Received: October 2015, Accepted: December 2015 Background: Hospitalization in the coronary care unit (CCU) is a concern for patients and their companions. Different studies have presented conflicting results about the effect of visitors on physiological parameters of patients. The purpose of this study was to determine changes in physiological parameters (systolic and diastolic blood pressure and heart rate) due to presence of visitors at the bedside of patients admitted to CCU at Ali-ibn Abi Talib Hospital of Rafsanjan, Iran. Materials and Methods: This was a cross-sectional study carried out on 281 patients hospitalized in the CCU. Patients’ systolic and diastolic blood pressure and heart rate were obtained using a heart monitoring device 2 hours before, during, immediately, and 2 hours after the visit and were recorded in checklists by nurses. Data were analyzed using two-way repeated measures ANOVA. Results: Mean and standard deviation of patients’ age was 62.96 ± 12.16 years (ranged between 29-93 years). Mean changes in systolic and diastolic blood pressure and heart rate of patients in studied time periods was statistically significant (P 0.050). Average diastolic blood pressure in patients older than 70 years was less than other age groups and average heart rate in patients older than 60 years was higher than younger patients (P < 0.050). Conclusions: The average of physiological parameters increased during visits, but decreased to primary levels 2 hours after visits. These changes were not considered clinically important.