Alcohol Withdrawal In Patients Research Articles

CSF levels of norepinephrine during alcohol withdrawal.

Cerebrospinal fluid norepinephrine (NE) levels were determined by radioenzymatic assay in 21 patients with a variety of neurological diseases and 49 patients in acute alcohol withdrawal. A second determination was made in 19 patients who had recovered from the alcohol withdrawal syndrome. Cerebrospinal fluid NE concentration was higher in the patients during alcohol withdrawal (192.3 plus or minus 22.3 pg/mL) and decreased during recovery to 137.8 plus or minus 15.9 pg/mL. The CSF NE level was higher in both groups than in patients with other neurological disorders. This may help explain the adrenergic signs observed during alcohol withdrawal.

Quantitative changes of signs and symptoms associated with acute alcohol withdrawal: incidence, severity and circadian effects in experimental studies of alcoholics.

A quantitative phenomenological approach to the alcohol withdrawal syndrome in man offers major advantages to the investigator and clinician that are not provided by the current nosology of the withdrawal. These advantages have been discussed at length elsewhere (Gross et al., 1974). A clinical instrument was developed for the purpose of a quantitative phenomenological assessment of the alcohol withdrawal syndrome, the Total Severity Assessment of alcohol withdrawal (TSA). This instrument was based on a review of the literature, observations over thirteen years of approximately fifteen thousand patients in alcohol withdrawal, and extensive clinical trials, several of which have been reported (Gross et al., 1968, Gross et al., 1971a, Gross et al., 1971b, Gross et al., 1973, Gross et al., 1974). The TSA has been applied in experimental studies of intoxication and withdrawal in alcoholic volunteers. In an earlier communication, the prevalence of the signs and symptoms associated with acute alcohol withdrawal during experimental studies were reported (Gross and Lewis, 1973). This communication will examine the incidence and severity of the signs and symptoms during experimental studies of intoxication and withdrawal in an enlarged sample. Circadian effects on temperature changes will also be described.KeywordsHeavy DrinkingAlcohol WithdrawalBlood Alcohol ConcentrationAlcohol IntoxicationAlcohol Withdrawal SyndromeThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Hallucinations and Clouding of Sensorium in Alcohol Withdrawal; Some Demographic and Cultural Relationships

Among patients in alcohol withdrawal, the less educated, those with higher body temperature and those with fewer previous hospitalizations had more clouding of the sensorium. More of those with clo...

Grand-Mal Seizures in Two Patients in Acute Alcohol Withdrawal after Treatment with Hydroxyzine

Grand-Mal Seizures in Two Patients in Acute Alcohol Withdrawal after Treatment with Hydroxyzine