Alpha Particle Beam Research Articles

Optical and THz investigations of mid-IR materials exposed to alpha particle irradiation

The paper is the first comprehensive study on alpha particle irradiation effects on four mid-IR materials: CaF2, BaF2, Al2O3 (sapphire) and ZnSe. The measurements of the optical spectral transmittance, spectral diffuse reflectance, radioluminescent emission, terahertz (THz) spectral response, transmittance, absorbance, refractive index, real and imaginary parts of the dielectric constant and THz imaging are used as complementary investigations to evaluate these effects. The simulations were run to estimate: (i) the penetration depth, (ii) the scattering of alpha particle beam, (iii) the amount of material affected by this interaction, and (iv) the number of vacancies produced by the radiation exposure for each type of material. The simulation results are compared to the off-line measurement outcomes. The delay and spectral composition change of the reflected THz signal highlight the modification induced in the tested materials by the irradiation process.

Undergraduate Research and Training in Ion-Beam Analysis of Environmental Materials

We have an active undergraduate research program at the Union College Ion-Beam Analysis Laboratory (UCIBAL) focused on the study of environmental materials. Accelerator-based ion-beam analysis (IBA) is a powerful tool for the study of environmental pollution because it can provide information on a broad range of elements with high sensitivity and low detection limits, is non-destructive, and requires little or no sample preparation. It also provides excellent training for the next generation of environmental scientists. Beams of protons and alpha particles with energies of a few MeV from the 1.1-MV tandem Pelletron accelerator (NEC Model 3SDH) in the UCIBAL are used to characterize environmental samples using IBA techniques such as proton-induced X-ray emission, Rutherford back-scattering, and proton-induced gamma-ray emission. Recent projects include the characterization of atmospheric aerosols in the Adirondack Mountains of upstate New York, the study of heavy metal pollutants in river sediment, measurements of Pb diffusion in sulfide minerals to help constrain the determination of the age of iron meteorites, and the search for heavy metals and toxins in artificial turf.

Interaction of low and high LET radiation in TK6 cells—mechanistic aspects and significance for radiation protection

Most environmental, occupational and medical exposures to ionising radiation are associated with a simultaneous action of different radiation types. An open question remains whether radiations of different qualities interact with each other to yield effects stronger than expected based on the assumption of additivity. It is possible that DNA damage induced by high linear energy transfer (LET) radiation will lead to an opening of the chromatin structure making the DNA more susceptible to attack by reactive oxygen species (ROS) generated by the low LET radiation. In such case, the effect of mixed beams should be strongly expressed in cells that are sensitive to ROS. The present investigation was carried out to test if cells with an impaired capacity to handle oxidative stress are particularly sensitive to the effect of mixed beams of alpha particles and x-rays. Clonogenic cell survival curves and mutant frequencies were analysed in TK6 wild type (wt) cells and in TK6 cells with a knocked down hMYH glycosylase. The results showed a synergistic effect of mixed beams on clonogenic cell survival of TK6wt but not TK6MYH- cells. The frequencies of mutants showed a high degree of interexperimental variability without any indications for synergistic effects of mixed beams. TK6MYH- cells were generally more tolerant to radiation exposure with respect to clonogenic cell survival but showed a strong increase in mutant frequency. The results demonstrate that exposure of wt cells to a mixed beam of alpha particles and x-rays leads to a detrimental effect which is stronger than expected based on the assumption of additivity. The role of oxidative stress in the reaction of cells to mixed beams remains unclear.

Activation cross sections of longer-lived radionuclides produced in germanium by alpha particle irradiation

The cross sections of alpha particles induced nuclear reactions on natural germanium were investigated by using the standard stacked foil target technique, the activation method and high resolution gamma spectrometry. Targets with thickness of about 1μm were prepared from natural Ge by vacuum evaporation onto 25μm thick polyimide (Kapton) backing foils. Stacks were composed of Kapton-Ge-Ge-Kapton sandwich target foils and additional titanium monitor foils with nominal thickness of 11μm to monitor the beam parameters using the natTi(α,x)51Cr reaction. The irradiations were done with Eα=20.7 and Eα=51.25MeV, Iα=50nA alpha particle beams for about 1h. Direct or cumulative activation cross sections were determined for production of the 72,73,75Se, 71,72,74,76,78As, and 69Ge radionuclides. The obtained experimental cross sections were compared to the results of theoretical calculations taken from the TENDL data library based on the TALYS computer code. A comparison was made with available experimental data measured earlier. Thick target yields were deduced from the experimental cross sections and compared with the data published before.

Production of medical Sc radioisotopes with an alpha particle beam

The internal α-particle beam of the Warsaw Heavy Ion Cyclotron was used to produce research quantities of the medically interesting Sc radioisotopes from natural Ca and K and isotopically enriched 42Ca targets. The targets were made of metallic calcium, calcium carbonate and potassium chloride. New data on the production yields and impurities generated during the target irradiations are presented for the positron emitters 43Sc, 44gSc and 44mSc. The different paths for the production of the long lived 44mSc/44gSc in vivo generator, proposed by the ARRONAX team, using proton and deuteron beams as well as alpha-particle beams are discussed. Due to the larger angular momentum transfer in the formation of the compound nucleus in the case of the alpha particle induced reactions, the isomeric ratio of 44mSc/44gSc at a bombarding energy of 29MeV is five times larger than previously determined for a deuteron beam and twenty times larger than for proton induced reactions on enriched CaCO3 targets. Therefore, formation of this generator via the alpha-particle route seems a very attractive way to form these isotopes. The experimental data presented here are compared with theoretical predictions made using the EMPIRE evaporation code. Reasonable agreement is generally observed.

Comparison of experimental and Monte-Carlo simulation of MeV particle transport through tapered/straight glass capillaries and circular collimators

This study compares the capabilities of three different passive collimation devices to produce micrometer-sized beams for proton and alpha particle beams (1.7MeV and 5.3MeV respectively): classical platinum TEM-like collimators, straight glass capillaries and tapered glass capillaries. In addition, we developed a Monte-Carlo code, based on the Rutherford scattering theory, which simulates particle transportation through collimating devices. The simulation results match the experimental observations of beam transportation through collimators both in air and vacuum. This research shows the focusing effects of tapered capillaries which clearly enable higher transmission flux. Nevertheless, the capillaries alignment with an incident beam is a prerequisite but is tedious, which makes the TEM collimator the easiest way to produce a 50μm microbeam.

Medical Radioisotopes Produced Using the Alpha Particle Beam from the Warsaw Heavy Ion Cyclotron

Beam from the Warsaw Heavy Ion Cyclotron K. Szkliniarz, J. Jastrz¦bski, A. Bilewicz, E. Chajduk, J. Choi«ski, A. Jakubowski, Š. Janiszewska, E. Leszczuk, M. Šyczko, M. Sitarz, A. Stolarz, A. Trzci«ska, B. Wis and W. Zipper Heavy Ion laboratory, University of Warsaw, 02-093 Warszawa, Poland Institute of Physics, Department of Nuclear Physics, University of Silesia, Uniwersytecka 4, 40-007 Katowice, Poland Institute of Nuclear Chemistry and Technology, 03-195 Warszawa, Poland Niewodnicza«ski Institute of Nuclear Physics PAS, 31-342 Krakow, Poland

Effects of Alpha Particle and Proton Beam Irradiation as Putative Cross-Talk between A549 Cancer Cells and the Endothelial Cells in a Co-Culture System.

Background: High-LET ion irradiation is being more and more often used to control tumors in patients. Given that tumors are now considered as complex organs composed of multiple cell types that can influence radiosensitivity, we investigated the effects of proton and alpha particle irradiation on the possible radioprotective cross-talk between cancer and endothelial cells. Materials and Methods: We designed new irradiation chambers that allow co-culture study of cells irradiated with a particle beam. A549 lung carcinoma cells and endothelial cells (EC) were exposed to 1.5 Gy of proton beam or 1 and 2 Gy of alpha particles. Cell responses were studied by clonogenic assays and cell cycle was analyzed by flow cytometry. Gene expression studies were performed using Taqman low density array and by RT-qPCR. Results: A549 cells and EC displayed similar survival fraction and they had similar cell cycle distribution when irradiated alone or in co-culture. Both types of irradiation induced the overexpression of genes involved in cell growth, inflammation and angiogenesis. Conclusions: We set up new irradiation chamber in which two cell types were irradiated together with a particle beam. We could not show that tumor cells and endothelial cells were able to protect each other from particle irradiation. Gene expression changes were observed after particle irradiation that could suggest a possible radioprotective inter-cellular communication between the two cell types but further investigations are needed to confirm these results.

Measurement of fresnel diffraction of 29 mev alpha particles on 24Mg, 25Mg, 59Co, 197Au, 209Bi nuclei

The angular distributions of the differential cross sections of elastic cattering of alpha par-ticles on 24Mg, 25Mg, 59Co, 197Au, 209Bi at 29 MeV, obtained on the beam of alpha particles ejected from isochronous cyclotron U-150m with regulated ion energy, were measured. The geometry of the scattering chamber is described and the optimal parameters of the spectrometric system giving best angular resolu-tion of the experimental setup were obtained. The parameters of nuclear targets on which the experiments were made are presented. The areas of Rutherford scattering, Fresnel and Fraunhofer diffraction were de-termined in a wide mass range of incident particles and target nuclei for the ion beam energy 29 MeV, the results which are presented in the form of the "diffraction diagram". The experimental data are described in the framework of the parameterized phase analysis and its analytic version taking into account higher approximations of the parameter of nucleus non-sphericity.

A route for polonium 210 production from alpha-particle irradiated bismuth-209 target

Abstract A method is proposed for production of polonium-210 via the 209Bi(α, 3n)210At nuclear reaction. Bombardment of a bismuth-209 target was performed with a 37 MeV alpha-particle beam that leads to the production of astatine-210 (T 1/2 = 8.1 h), which decays to polonium-210. It is purified from the bismuth target matrix by employing liquid–liquid extraction using tributyl phosphate (TBP) in para-xylene from 7 M hydrochloric acid. Back extraction of polonium-210 was performed by 9 M nitric acid. This method allows to purify a tracer amount of Po-210 (2.6 · 10 –13 mol) from macroscopic amount of Bi (2.8 · 10 –2 mol).

INSTABILITIES DRIVEN BY THE DRIFT AND TEMPERATURE ANISOTROPY OF ALPHA PARTICLES IN THE SOLAR WIND

We investigate the conditions under which parallel-propagating Alfv\'en/ion-cyclotron (A/IC) waves and fast-magnetosonic/whistler (FM/W) waves are driven unstable by the differential flow and temperature anisotropy of alpha particles in the solar wind. We focus on the limit in which $w_{\parallel \alpha} \gtrsim 0.25 v_{\mathrm A}$, where $w_{\parallel \alpha} $ is the parallel alpha-particle thermal speed and $v_{\mathrm A}$ is the Alfv\'en speed. We derive analytic expressions for the instability thresholds of these waves, which show, e.g., how the minimum unstable alpha-particle beam speed depends upon $w_{\parallel \alpha}/v_{\mathrm A}$, the degree of alpha-particle temperature anisotropy, and the alpha-to-proton temperature ratio. We validate our analytical results using numerical solutions to the full hot-plasma dispersion relation. Consistent with previous work, we find that temperature anisotropy allows A/IC waves and FM/W waves to become unstable at significantly lower values of the alpha-particle beam speed $U_\alpha$ than in the isotropic-temperature case. Likewise, differential flow lowers the minimum temperature anisotropy needed to excite A/IC or FM/W waves relative to the case in which $U_\alpha =0$. We discuss the relevance of our results to alpha particles in the solar wind near 1 AU.

Investigation of elemental distribution in cat femoral head by nuclear microprobe and SEM for Paget disease of bone studies

Paget Disease of Bone is a disorder characterized by abnormal bone remodeling, associated with morphological and functional abnormalities of osteoclasts although its etiology remains unproven. Ion beam analysis (IBA) techniques may be useful to characterize the abnormal distribution and concentration of the major and trace elements that can be associated topagetic bone condition. In order to access the viability of this approach, healthy femoral head of cat has been investigated by Particle Induced X-Ray Emission (PIXE),Rutherford Backscattering Spectrometry (RBS) and Scanning Electron Microscopy (SEM).The bone section was irradiated, under vacuum conditions, with a 2.0 MeV alpha particle beam produced by the 2.5 MV Van de Graaff Accelerator of CTN/IST (Lisbon, Portugal). An Oxford Microbeams-type nuclear microprobe was used (OM150 triplet system), which allowed the proton beam to be focused on the bone section with a spatial resolution of 3x4 µm2 and a mean beam current of ~90pA. The X-rays generated by the bone were recorded using an 80 mm2 Link X-ray detector (with a 145 eV energy resolution), that is positioned at 135º to the beam direction. The backscattered particles were collected by a 200 mm2 silicon surface barrier radiation detector with a 15 keV energy resolution that is positioned at 40º to the beam direction in a cornell geometry. SEM observations have been carried out with backscattered electrons (BSE) using a JEOL JSM 7001F microscope equipped with an INCA Oxford Instruments EDS spectrometer for point analyses and X-ray mapping. Standard petrographic procedures have been employed to prepare the samples for SEM observation: the specimens were partly encapsulated in epoxy resin, ground with 800 and 1000-grit SiC paper, polished with 6 μm and 1 μm diamond suspensions and coated with carbon.A selected area of the sample has been scanned with the proton beam, allowing to generateelemental distribution maps for Ca and P (Figure 1). From X-line scans it was possible to extractline profiles of these elements. RBS and PIXE were used to determine the matrix and trace element composition in order to normalize the elemental concentrations. The results are shown in Table 1.Structural information on the Haversian Systems, includingbone lacunaeandosteocytes localization have been obtained by SEM (Figure 2).The combination of these techniques proved to be a viable approach for the Pagetic bone characterization and will be used to analyze the structure of trabecular and cortical bones as well as the distribution and morphology of the pagetic bone cells, which can contribute to clarify the differences between pagetic and healthy bone.V. Corregidor acknowledges the support from FCT-Ciência program. The work was also supported by FCT PEST-OE/CTM-UI0084/2011 grant.

A PARALLEL-PROPAGATING ALFVÉNIC ION-BEAM INSTABILITY IN THE HIGH-BETA SOLAR WIND

We investigate the conditions under which parallel-propagating Alfv\'en/ion-cyclotron waves are driven unstable by an isotropic ($T_{\perp \alpha} = T_{\parallel\alpha}$) population of alpha particles drifting parallel to the magnetic field at an average speed $U_{\alpha}$ with respect to the protons. We derive an approximate analytic condition for the minimum value of $U_{\alpha}$ needed to excite this instability and refine this result using numerical solutions to the hot-plasma dispersion relation. When the alpha-particle number density is $\simeq 5%$ of the proton number density and the two species have similar thermal speeds, the instability requires that $\beta_{\rm p} \gtrsim 1$, where $\beta_{\rm p}$ is the ratio of the proton pressure to the magnetic pressure. For $1\lesssim \beta_{\mathrm p}\lesssim 12$, the minimum $U_{\alpha}$ needed to excite this instability ranges from $0.7v_{\mathrm A}$ to $0.9v_{\mathrm A}$, where $v_{\mathrm A}$ is the Alfv\'en speed. This threshold is smaller than the threshold of $\simeq 1.2v_{\mathrm A}$ for the parallel magnetosonic instability, which was previously thought to have the lowest threshold of the alpha-particle beam instabilities at $\beta_{\mathrm p}\gtrsim 0.5$. We discuss the role of the parallel Alfv\'enic drift instability for the evolution of the alpha-particle drift speed in the solar wind. We also analyze measurements from the \emph{Wind} spacecraft's Faraday cups and show that the $U_{\alpha}$ values measured in solar-wind streams with $T_{\perp \alpha}\approx T_{\parallel\alpha}$ are approximately bounded from above by the threshold of the parallel Alfv\'enic instability.

First online production of radioactive ion beams at VECC

Radioactive ion beams (RIB) have been recently accelerated for the first time at the VECC-RIB facility. Beams of 14O (71s), 42K (12.4h), 43K (22h) and 41Ar (1.8h) have been produced by bombarding 1atm nitrogen and argon gas targets with 1 micro-ampere proton and alpha particle beams from the K130 cyclotron. Radioactive atoms were transported 15m away to the ECR ion-source using a gas-jet transport system. Typical measured intensity of RIB at the separator focal plane is few times 103pps. About 3300pps of 1.4MeV 14O was measured after acceleration through a 3.4m long RFQ linac. The details of the gas-jet coupled ECR and RIB production experiments are presented.

Complex aberrations in lymphocytes exposed to mixed beams of 241Am alpha particles and X-rays

Modern radiotherapy treatment modalities are associated with undesired out-of-field exposure to complex mixed beams of high and low energy transfer (LET) radiation that can give rise to secondary cancers. The biological effectiveness of mixed beams is not known. The aim of the investigation was the analysis of chromosomal damage in human peripheral blood lymphocytes (PBL) exposed to a mixed beam of X-rays and alpha particles. Using a dedicated exposure facility PBL were exposed to increasing doses of alpha particles (from 241Am), X-rays and a mixture of both. Chromosomal aberrations were analysed in chromosomes 2, 8 and 14 using fluorescence in situ hybridisation. The found and expected frequencies of simple and complex aberrations were compared. Simple aberrations showed linear dose–response relationships with doses. A higher than expected frequency of simple aberrations was only observed after the highest mixed beam dose. A linear-quadratic dose response curve for complex aberrations was observed after mixed-beam exposure. Higher than expected frequencies of complex aberrations were observed for the two highest doses. Both the linear-quadratic dose–response relationship and the calculation of expected frequencies show that exposure of PBL to mixed beams of high and low LET radiation leads to a higher than expected frequency of complex-type aberrations. Because chromosomal changes are associated with cancer induction this result may imply that the cancer risk of exposure to mixed beams in radiation oncology may be higher than expected based on the additive action of the individual dose components.

The local skin dose conversion coefficients of electrons, protons and alpha particles calculated using the Geant4 code

The skin tissue-equivalent slab reported in the International Commission on Radiological Protection (ICRP) Publication 116 to calculate the localised skin dose conversion coefficients (LSDCCs) was adopted into the Monte Carlo transport code Geant4. The Geant4 code was then utilised for computation of LSDCCs due to a circular parallel beam of monoenergetic electrons, protons and alpha particles <10 MeV. The computed LSDCCs for both electrons and alpha particles are found to be in good agreement with the results using the MCNPX code of ICRP 116 data. The present work thus validates the LSDCC values for both electrons and alpha particles using the Geant4 code.

A gas-jet transport and catcher technique for on-line production of radioactive ion beams using an electron cyclotron resonance ion-source

Radioactive ion beams (RIB) have been produced on-line, using a gas-jet recoil transport coupled Electron Cyclotron Resonance (ECR) ion-source at the VECC-RIB facility. Radioactive atoms∕molecules carried through the gas-jet were stopped in a catcher placed inside the ECR plasma chamber. A skimmer has been used to remove bulk of the carrier gas at the ECR entrance. The diffusion of atoms∕molecules through the catcher has been verified off-line using stable isotopes and on-line through transmission of radioactive reaction products. Beams of (14)O (71 s), (42)K (12.4 h), (43)K (22.2 h), and (41)Ar (1.8 h) have been produced by bombarding nitrogen and argon gas targets with proton and alpha particle beams from the K130 cyclotron at VECC. Typical measured intensity of RIB at the separator focal plane is found to be a few times 10(3) particles per second (pps). About 3.2 × 10(3) pps of 1.4 MeV (14)O RIB has been measured after acceleration through a radiofrequency quadrupole linac. The details of the gas-jet coupled ECR ion-source and RIB production experiments are presented along with the plans for the future.

Whole cell structural imaging at 20 nanometre resolutions using MeV ions

MeV proton and alpha (helium ion) particle beams can now be focused to 20nm spot sizes, and ion/matter simulations using the DEEP computer code show that these resolutions are maintained through the top micrometre or so of organic material. In addition, the energy deposition profiles of the transmitted ions are laterally constrained to a few nanometers from the initial ion path. This paves the way for high resolution structural imaging of relatively thick biological material, e.g. biological cells. Examples are shown of high resolution structural imaging of whole biological cells (MRC5) using on-axis scanning transmission ion microscopy (STIM). Nanoparticles have the ability to cross the cell membrane, and may therefore prove useful as drug delivery probes. We show that the combination of on-axis STIM for imaging the cell interior, and off-axis STIM for imaging gold nanoparticles with enhanced contrast within the cell, represents a powerful set of ion beam techniques for tracking gold nanoparticles in biological cells. Whole cell imaging at high spatial resolutions represents a new area for nuclear microprobes.

Simulation of radiation effects in ultra-thin insulating layers

The Monte Carlo simulations of charged particle transport are used to investigate the effects of exposing ultra-thin layers of insulators (commonly used in integrated circuits) to beams of protons, alpha particles and heavy ions. Materials considered include silicon dioxide, aluminum nitride, alumina, and polycarbonate - lexan. The parameters that have been varied in simulations include the energy of incident charged particles and insulating layer thickness. Materials are compared according to both ionizing and non-ionizing effects produced by the passage of radiation.

Adsorption and diffusion of strontium in simulated rock fractures quantified via ion beam analysis

AbstractAn experimental technique has been developed and applied to the problem of determining effective diffusion coefficients and partition coefficients of Sr in low permeability geological materials. This technique, the micro-reactor simulated channel method (MRSC), allows rapid determination of contaminant transport parameters with resulting values comparable to those determined by more traditional methods and also creates product surfaces that are amenable for direct chemical analysis. An attempt to further constrain mass flux was completed by detailed ion beam analysis of polished tuff surfaces (tuff is a polycrystalline polyminerallic aggregate dominated by silicate phases) that had been reacted with Sr solutions at concentrations of 10−5, 10−3 and 10−1 mol l−1. Ion beam analysis was carried out using beams of both protons (using particle induced X-ray emission and elastic backscattering spectrometry or EBS) and alpha-particles (using Rutherford backscattering spectrometry). The ion beam analyses showed that increased solution concentrations resulted in increased surface concentrations and that in the highest concentration experiment, Sr penetrated to at least 4 μm below the primary interface. The Sr surface concentrations determined by EBS were 0.06 (±0.05), 0.87 (±0.30) and 2.40 (±1.0) atomic weight % in the experiments with starting solution concentrations of 10−5, 10−3, and 10−1 mol l−1, respectively.