Trends in global financialization, as well as global shocks related to the COVID-19 pandemic, climate changes, intensification of the interstate economic and political competition for limited natural, energy, water, food and skilled human resources, including the global economic recession, political and financial instability negatively affect the state of the economy and public finances of Ukraine. Further strengthening country’s defense capabilities, as well as solving urgent problems in the areas of health, education and science, social and pension provision, and overcoming mass poverty are impossible without scientific substantiation, institutional support, alongside with a broad political, social and popular support for strategic priorities. restoration of economic growth, balancing public finances. Protecting fiscal security at the regional level aims to increase the resilience of the national economy. The authors of the article emphasize that the anti-crisis orientation of territorial redistribution of funds should take into account the requirements of the most rational allocation of productive forces, business promotion, resolving contradictions that arise in balancing budget revenues and constitutional social obligations. The processes of the decentralization of budgetary and tax relations should be accompanied by strengthening their social orientation. The priority of vital national interests is the ability of the state to ensure sustainable development of territories, economic entities, as well as compliance with modern standards of welfare. Improving change management due to the spread of the COVID-19 coronavirus disease requires strengthening the resistance to the unpredictable negative risks of unbalancing most areas of human activity in all aspects, from households to value chains of multinational companies. The formation of stable characteristics of the financial potential of regional development should take place along with the growth of fiscal activity of local governments.