The burden of care among caregivers has emerged as a significant public health concern. This study investigated demographic factors and perceived social support as predictors of the burden of care among family caregivers of children living with HIV (CLHIV) in Akwa Ibom State. Fifty-seven participants, comprising 6 males (10.53%) and 51 females (89.47%), were purposively selected from rural family caregivers receiving family support services from selected Non-Governmental Organisations (NGOs) in Akwa Ibom State. A cross-sectional survey design was employed, utilizing the Perceived Social Support Scale and the Burden of Care Scale for data collection. Descriptive statistics and multiple regression were used for data analysis. Results indicated that age significantly predicted the burden of care among family caregivers of CLHIV (β = .322; t = 2.50, P < .05). However, caregivers' education (β = .031; t = .235; P > .05) and relationship with the care recipient (β = -.077; t = -0.58; P > .05) did not predict the burden of care. Notably, perceived social support independently predicted the burden of care (β = .292; t = 2.29; P < .05). Furthermore, a significant joint prediction of demographic factors and perceived social support on the burden of care of family caregivers of CLHIV was found (F = (6,56) = 2.82; P < .05). The findings highlight the need for targeted interventions and support programs that address caregivers' needs, particularly in terms of social support networks, to alleviate the burden associated with caring for children living with HIV.