Alkynyl Sugars Research Articles

Enantiomeric synthesis of pyran subunits of marine trans-fused polyether toxins :Epimerization of Alkynyl sugars through cobalt complexes

Alkynyl group attached on the C-1 position of pyranose ring was epimerized through dicobalt hexacarbonyl complex with trifluoromethanesulfonic acid. Three steps involving complexation, acidic transformation and decomplexation afforded overall epimerization. The driving force of this epimerization based on 1.3-diaxial interaction and 1,2-interaction.