Alloys For Biomedical Applications Research Articles

Effect of Heat Treatment on Microstructure, Mechanical and Corrosion Behavior of Ti-7Mo-8Nb Alloy for Biomedical Applications

Effect of Heat Treatment on Microstructure, Mechanical and Corrosion Behavior of Ti-7Mo-8Nb Alloy for Biomedical Applications

Nanopowder-mixed EDM on biodegradable Mg alloy AZ31B for improved surface characteristics and biocompatibility

Powder-mixed electrical discharge machining (PM-EDM) was conducted on biodegradable magnesium (Mg) alloys for biomedical applications. The Mg alloy AZ31B has shown outstanding mechanical properties, similar to human bone, and is lightweight. Efforts were made to enhance the EDM capabilities by a PM-EDM process using nanopowder mixed in the dielectric medium and copper tool electrode amid the machining of Mg alloy AZ31B, followed by investigating surface modification by minimum machining time, morphology, chemistry, topography and wettability of the surfaces. The surface produced by nano PM-EDM operation exhibits minimal cracks and craters, an acceptable range of recast layer thickness (2.4 − 2.7μm), satisfactory corrosion resistance and surface roughness (Ra = 2.87μm) as well as suitable hydrophobic behaviour (CA122q) and bioactivity with Ringer’s solution, suggesting an improvement in the degradation rate. Thus, PM-EDM-induced surface modification suggests the suitability of Mg alloy AZ31B as a biodegradable implant in adults and children.

Tribological properties of MAO ceramic coatings with annulus array texture on disposable surgical gloves.

Introduction: In recent research, the expansion in the use of Mg alloys for biomedical applications has been approached by modifying their surfaces in conjunction with micro-arc oxidation (MAO) techniques which enhance their abrasion and corrosion resistance. Methods: In this study, combining laser texturing and MAO techniques to produce the dense ceramic coatings with microstructures. On the surface of the AZ31 Mg alloy, a micro-raised annulus array texture has been designed in order to increase the surface friction under liquid lubrication and to improve the operator's grip when holding the tool. For this work, the micro-morphology of the coatings was characterised, and the friction properties of the commonly used scalpel shank material 316L, the untextured surface and the textured surface were comparatively analysed against disposable surgical gloves. Results and discussion: The results show that the Laser-MAO ceramic coating grows homogenous, the porosity decreases from 14.3% to 7.8%, and the morphology after friction indicates that the coating has good wear resistance. More specifically, the average coefficient of friction (COF) of the three types of gloves coated with Laser-MAO ceramic was higher than that of the 316L and MAO ceramic coatings under the action of the annulus-integrated texture under the lubrication conditions of physiological saline and defatted sheep blood, which achieved the goal of increasing friction for the purpose of helping to prevent the problem of tool slippage from the hand.

Multifunctional Coatings on Mg‐Based Metallic Biomaterials and Implants

Multifunctional materials are propitious materials with numerous functionalities that make them an ideal option for implants and biomedical applications that should simultaneously fulfill various requirements, including satisfactory mechanical strength, biocompatibility, antibacterial property, hydrophilicity, etc. Magnesium, as a metallic biomaterial, fulfills the required mechanical properties, but unfortunately, in some ways alone, it cannot provide the required biological properties. For instance, magnesium alloys suffer from poor corrosion resistance and high biodegradability, which should be carefully controlled. On the other hand, multifunctional materials alone are not able to provide the required properties in biomedical applications because the vast majority of them do not have the necessary strength and stability. Therefore, the use of magnesium together with multifunctional or composite coatings will be a very advantageous choice for meeting the needs of implants and biomedical materials. The current study focuses on the introduction and utilization of various multifunctional coatings and composites on Mg‐based alloys for biomedical applications. Numerous organic and inorganic materials could be utilized as composites or multifunctional materials. In this regard, numerous types of coating and composite materials, their production technologies, mechanisms, resultant properties, and the involved parameters are thoroughly discussed to provide a comprehensive guide for those interested in this field.

Experimental Investigation of the Impact of Niobium Additions on the Structural Characteristics and Properties of Ti-5Cr-xNb Alloys for Biomedical Applications.

In this study, a series of Ti-5Cr-xNb alloys with varying Nb content (ranging from 1 to 40 wt.%) were investigated to assess their suitability as implant materials. Comprehensive analyses were conducted, including phase analysis, microscopy examination, mechanical testing, and corrosion resistance evaluation. The results revealed significant structural alterations attributed to Nb addition, notably suppressing the formation of the ω phase and transitioning from α' + β + ω to single β phase structures. Moreover, the incorporation of Nb markedly improved the alloys' plastic deformation ability and reduced their elastic modulus. In particular, the Ti-5Cr-25Nb alloy demonstrated high values in corrosion potential and polarization resistance, signifying exceptional corrosion resistance. This alloy also displayed high bending strength (approximately 1500 MPa), a low elastic modulus (approximately 80 GPa), and outstanding elastic recovery and plastic deformation capabilities. These aggregate outcomes indicate the promising potential of the β-phase Ti-5Cr-25Nb alloy for applications in orthopedic and dental implants.

Laser texturing and oxidation of TiZrTa thin films to improve the biocompatible performance of titanium alloys

Titanium (Ti) and Ti alloys possess extensive applications in the medical field due to their non-toxic, biocompatible, and antibacterial properties. This study investigates the biocompatibility enhancement of a Ti-based alloy, Ti-6Al-4V, through a multi-step process involving cathodic arc ion plating of a TiZrTa thin film and subsequent laser-textured oxidation (LTO). LTO treatment produced a structured microtopography with regular groove patterns, including straight lines (L-s), circles (L-c), and checkboards (L-ch), resulting in surface oxidation and the formation of various oxides on the TiZrTa coating. Microstructure analyses revealed substantial alterations in surface topography induced by laser texturing. Antibacterial assessments against Staphylococcus aureus (S. aureus) showed that the films with LTO treatment did not exhibit significant advantages after 12 or 24 h of coculture because the laser-textured portions consisted of a combination of the film and the substrate, and the antibacterial effect was not obvious. Coatings with LTO treatment significantly improved L-929 mouse fibroblasts cell viability at 48 h, particularly for samples with a 50 μm spacing of straight and circular patterns (L-s and L-c). After two weeks of MG-63 human osteosarcoma cell culture, the viability of all samples reached similar levels. It suggested that the TiZrTa-coated Ti-6Al-4V exhibited good biocompatibility with both cells. This study contributed to the understanding of surface modification techniques for enhancing the biocompatibility of Ti-based alloys in biomedical applications.

Heat treatment protocol for additively manufactured nitinol shape memory alloys in biomedical applications

Additive manufacturing (AM) is getting significant attention in realizing customizable nitinol (NiTi) devices for biomedical applications. However, due to the change in composition and constituent phases occurring during printing and the microstructural inhomogeneity in the printed parts, obtaining a desired set of phase transformation behaviors and superelastic properties is a major challenge. In this work, laser powder bed fusion (LPBF) was used to fabricate NiTi at a very low laser energy density (35 J/mm3) on a titanium base plate while keeping these behaviors and properties within desirable ranges without any structural defects such as crack and delamination. Our measurements showed that the as-printed NiTi exhibited distinct one-step phase transformation with the austenite finish (Af) temperature of 2.1 °C. To increase the Af temperature to 30.2 °C (within the recommended range of Af temperature for biomedical applications), a heat treatment protocol was developed, which includes a solution cycle (at 900 °C for 1 h) followed by an aging cycle (at 450 °C for 30 min). The heat treatment protocol enabled us to attain the homogenized microstructure while creating ultrafine metastable Ni-rich precipitate, Ni4Ti3, which facilitated the desirable phase transformation behavior with the increased Af temperature. The heat-treated sample showed narrower and sharper two-step martensitic phase transformation with the formation of intermediate R-phase. The presence of both Ni4Ti3 and the R-phase was confirmed by the transmission electron microscopic (TEM) analysis. In the superelasticity test at the body temperature, these samples, starting from the 2nd cycle, demonstrated a recovery ratio of more than 90% and a recoverable strain of more than 6.5%. After 10th cycles, the stable recoverable strain was 6.52% with a recovery ratio of 96%, which is the highest superelasticity reported for the LPBF processed NiTi to the best of our knowledge. After the initial deformation process, we expect these NiTi samples to attain near full superelasticity during service. The micro-hardness study also showed that the hardness of the heat-treated samples is less affected by the cyclic loading. Therefore, this paper presents a viable heat treatment protocol, which provides an important processing roadmap in making NiTi implants by AM while maintaining excellent functional properties of NiTi for biomedical applications.

Development of an equiatomic octonary TiNbTaZrMoHfWCr super-high-entropy alloy for biomedical applications

A super-high-entropy alloy (SHEA) with ΔSmix ≥ 2.0R (where R is the gas constant) was designed to produce metallic materials with superior mechanical properties to conventional alloys. As an alternative to conventional quinary high-entropy alloys (HEAs), herein, octonary SHEAs for biomedical applications (BioSHEAs) are proposed for the first time, and the TiNbTaZrMoHfWCr BioSHEA was fabricated. Arc-melted BioSHEA exhibited an extremely high yield strength of 1953 ± 84 MPa, which was approximately 550 MPa higher than that of the quinary TiNbTaZrMo BioHEA. This yield strength is considerably higher than that estimated by the rule of mixtures for pure metals, confirming the achievement of significant solid-solution strengthening induced by a supermulticomponent solid solution composed of elements with different atomic radii. Its biocompatibility was comparable to that of pure Ti and the quinary BioHEA, and superior to that of SUS316L. This study demonstrates the validity of a novel entropy-based guideline for increasing the mixing entropy to achieve metallic materials with ultrahigh strength.

Improved Corrosion Properties of Mg-Gd-Zn-Zr Alloy by Micro-Arc Oxidation

In order to improve the corrosion resistance of Mg-3Gd-1Zn-0.4Zr (GZ31K) alloys for biomedical application, the alloy was micro-arc oxidation (MAO)-treated using silicate electrolyte system under various voltages (400 V, 425 V, 450 V, 475 V). The effects of voltage on the microstructure and corrosion properties of MAO coating were investigated via X-ray diffraction (XRD) and a scanning electron microscope (SEM) combined with an energy-dispersive spectrometer (EDS), X-ray photoelectron spectroscope (XPS), and electrochemical experiments. The results showed that, with the increase in voltage, the MAO coatings became thicker and the micropores on the MAO coating increased in diameter. The main phase compositions of the MAO coatings were MgO and Mg2SiO4. Potentiodynamic polarization curve results showed that MAO coatings could enhance corrosion resistances, where the corrosion current density decreased by six orders of magnitude and the corrosion potential of the specimens increased by 300 mV for the voltage of 450 V in the MAO treatment; nevertheless, the corrosion resistance rapidly deteriorated due to the creation of large micropores in the MAO coating, which provide a pathway for corrosive media when the voltage is 475 V. The electrochemical impedance spectroscopy results showed that MAO treatments could increase low-frequency modulus resistance and increase the corrosion resistance of Mg alloys. In addition, MAO-treated GZ31K alloys still exhibited uniform corrosion, which is desirable for biomedical applications.

Surface electropulsing-induced texture evolution in electron beam melted Ti-6Al-4V alloy for biomedical application

Surface electropulsing treatment has been demonstrated to significantly improve the surface strength of electron beam melted (EBM) Ti-6Al-4V alloy. However, further investigation is needed to understand the effect of this treatment on the surface texture of the alloy, as the texture of Ti alloy plays a crucial role in its corrosion performance. In this study, we explored the changes in texture induced by surface electropulsing in EBM Ti-6Al-4V alloy using electron backscattered diffraction (EBSD) and micro-region X-ray diffraction (Micro-XRD). The results revealed that surface electropulsing created a 〈0001〉α′//transverse direction (TD) texture on the alloy surface, and the intensity of this texture remained unaffected with varying electropulsing time (180–240 ms). Additionally, this treatment led to the formation of long curved martensite laths that could cross the small angle prior-β grain boundaries. The finite element method (FEM) was employed to aid in the analysis of the texture evolution mechanism. The results revealed that the most rapid cooling rate occurred perpendicular to the contact surface with the copper electrode, along the building direction (BD). When the (0001) plane aligned parallel to the direction of the fastest cooling rate, it promoted the growth of martensite, leading to an increased production of martensite with the (0001) plane parallel to the BD direction and generating the 〈0001〉α′//TD texture. Therefore, by controlling the position of the copper electrode during surface electropulsing treatment, it is possible to manipulate the orientation of the (0001) plane of most α′ laths. This suggests that surface electropulsing treatment holds potential for application in other Ti alloys to enhance strength and optimize texture for biomedical applications.

Diopside/graphene-oxide nanocomposite coatings on AZ31 Mg alloy for biomedical applications: Surface characteristics, corrosion, and biocompatibility properties

Surface functionalization of magnesium (Mg)-based alloys with coatings, represents a promising approach to improve the biocompatibility and corrosion resistance of these biodegradable materials for bone tissue engineering. In this study, electrophoretic deposition (EPD) was employed to apply diopside-graphene oxide (Dio/xGO) coatings at different GO concentrations (x= 0, 0.03, 0.06, and 0.12 g/L) onto AZ31 alloy. The study aimed to compare the surface characteristics, corrosion resistance, bioactivity, antibacterial property, and cytocompatibility of these coatings with the uncoated substrate. Diopside (CaMgSi2O6) powder was synthesized using the sol-gel method. FESEM imaging revealed that Dio/0.06GO nanocomposite coating exhibited a more compact morphology compared to the other ones. AFM studies indicated an increase in surface roughness with higher GO concentration, with a Sa=293.80 ± 23.75 nm measured in the Dio/0.12GO sample. A similar trend was observed in the coatings' wettability. The Dio/0.06GO coating exhibited the highest corrosion resistance, with a corrosion current density (icorr) 91.5% lower than the uncoated Mg alloy. Furthermore, apatite deposits with the highest Ca/P atomic ratio (1.61) formed on this coating after seven days of immersion in simulated body fluid (SBF), indicating its superior bioactivity compared to the other ones. Results from the antibacterial activity test showed that GO, particularly at higher concentrations, exhibited bactericidal effect against E. coli and S. aureus. In vitro cellular studies indicated that although Dio/0.12GO coating displayed the most favorable MCT3T-E1 osteoblast cellular adhesion, the highest cell viability (92.17 ± 1.2%) was associated with the Dio/0.6GO deposits. In conclusion, Dio/GO nanocomposite coatings showed the potential to improve corrosion resistance and biological properties in Mg alloy orthopedic applications.

Effect of medium renewal mode on the degradation behavior of Mg alloys for biomedical applications during the long-term in vitro test

To build a suitable corrosion environment for testing the degradation behavior of magnesium alloy in vitro, the medium and test environment are constantly optimized. However, the applicability of medium renewal mode is still vague. In this study, based on three representative test protocols, the influence of the specific ratio of media volume to surface area and the disposable medium real-time renewal mode (flow-through) on Mg corrosion were investigated. It is found that in flow-through medium renewal mode, the composition of the medium is maintained quasi-constant which is essential for corrosion tests. The selection suggestion on medium renewal mode was also proposed. This work is beneficial for ultimately establishing the representative in vitro testing protocols for Mg bioabsorbable materials.

Characterization of Tannic Acid-Coated AZ31 Mg Alloy for Biomedical Application and Comparison with AZ91.

Magnesium alloys are promising materials for bioresorbable implants that will improve patient life and reduce healthcare costs. However, their clinical use is prevented by the rapid degradation and corrosion of magnesium, which leads to a fast loss of mechanical strength and the formation of by-products that can trigger tissue inflammation. Here, a tannic acid coating is proposed to control the degradation of AZ31 and AZ91 alloys, starting from a previous study by the authors on AZ91. The coatings on the two materials were characterized both by the chemical (EDS, FTIR, XPS) and the morphological (SEM, confocal profilometry) point of view. Static degradation tests in PBS and electrochemical measurements in different solutions showed that the protective performances of the tannic acid coatings are strongly affected by the presence of cracks. The presence of fractures in the protective layer generates galvanic couples between the coating scales and the metal, worsening the corrosion resistance. Although degradation control was not achieved, useful insights on the degradation mechanisms of coated Mg surfaces were obtained, as well as key points for future studies: it resulted that the absence of cracks in protective coatings is of uttermost importance for novel biodegradable implants with proper degradation kinetics.

Investigation of the Chemical Composition, Microstructure, Density, Microhardness, and Elastic Modulus of the New β Ti-50Nb-xMo Alloys for Biomedical Applications.

β-type titanium alloys with a body-centered cubic structure are highly useful in orthopedics due to their low elastic modulus, lower than other commonly used alloys such as stainless steel and Co-Cr alloys. The formation of the β phase in titanium alloys is achieved through β-stabilizing elements such as Nb, Mo, and Ta. To produce new β alloys with a low modulus of elasticity, this work aimed to produce our alloy system for biomedical applications (Ti-50Nb-Mo). The alloys were produced by arc-melting and have the following compositions Ti-50Nb-xMo (x = 0, 3, 5, 7, and 12 wt% Mo). The alloys were characterized by density, X-ray diffraction, scanning electron microscopy, microhardness, and elastic modulus. It is worth highlighting that this new set of alloys of the Ti-50Nb-Mo system produced in this study is unprecedented; due to this, there needs to be a report in the literature on the production and structural characterization, hardness, and elastic modulus analyses. The microstructure of the alloys has an exclusively β phase (with bcc crystalline structure). The results show that adding molybdenum considerably increased the microhardness and decreased the elastic modulus, with values around 80 GPa, below the metallic materials used commercially for this type of application. From the produced alloys, Ti-50Nb-12Mo is highlighted due to its lower elastic modulus.

Heat Treatment Protocol for Additively Manufactured Nitinol Shape Memory Alloys in Biomedical Applications

Heat Treatment Protocol for Additively Manufactured Nitinol Shape Memory Alloys in Biomedical Applications

Microstructure and Wear Behavior of Heat-Treated Mg-1Zn-1Ca Alloy for Biomedical Applications.

The microstructure and wear properties of a Mg-1wt.% Zn-1wt.% Ca (ZX11) alloy with different heat treatments have been investigated. The ZX11 alloy was tested in the as-cast state and after different heat treatment conditions: solution-treated (at 450 °C for 24 h), peak-aged (solution-treated + aged at 180 °C for 3 h), and over-aged (solution-treated + aged at 180 °C for 24 h). The microstructure of the as-cast sample showed a continuous intermetallic phase at the grain boundaries, while the heat-treated samples exhibited discrete precipitated particles within the grains. To evaluate the wear behavior, the samples were tested using a pin-on-disc configuration, where the wear rates and friction coefficients were measured at different loads and sliding speeds. An AZ31 magnesium alloy was used as the counterbody. The worn surfaces and the wear debris were studied to identify the main wear mechanisms corresponding to each test condition. The results indicated the presence of abrasion, oxidation, and adhesive wear mechanisms in all testing conditions. In the as-cast state, delamination and plastic deformation were the dominant wear mechanisms, while they were less relevant in the heat-treated conditions. The peak-aged samples exhibited the lowest wear rates, suggesting that modifying the distribution of intermetallic precipitates contributed to enhancing the wear resistance of the alloy.

Effect of milling time on structural, physical and tribological behavior of a newly developed Ti-Nb-Zr alloy for biomedical applications

Titanium (Ti)-based alloys with only a β-phase have attracted academic and industrial interest for orthopedic application, due to their close properties to those of tissues. The current study aims to investigate the effect of milling time (2 h, 6 h, 12 h and 18 h) on the nanostructured ternary alloy Ti-25Nb-25Zr prepared by high energy milling, on its structural, physical and tribological behaviors. The alloys’ characteristics such as relative density/porosity, surface roughness, were evaluated using XRD, SEM, surface profilometry, and microdurometer, respectively. The tribological characterization was done using an oscillating tribometer under wet conditions, simulating the human body environment. Results showed that the crystallite and mean pore size reduced with increasing milling time, with the smallest values of 26 nm and 40 µm, respectively after 18 h. Structural characterization shows that the amount of the β-Ti phase increased with increasing milling time, resulting in spherical morphology and texturing of the synthesized alloys. The milled alloys' structural evolution and morphological changes were sensitive to their milling times. Also, the relative density, Young’s modulus and hardness, increased due to grain size decreased with increasing milling time. Tribological results showed that the effect of milling has a significant effect on both nanomaterial formation and friction-wear behavior of the alloys. The results showed that, friction coefficient and wear rate significantly decreased due to the increased formation of protective films such as TiO2, Nb2O5 and ZrO2 phases. The wear mechanism of the Ti-25Zr-25Nb system was dominated by abrasion wear accompanied by adhesion wear.

Effect of low and high temperature ECAP modes on the microstructure, mechanical properties and functional fatigue behavior of Ti-Zr-Nb alloy for biomedical applications

A Ti-18Zr-15Nb (at%) shape memory alloy was subjected to a high-temperature thermomechanical treatment (HTMT) combining an equal channel angular pressing (ECAP) at 500 °C for n = 4–8 passes and a short-time post-deformation annealing (PDA) at 600 °C. The phase composition, microstructure, texture, mechanical and functional properties were studied. The functional fatigue behavior observed in this study was compared to that resulted from the reference low-temperature thermomechanical treatment (LTMT) by ECAP at 200 °C for 3 passes + PDA (600 °C for 5 min). The ECAP at 500 °C (n = 4) led to the formation of a highly deformed, dynamically polygonised substructure of β-phase with a crystallographic texture close to the [101] direction. In this state, the alloy exhibited an excellent combination of the static functional and mechanical properties: a relatively high strength (UTS = 670 MPa), a sufficient ductility (δ = 13.3 %), a low Young’s modulus (E < 40 GPa), and a high superelastic recovery strain (εrsemax= 3.1 %). An increase in the number of passes during ECAP to n = 8 led to a greater substructural hardening of the material, grain/subgrain refinement, and the release of α-phase. This significantly increased the alloy strength (UTS = 897 MPa), but reduced its ductility (δ = 5.9 %) and suppressed martensitic transformation. The alloy after both the HTMT (ECAP at 500 °C, n = 4) and TMT (ECAP at 200 °C, n = 3) processes exhibited an equally excellent functional fatigue resistance accompanied by a superior superelastic behavior with small accumulated strains. However, the HTMT process appears to be more technologically advanced, as it eliminates the need for PDA and reduces the risks of specimen cracking during processing.

Effect of Fe content on physical, tribological and photocatalytical properties of Ti-6Al-xFe alloys for biomedical applications

The aim of the current study is to evaluate the effect of iron content (0, 2, 4, 6 and 10 wt%) on the structural, tribological and photocatalytical properties of a nanostructured ternary alloy Ti-6Al-XFe, prepared by high energy milling. The alloys’ characteristics such as lattice parameters, powder morphologies, surface roughness, relative density/porosity, and microhardness, were evaluated using X-ray diffraction (XRD), scanning electron microscope (SEM), surface profilometry, porosimeter and micro durometer, respectively. The W-H method was utilized to determine the crystallite size. Micro strain was also calculated, which is produced in the lattice due to the diffusion of iron atoms. The photocatalytical characterization was conducted by measuring their absorbance as a function of time using spectrophotometer of visible and ultraviolet light in the wavelength range of 500–800 nm. The tribological characterization was performed using an oscillating tribometer under wet conditions, simulating the human body environment using Phosphate Buffered Saline (PBS) solution with neutral pH 7.4, under different applied loads of 2, 6 and 10 N, respectively. Results showed that the addition of Fe has a significant effect on the structural properties of the developed alloys. The lattice parameter (aα) decreased with increasing Fe content from 2.9493 Å (0 wt% Fe) to 2.9491 Å (10 wt% Fe), while the average grain size increased considerably from 6.965 nm (0 wt% Fe) to 44.42 nm (10 wt% Fe). The wear test results showed that, friction coefficient and wear rate considerably decreased due to the formation of protective films such as TiO2. The photocatalytical characterization showed that, the degradation of methylene blue (MB) increased with increasing Fe content. The Ti-6Al-4Fe -catalyst gave the best degree of degradation of 90.76% within 60 min, which meant that the decolorization process could be operated rapidly at a relatively low cost without UV irradiation.

Synergistic coating strategy combining photodynamic and photothermal properties along with reinforcing corrosion protection fabricated on magnesium alloys

Postoperative infections of bone implants and loss of mechanical strength due to the corrosion are two major obstacles in the pathway for the magnesium alloys applications in biomedical region. To resolve above issues, a novel hybrid coating, MAO/EPR/Gel, is prepared on AZ31B magnesium alloys, in which the photodynamic therapy (PDT) and photothermal therapy (PTT) agents are combined together to form Er@PDA-RB and they are inserted in the micropores of micro-arc oxidation (MAO) coating rather than doping in it. The gelatin is utilized to prevent the leaking of Er@PDA-RB and it would be decomposed spontaneously in the human body. The |Z|0.01Hz of MAO/EPR and MAO/EPR/Gel are 4.35 × 104 Ω cm2 and 6.99 × 104 Ω cm2, which is much larger than that of MAO coating and bare AZ31B Mg alloy with the values of 3.70 × 104 Ω cm2 and 1.50 × 103 Ω cm2, respectively. The antibacterial ratio for E. coli reaches 93.9% under 980nm near-infrared (NIR) irradiation within 60min. Moreover, the MAO/EPR/Gel coating displays the excellent cytocompatibility with the HL-7702 cell viability > 75% with or without 980nm NIR irradiation. This multifunctional integrated coating accomplishes both PDT and PTT functions with only one NIR irradiation without sacrificing the anti-corrosion feature, which exhibits a promising application for magnesium alloys in biomedical applications.