCl in Et2O/THF was found to afford the uranyl dichloride complex [UO2Cl2(THF)2]2 (3) in high purity and yield, providing an alternative and convenient entry point into anhydrous uranyl chemistry. Furthermore, comments are provided regarding the literature synthesis of [ThCl4(dme)2] via the reaction of [ThCl4(H2O)4] with Me3SiCl in dme, highlighting important considerations for the compound's preparation in good yield.

Question and answers on long-acting therapy with cabotegravir and rilpivirine in people with HIV.

Modern ART is evolving, allowing the use of new drug formulations and alternative routes of administration to oral therapy. Long-acting (LA) cabotegravir and rilpivirine, the first fully injectable antiretroviral regimen approved for clinical use, is a test case for this new route of administration, and an innovation with implications for the quality of life of people with HIV (PWH). However, its use requires a reorganization of outpatient clinics and outpatient services, and a number of issues remain to be defined regarding the management of PWH on LA drugs, including the correct selection of people who can be treated with LA cabotegravir and rilpivirine. There is also ongoing debate about the best way to monitor both efficacy and tolerability of LA treatment and whether the management of virological failures and blips should be different from that reserved for oral regimens. The present article reviews the data on the use and management of LA cabotegravir and rilpivirine in different settings, with a review of clinical trial data and also the first available real-life experiences. The article focuses on the following: the reasons for the use of LA drugs; the implementation of their use in clinical practice; and the monitoring of treated people over time.

Oral tranexamic acid for immediate use in major trauma: implications for mass casualty events

The early administration of tranexamic acid is recognised as significantly reducing mortality in traumatically injured patients with major haemorrhage, typically given via intravenous or intramuscular routes. In the context of...

Non-enzymatic protein targeting agents as a promising strategy for cancer treatment

Increased research attention has been brought to non-enzymatic protein targeting agents as a new and effective strategy for advancing cancer treatment. To discover this class of new anticancer drugs, two molecular approaches targeting the non-enzymatic activities of proteins have shown promising experimental, preclinical, and clinical results. In the first approach, selective agents known as PROteolysis-TArgeting Chimeras (PROTACs) employ innate endogenous protein degradation machinery in cells to proteolyze the targeted protein. The combination of the highly selective PROTACs and exploitation of cellular protein degradation pathways provides the opportunity to treat diseases that were previously deemed incurable due to lack of enzymatic activities of the targeted proteins. The second approach targets protein-protein interactions (PPIs) as an alternative non-enzymatic route that alters the functional activities of protein complexes and thus significantly influence cancer cell fitness and survival. To efficiently identify potential chemical leads for these approaches, high-throughput screening (HTS) has been extremely valuable due to its ability to quickly screen large libraries of compounds. In this review paper, we will provide an overview of developing anti-cancer agents targeting non-enzymatic activities of proteins and the potential clinical impact of this new class of inhibitors.

Facile, Reversible Hydrogen Activation by Low-Coordinate Magnesium Oxide Complexes.

New approaches to achieve facile and reversible dihydrogen activation are of importance for synthesis, catalysis, and hydrogen storage. Here we show that low-coordinate magnesium oxide complexes [{(RDipnacnac)Mg}2(μ-O)] 1, with RDipnacnac = HC(RCNDip)2, Dip = 2,6-iPr2C6H3, R = Me (1a), Et (1b), iPr (1c), readily react with dihydrogen under mild conditions to afford mixed hydride-hydroxide complexes [{(RDipnacnac)Mg}2(μ-H)(μ-OH)] 4. Dehydrogenation of complexes 4 is strongly dependent on remote ligand substitution and can be achieved by simple vacuum-degassing of 4c (R = iPr) to regain 1c. Donor addition to complexes 4 also releases hydrogen and affords donor adducts of magnesium oxide complexes. Computational studies suggest that the hydrogen activation mechanism involves nucleophilic attack of an oxide lone pair at a weakly bound H2···Mg complex in an SN2-like manner that induces a heterolytic dihydrogen cleavage to yield an MgOH and an MgH unit. Alternative synthetic routes into complex 4b from a magnesium hydride complex have been investigated and the ability of complexes 1 or 4 to act as catalysts for the hydrogenation of 1,1-diphenylethene (DPE) has been tested.

Promoting the Emerging Role of Pulse By-Products as Valuable Sources of Functional Compounds and Novel Food Ingredients

The growth of the human population worldwide has increased food demand, generating the massive production of foods and consequently causing enormous production of waste every year. The indiscriminate exploitation of the already limited natural resources has also generated serious environmental and economic crises. The use, or reuse, of waste or by-products represents a viable solution to constrain the problem by promoting alternative routes of exploitation with multiple food and biotechnological applications. This review focuses on the most recent advances in the valorization of food by-products, with specific reference to legume-derived by-products. The main technological solutions for reintroducing and/or valorizing food waste are reported together with a critical discussion of the main pros and cons of each alternative, supported by practical case studies whenever available. First, the possibility to exploit the by-products as valuable sources of functional compounds is presented by reviewing both conventional and innovative extraction techniques tailored to provide functional extracts with multiple food, pharmaceutical, and biotechnological applications. Second, the possibility to valorize the by-products as novel food ingredients by inclusion in different formulations, either as a whole or as hydrolyzed/fermented derivatives, is also presented and discussed. To the best of our knowledge, several of the technological solutions discussed have found only limited applications for waste or by-products derived from the legume production chain; therefore, great efforts are still required to gain the full advantages of the intrinsic potential of pulse by-products.

Priority ranking of alternative Odesa metro plan variants: using modified morphological analysis method

ABSTRACT One of the promising approaches to structuring complex urban development problems that take into account numerous impact criteria and uncertainties is the modified by the authors morphological analysis method that found its application in complex city planning problems and is considered an important process of converting scientific study into management decisions. Using a system methodology and toolset, we present a morphological model for alternative project configurations of the axial line of the Odesa metro, the construction of which will facilitate the post-war evolution of Odesa to a qualitatively new level of dynamic development. The morphological model is developed and calibrated using an original combination of structural and functional factors, which complexly embrace both the existing urban state and the trends of the city’s further growth demonstrating the possibility of using quantitative indicators in the assessment of impact factors. It allowed us to assess the impact of 10 structural and functional factors and to process over 3,49,000 value configurations to obtain numerical estimates for the comparison of the alternative Odesa metro end station locations. The results highlight the metro line direction to the Fontans’ka road as having a higher priority than the basic variant in the direction of the Lyustdorfs’ka road due to criteria preferences: ‘Favoring the city building potential’ (1,38 versus 0,64), ‘Favoring the recreational development’ (0,97 versus 0,34), ‘Minimization of ecological problems’ (0,69 versus 0,62), and ‘Civil defense’ (1,61 versus 1,03). The placement of the metro line closer to the coastal district favours the investment prospects for construction, forming a system of territories for recreational, wellness and tourist functions, new hubs for relocating business activities from the historical city centre to its southern district, as well as better resilience, which can be effectively used for a wide range of urban planning tasks. HIGHLIGHTS Given the complexity of decision-making in the urban planning field, we present a new methodology for guiding sound urban science: modified morphological analysis. We built morphological models of alternative routes of a proposed new subway line of the Odesa, Ukraine metro, as part of a planned post-war reconstruction. The simulation results showed the expediency of replacing the project route of the southern section of the metro with an alternative one (closer to the coastal strip), demonstrating the power of this method to improve urban planning decision-making.