The incidence of patients with end-stage renal failure and type 2 diabetes mellitus as a comorbid condition has increased progressively in the past decades. Causes of renal disease might vary from one population to another. The aim of this study was to know the characteristics of the diabetic patients on regular dialysis at Al-noor Specialist Hospital, Makkah, Saudi Arabia. The data had been collected retrospectively in the month of Shawal 1425 corresponding to 13-11-2004----12-12-2004 from the diabetic patients directly that were on dialysis due to end stage renal disease (ESRD) and from their files. The mean age of Diabetics was (55.2 years) showing male predominance 31 (60.8%). All were Saudies. The mean duration of Diabetes mellitus & dialysis were (16.8 years) and (22 months), respectively. The mean age of start of Diabetes mellitus & dialysis was (37.4 years) & (53.5 years). The mean duration of onset of diabetes to dialysis was (16.1 years). Out of the total, 29 (56.9%) were non-smoker. Patients with family H/O diabetes with other associated illnesses were 23 (45%) followed by 15 (29.4%) had family H/O only diabetes. Type II diabetics were 40 (78.4%). Regarding metabolic profile, patients with high blood glucose level were 10 (19.6%) while 3 (5.9%), 50 (98%) & 18 (35.3%) patients had high cholesterol, low density lipoprotein & triglyceride levels, respectively. Maximum patients were in sixth decade of life. Up to three fourth patients had family H/O diabetes. Most of the subjects had only diabetic nephropathy Maximum patients had high low density lipoprotein level. Dialysis was main treatment to control diabetes.