Cold-formed steel channel (CFSC) sections have gained widespread adoption in building construction due to their advantageous properties, including superior energy efficiency, expedited construction timelines, environmental sustainability, material efficiency, and ease of transportation. This study presents a numerical investigation into the axial compressive behavior of CFSC section columns. A rigorously developed finite element model for CFSC sections was validated against existing experimental data from the literature. Upon validation, the model was employed for an extensive parametric analysis encompassing a dataset of 208 CFSC members. Furthermore, the efficacy of the design methodologies outlined in the AISI Specification and AS/NZS Standard were evaluated by comparing the axial load capacities obtained from the numerically generated data with the results of four previously conducted experimental tests. The findings reveal that the codified design equations, based on nominal compressive resistances determined using the current direct strength method, exhibit a conservative bias. On average, these equations underestimate the actual load capacities of CFSC section columns by approximately 11.5%. Additionally, this investigation explores the influence of eccentricity, cross-sectional dimensions, and the point-of-load application on the axial load capacity of CFSC columns. The results demonstrate that a decrease in section thickness, an increase in column length, and a higher degree of eccentricity significantly reduce the axial capacity of CFSC columns.