Abstract Support vector machine (SVM) is a powerful supervised machine learning model that is often used in binary classification algorithms. As Moore’s Law approaches its theoretical limits and the demand for machine learning to handle large-scale, high-dimensional data analysis intensifies, the necessity of adopting non-traditional computational approaches becomes evident. Quantum computing, in particular, emerges as a vital solution for the effective training of SVM models, providing capabilities beyond those of classical computing systems. To solve the above problems, a QUBO (quadratic unconstrained binary optimization) model is proposed to transform the SVM machine learning model into a quadratic unconstrained binary optimization problem so that they can be effectively trained on the D-Wave platform using adiabatic quantum computer. The results show that the QUBO model can transform the SVM model into a simple quadratic programming problem, which makes it suitable for adiabatic quantum computer processing. When processing large-scale and high-dimensional data, this transformation shows a natural advantage and significantly improves computational efficiency. The application potential of this transformation technology is huge in the medical field.