SESSION TITLE: Allergy and Airway SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/10/2018 01:00 PM - 02:00 PM PURPOSE: Angioedema refers to abrupt nonpitting swelling of the skin or mucous membranes that can involve the upper respiratory and gastrointestinal tracts. Episodes can be triggered by medications, foods, or even sun exposure, although most cases remain idiopathic. Hospital admission data in the United States indicates rising incidence in all-cause angioedema during the past several decades. This study attempts to estimate trends in disease severity, and associated healthcare costs in patients hospitalized with angioedema from 2005 to 2014. METHODS: This is a retrospective cohort study using the 2005-2014 National Inpatient Sample. The inclusion criteria were patients over the age of 18. Elective admissions were excluded. The primary outcome was the temporal change of hospitalizations for all-cause angioedema based on validated ICD9-CM codes. In the secondary analysis, we examined the trend of in-hospital mortality, morbidities and resource utilization for angioedema. The in-hospital morbidities included anaphylactic shock, requirement for mechanical ventilation requiring ICU admission. Adjusted odds ratios (aOR) were calculated based on multivariate logistic analysis adjusted for age, gender, race, Charlson Comorbidity Index and specific comorbidities (urticaria, allergies and asthma). Hospitalization charges were adjusted for inflation and analyzed using poisson regression analysis. Analysis was performed by using Stata, version 14.2. RESULTS: 224.3 million patients were included in this study. There was a increasing trend in the incidence of angioedema requiring hospitalization from 2005 (4.8/10000 admissions) to 2014 (7.2/10000 admissions in 2014, aOR 1.05, p<0.0001). Among patients admitted for angioedema, the in-hospital mortality rate remained stable (0.45% in 2005 vs 0.49% in 2014, aOR 0.98, p=0.667). However, there was an increasing trend in anaphylactic shock (1.01% in 2005 vs 1.77% in 2014, aOR 1.08, p=0.002), mechanical ventilation (7.01% in 2005 vs 17.97% in 2014, aOR 1.12, p<0.0001) and ICU admission (7.01% in 2005 vs 18.07% in 2014, aOR 1.12, p<0.0001). There was an increase in total hospital charges annually despite adjustment for inflation (crude charge $10537.34 in 2005 vs. $26184.79 in 2014, p<0.001). CONCLUSIONS: The incidence of angioedema requiring hospitalization increased significantly from 2005 to 2014, with increasing morbidities including anaphylactic shock, requirement of intubation and mechanical ventilation despite unchanged mortality rate. This accompanied with an increasing burden in the US health system with lengthier hospital stay and higher hospital charges. CLINICAL IMPLICATIONS: Our study demonstrated a steady increasing trend of incidence and severity of angioedema despite similar mortality rate. Airway management of patients with angioedema may be quite challenging, and the overall increasing severity of angioedema carries a heavier burden in the healthcare system. DISCLOSURES: No relevant relationships by Di Pan, source=Web Response No relevant relationships by tal shachi, source=Web Response No relevant relationships by Avinash Singh, source=Web Response No relevant relationships by Yumeng Wen, source=Web Response
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