Abstract The cloud cover and meteorological parameters serve as fundamental criteria for an astronomical observatory working in optical and infrared wavelengths. In this paper, we present a systematic assessment of key meteorological parameters at the Lenghu astronomical observing site on the Tibetan Plateau. The datasets adopted includes the meteorological parameters collected at the local weather stations at the site and in the Lenghu Town, the sky brightness acquired by the Sky Quality Meters and all-sky images from a digital camera, the ERA5 reanalysis database and global climate monitoring data. From 2019 to 2023, the fractional observable time of photometric condition is 69.70%, 74.97%, 70.26%, 74.27% and 65.12%, respectively, which is influenced by a variety of meteorological parameters. Large-scale air-sea interactions affect the climate at Lenghu site, which in fact delivers a clue to understand the irregularity of 2023. Specifically, precipitable water vapor at Lenghu site is correlated to both the westerly wind index and the summer North Atlantic Oscillation index, the yearly average temperature of Lenghu site is observed to increase significantly during the occurrence of a strong El Niño event, and the relative humidity anomaly at Lenghu site is correlated to the Pacific Decadal Oscillation index. The decrease of fractional observing time in 2023 was due to the ongoing strong El Niño event and relevant global climate change. We underscore the substantial role of global climate change in regulating astronomical observing conditions and the necessity for long-term continuous monitoring of the astronomical meteorological parameters at Lenghu site.