The problem of the dependence of multiparticle reaction-product formation on the interactionregion size is considered both at cosmic-ray and accelerator energies. In cosmic rays, a comparative analysis of interactions induced by protons and light nuclei was performed on the basis of data obtained by the Stratosphere Collaboration. At accelerator energies, the problem was studied by employing data of the EMU Collaboration. The results revealed a substantial distinction between the production processes in these event groups. An analysis of interactions between light nuclei, (C, O, Ne) + (C/N/O); between intermediate and light nuclei, (Si, S) + (C/N/O); and between heavy nuclei, (Au, Pb) + (Ag/Br), showed that there is a sizable enhancement of fluctuations as the size of the interaction region becomes smaller. A sharp growth of multiplicity and pseudorapidity correlations in the most central interactions, (C, O, Ne) + (C/N/O), is interpreted as a manifestation of internal virtual alpha-particle clustering of light nuclei.