Abstract. The runoff of the Fenhe River flowed into the Yellow River (RRY) is reducing significantly due to the influence of climate change and human activities. It is generating bad situation of shortage of water resources and led to the deterioration of ecological environment of Shanxi Province. At the same time, the reduction in RRY causes the runoff reduction in Yellow River and exacerbated the water resources shortage of the middle area of the Yellow River. Therefore, it is important to alleviate water shortage and develop the soil and water conservation measurements and regional water policy by analyzing the influence of human activities and climate change on the RRY. The existing study quantified the reduction in amount of RRY which caused by human activities and climate change using statistical methods and watershed hydrological model. The main results of the study were as follow: Using hydrological variation diagnosis system, the variation characteristics of long time series of measured annual runoff were analyzed in Hejin station that is the Fenhe River control station. The results showed that the runoff of Fenhe River run into Yellow River declined year by year, in 1971, fell the most obviously. The impact of LUCC on runoff was calculated using the method of area ratio in the Fenhe River basin. Human activities were major factor in the reduction of RRY than the climate change, contributed 83.09 % of the total reduction in RRY, Groundwater exploitation gave the greatest contribution to the decrease in RRY in the scope of several kinds of human activity (30.09 %), followed by coal mining (26.03 %), climate changed contributed 19.17 % of the total reduction of RRY, and the decrease of precipitation contributed 20.81 %. But the variation of air temperature and wind speed would result in the increase of the amount of RRY.