The present study was implemented to remediate heavy metal levels in lettuce grown by Akaki river water in 45 pots. The soil for the pot experiment collected from the Akaki area and the water used for lettuce growing from the upper, middle, and lower part of Akaki River with five treatment for three locations: groundwater (control), 25, 50, 75, and 100% Akaki river water with groundwater combination set as treatment. The results obtained from this pot experiment in lettuce samples Cd, Pb, Fe, Zn, Cr, and Cu concentration in the range of (0.047-0.263), (0.42-6.55), (339.83-420.00), (2.96-13.44), (0.95-7.87) and (1.68-7.49) (mg /Kg) respectively, all heavy metal concentration except groundwater irrigated lettuce sample above-recommended level set by WHO (1999). Whereas, Concentration of these metals in the soil samples (mg/kg) was found to be Cd (0.47-3.47), Pb (8.00-118.00), Fe (13557.30-16800.00), Zn (40.00-224.67), Cr (4.91-39.36) and Cu (35.00-149.88), out of Cd and Fe heavy metal concentration in Akaki river water irrigated soil samples except 100% Akaki river water irrigated soil sample was below the recommended level set by /FAOWHO (2001). Similarly, concentrations (mg/L) of the metals in the Akaki river water samples were found to be in the ranges of 0.18-0.28, 1.40-2.67, 0.97-1.40, 0.037-0.087, 0.037-0.080, and 01-0.14 for Fe, Zn, Cu, Cd, Pb, and Cr, respectively. The concentrations of heavy metals in the Akaki river water and lettuce samples were above the recommended limit of both WHO and FAO. Also, Cd and Fe for the soil samples were greater than WHO and FAO recommended limit. Based on facts obtained from this study we suggest concerned official body (ies) take the necessary precaution measures for cleaning the Akaki river water.