Abstract This research presents a novel simultaneous localization and mapping algorithm, called Focus-SLAM, which simulates human navigation strategies by synthesizing a optical saliency model, SalNavNet, in a traditional single-shot SLAM paradigm. SalNavNet introduces an innovative design that incorporates a correlation module and an adaptive Exponential Moving Average (EMA) component, effectively addressing the prevalent center bias issue found in contemporary saliency models. As a result, the system enhances target fixation by accentuating salient features more effectively. Extensive experimental evaluations, conducted across a spectrum of indoor environments exhibiting diverse luminosity conditions. These findings attest to the efficacy of Focus-SLAM in enhancing both the accuracy and efficiency of SLAM operations under challenging real-world conditions.