You have accessJournal of UrologyBenign Prostatic Hyperplasia: Medical and Hormonal Therapy1 Apr 20121260 A PROSPECTIVE RANDOMIZED STUDY COMPARING THE EFFICACY OF TAMSULOSIN, ALFUZOSIN AND PLACEBO IN THE MANAGMENT OF ACUTE URINARY RETENTION SECONDARY TO BENIGN PROSTATIC HYPERPLASIA Miguel Maldonado-Avila, Jose Alfredo Sierra-Ramirez, Hugo Arturo Manzanilla-Garcia, Juan Carlos Gonzalez-Valle, Emmanuel Rosas-Nava, and Isaac Labra-Salgado Miguel Maldonado-AvilaMiguel Maldonado-Avila México City, Mexico More articles by this author , Jose Alfredo Sierra-RamirezJose Alfredo Sierra-Ramirez México City, Mexico More articles by this author , Hugo Arturo Manzanilla-GarciaHugo Arturo Manzanilla-Garcia México City, Mexico More articles by this author , Juan Carlos Gonzalez-ValleJuan Carlos Gonzalez-Valle México City, Mexico More articles by this author , Emmanuel Rosas-NavaEmmanuel Rosas-Nava México City, Mexico More articles by this author , and Isaac Labra-SalgadoIsaac Labra-Salgado México City, Mexico More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2012.02.1578AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Acute urinary retention (AUR) is a common urological emergency in men and is defined as a sudden and painful inability to pass urine voluntarily. In most cases, no triggering event is identified and the AUR is attributed to the natural history of benign prostatic hyperplasia (BPH). Managment of AUR involves immediate bladder catheterization usually followed by prostatic surgery, with a greater morbidity and mortality associated with emergency surgery (within few days after AUR) and the potential morbidity associated with prolonged catheterization (bacteriuria, fever, urosepsis). To the date, the first line of treatment in this patients is the use of a trial without catheter (TWOC) with a previous administration of an alpha-blocker that should increase the likelihood of success. To evaluate and compare the efficacy and safety of tamsulosin and alfuzosin as compared to placebo in patients with AUR secondary to BPH. METHODS Patients with acute urinary retention due to BPH (total 83), were catheterized and randomized into three groups with a ratio 2:1 with respect to placebo: Group I: Tamsulosin 0.4 mg( 33 patients), Group II: Alfuzosin 10 mg (31 patients), Group III: Placebo (19 patients). After four days, catheter was removed, and patients were put on trial without cathether (TWOC). A TWOC was considered succesful if the patient had a voided volumen >100 ml and post-voidal residual urine <200 ml. RESULTS TWOC was succesful in 45 % (15) of the patients in the tamsulosin group, 38 % (12) in the alfuzosin group and 26% (5) in placebo group. Logistic regresión analysis showed that both drugs are as effective and the alpha-blocker is not a predictor factor of success of TWOC (p= 0.484) (OR 1.233, IC 95 % 0.686 - 2.214). CONCLUSIONS TWOC was more successful if treated with alfuzosin or tamsulosin as compared to placebo. Tamsulosin was found to be as effective as alfuzosin, but the success rate for both drugs is inferior to previous reports. © 2012 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 187Issue 4SApril 2012Page: e509-e510 Advertisement Copyright & Permissions© 2012 by American Urological Association Education and Research, Inc.MetricsAuthor Information Miguel Maldonado-Avila México City, Mexico More articles by this author Jose Alfredo Sierra-Ramirez México City, Mexico More articles by this author Hugo Arturo Manzanilla-Garcia México City, Mexico More articles by this author Juan Carlos Gonzalez-Valle México City, Mexico More articles by this author Emmanuel Rosas-Nava México City, Mexico More articles by this author Isaac Labra-Salgado México City, Mexico More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...