This paper investigates the problem of management, maintenance and planning of interventions in transport networks located in seismic zones, in relation to the actual state of degradation of their most vulnerable elements, as bridges. The study consists in two phases: the first phase is concerned with definition of the seismic vulnerability of a typical bridge in the network, through the construction of fragility curves calculated taking into account the corrosion of the reinforcing steel as the main cause of environmental deterioration. Once the fragility curves of the deteriorated bridges are computed, the second phase consists in the analysis of the vulnerability of the transport network in which the bridges are included taking into account the modification of the traffic flows when bridge infrastructures are damaged. The results of this pilot study can be used as a first step for a proper allocation of economic resources in the planning of seismic retrofit interventions to minimize the overall risk and manage the immediate post-earthquake emergency phase and guide rescuers in reaching the affected and critical areas.