Alcohol During Pregnancy Research Articles

Alcohol Use in Pregnancy, Redux

Although alcohol use during pregnancy has been associated with neurodevelopmental consequences in offspring, most studies have emphasized the dangers

Pregnancy Decreases Risk for Alcohol Use Disorder

About 10% of women in the U.S. report using alcohol during pregnancy (about 2% binge drink); use is higher earlier in pregnancy, possibly because women

Analysis of detection rate and risk factors for congenital malformation among neonates

Objective To analyze the detection rate of neonatal congenital malformation, and to explore the risk factors for neonatal malformation. Methods A total of 29 831 infants born in Shenzhen People′s Hospital from January 2011 to December 2015 were analyzed retrospectively, the detection rate of congenital malformations was calculated, 381 infants with congenital malformation were selected as malformation group, and 381 healthy infants were selected as healthy control group, and the risk factors of congenital malformation were analyzed. Results A total of 381 infants with congenital malformation were screened out, the incidence rate of congenital malformation being was 12.77‰(381/29 831 cases). The incidence rates of multi-finger or multi-toe, cleft lip, congenital heart disease were the high, which were 18.64%(71/381 cases), 17.32%(66/381 cases) and 16.80%(64/381 cases), respectively.The multiple Logistic analysis showed that birth children with low weight newborns( 1, low literacy levels of mothers, living in towns, late childbirth(≥35 years of age), pregnancy syndrome, viral infection during early pregnancy, medication history during pregnancy, rubella unvaccinated, exposure to harmful substance, smoking and alcohol during pregnancy and paternal smoking, chronic diseases, total 16 items were related risk factors for neonatal congenital malformations(all P<0.05). Among them, the impact of viral infection during early pregnancy, alcohol, smoking, pregnancy syndrome, exposure to harmful substance, medication history during pregnancy on the incidence of malformations in neonates was relatively serious. Conclusions The incidence rate of congenital malformations among neonates conforms to the present situations in China, which was closely correlated with genetic and environmental factors.Health education targeting pregnant women and the women of childbearing age should be carried cut to reduce the birth of neonatal congenital malformations. Key words: Infant, newborn; Congenital malformation; Risk factor; Logistic regression analysis

Conclusion Overreach in Alcohol and Pregnancy Article: The Authors Reply.

Conclusion Overreach in Alcohol and Pregnancy Article: The Authors Reply.

High Prevalence of Comorbidities with Fetal Alcohol Spectrum Disorder

Maternal exposure to alcohol during pregnancy can cause damage to the fetus beyond morphological abnormalities, resulting in fetal alcohol spectrum

Effects of hyperacetylation of H3K9ac mediated by histone acetylases on the overexpression of MEF2C induced by alcohol in the hearts of fetal mice during pregnancy

Objective To investigate the effects of H3K9ac hyperacetylation mediated by histone acetylases on the overexpression of MEF2C in the hearts of fetal mice exposed to alcohol during pregnancy, and provide new intervention targets for prevention and treatment of cardiac dysplasia caused by alcohol exposure. Methods C57BL/6 mice were divided into 5 groups randomly, blank control group, dimethylsulfoxide (DMSO) group, alcohol group, alcohol+ anacardic acid group and anacardic acid group, and then the hearts of fetal mice were collected to be analyzed.Chromatin immunoprecipitation and Western blot were used in assaying the binding of histone acetylases and the level of H3K9ac to the promoter of MEF2C in the hearts of fetal mice.The mRNA expression of MEF2C was tested by adopting real-time PCR. Results The level of H3K9ac in the promoter of MEF2C in the hearts of fetal mice exposed to alcohol was higher than that in the hearts of fetal mice exposed to saline (1.30±0.19 vs 0.45±0.01), there was statistically significant difference (P<0.05), while the binding of E1A-binding protein (p300), p300/cyclic adenosine monophosphate response element binding protein-associated factor (PCAF) and steroid receptor coactivator-1 (SRC1) to the promoter of MEF2C were abnormally elevated in the hearts of fetal mice treated by alcohol (1.68±0.08 vs 0.82±0.08, 1.08±0.05 vs 0.42±0.02, 1.18±0.05 vs 0.39±0.08), and there were statistically significant differences (all P<0.05). The expression of MEF2C mRNA in alcohol group was higher than that in blank control group (1.36±0.12 vs 0.29±0.03), there was statistically significant difference(P<0.05). However, a pan-acetylases inhibitor, anacardic acid, could decrease significantly the binding of p300 and PCAF to the promoter of MEF2C (1.52±0.05 vs 0.63±0.09, 1.13±0.04 vs 0.45±0.04), and correct abnormal hyperacetylation of H3K9ac induced by alcohol (1.58±0.08 vs 0.67±0.05), and down-regulate the over-expression of MEF2C in the hearts of fetal mice exposed to alcohol (1.36±0.12 vs 0.41±0.05), and there were statistically significant differences (all P<0.05). Conclusions Hyperacetylation of H3K9ac mediated by p300 and PCAF may be a key regulatory factor in the over-expression of cardiac nuclear transcription factor MEF2C in the hearts of fetal mice exposed to alcohol during pregnancy.Anacardic acid can significantly attenuate the level of H3K9ac through inhibiting the binding of p300 and PCAF to the promoter of MEF2C, and down-regulate the over-expression of cardiac nuclear transcription factor MEF2C in the hearts of fetal mice. Key words: Histone acetylases; Transcription factor; Alcohol; Acetylation; Overexpression

Smokers significantly more likely than others to drink alcohol during pregnancy

Smokers significantly more likely than others to drink alcohol during pregnancy

Share with women. Alcohol and pregnancy.

Share with women. Alcohol and pregnancy.

Renal dysfunction in fetal alcohol syndrome: a potential contributor on developmental disabilities of offspring.

Renal dysfunction in fetal alcohol syndrome: a potential contributor on developmental disabilities of offspring.

Alcohol and pregnancy: the midwives’ precious role and the need to involve partners…

Alcohol and pregnancy: the midwives’ precious role and the need to involve partners…

Testicular growth and testosterone levels in male wistar rat offspring exposed to alcohol during pregnancy and/or lactation

The effect of alcohol on testicular growth and testosterone levels in male rat offspring whose dams were exposed during pregnancy and/or lactation was investigated. Seventy-five adult female Wistar rats and their offspring were used. The female rats were divided into 3 groups of 25 each. The offspring of group 1 served as control, the offspring of group 2 was exposed to 2g/kg body weight of 30% ethanol (v/v) during pregnancy and lactation (APL) while those of group 3 was exposed to the same dose of ethanol during lactation only (AL).. At Day (D)7, D14, D21, D35 and D49 of postnatal life, 5 male offspring were randomly selected from the three groups and sacrificed. After the sacrifice, the two testes were dissected out and their weights determined. At D21, D35 and D49, blood sample for testosterone determination was collected from 5 male offspring. The result of the investigation showed significant reduction (P<0.05) in relative weights of the testes and significant increase (P<0.05) in testosterone levels in the alcohol-exposed male offspring relative to the controls. The reduced testicular weights and increased testosterone levels which persisted into adulthood may have implications for male fertility in offspring of dams who abuse alcohol during pregnancy and/or lactation.

Beware of Alcohol During Pregnancy

Preclinical and clinical research strongly supports the avoidance of alcohol in pregnancy. For example, in animals, the equivalent of a single drink produces irreversible neuronal death (Neurobiol Dis 2006; 22:548), and rats exposed to alcohol in utero have enhanced responses to its taste and smell (JW Psychiatry May 11 2009). In a well-designed prospective study in …

Supporting the message: ‘alcohol and pregnancy don't mix’

Women are faced with conflicting advice on how much alcohol is safe in pregnancy so in November 2008, Alcohol Focus Scotland ran a campaign to deliver their message that ‘alcohol and pregnancy don't mix’.

Re: Alcohol and pregnancy: The pivotal role of the obstetrician

Re: Alcohol and pregnancy: The pivotal role of the obstetrician

Head Injury in Young Children Likely Is a Marker, Not a Cause, for ADHD

Genetics is important in the development of attention-deficit/hyperactivity disorder (ADHD), but the role of other factors — such as maternal drug and alcohol use during pregnancy, other toxin exposures, or injury — is not known. To assess whether head injury is a cause of ADHD, researchers retrospectively analyzed …

Binge Drinking During Early Pregnancy

Most women avoid alcohol during pregnancy, but some might engage in risky behaviors before realizing that they are pregnant. The risks associated with alcohol consumption differ at various times during pregnancy. In a study using the Danish National Birth Cohort, researchers evaluated the association between binge drinking (consuming ≥5 alcoholic drinks on a single occasion) during early pregnancy and risk for fetal death. The investigators …

EMJA: Alcohol in pregnancy: how safe is it?

eMJA: Alcohol in pregnancy: how safe is it?

Principales factores de riesgo asociados a las gestantes adolescentes de la Comunidad Valenciana

SUMMARY Objective: To study the main risk factors associated with adolescent pregnancy in the Valencian Community. Material and methods: A descriptive epidemiological analysis of the 104 pregnancies of 98 adolescents which occurred in a five year period (between June 1995 and May 2000) in the Marina Alta district, province of Alicante, of the Valencian Community. In order to know the risk factors associated with adolescent pregnancy, we studied tobacco and alcohol consumption, obesity, arterial hypertension, diabetes mellitus, and other diseases such as asthma, epilepsy, and sexually transmitted diseases. Results: 15 smoker were found (14.42%); 7 other patients (6.73%) smoked occasionally and 82 (78.84%) were non smokers. Up to 25 patients (24.03%) said they drank alcohol very occasionally and 79 patients (75.96%) did not drink alcohol. No cases of obesity, hypertension, or diabetes mellitus were found amongst the adolescent patients. Two patients suffered from asthma (1.92%) and another patient suffered from epilepsy (0.96%). We found two patients (1.92%) with hepatitis B positive markers, one of whom was HIV positive and one patient had vulvar condilomas removed. Conclusions: the percentage of adolescent smokers is lower, and the percentage of women who said they had drunk alcohol pregnancy is comparanle to that found in other samples of pregnant adolescents. INTRODUCCION La adolescencia, definida como transicion entre la infancia y la edad adulta, es un periodo critico. Muchos autores delimitan esta etapa de una forma imprecisa 1,2 , pero la Organizacion Mundial de la Salud (OMS) define a la adolescencia como la etapa comprendida entre los 10 y los 19 anos 3 .

Alcohol Consumption During Pregnancy on the Rise

The dangers of drinking alcohol during pregnancy are well known to doctors and widely broadcast to the public. However, a CDC telephone survey

NHMRC recommendations on abstinence from alcohol in pregnancy

NHMRC recommendations on abstinence from alcohol in pregnancy