SESSION TITLE: Abstracts - Monday Award Semifinalists SESSION TYPE: Original Investigation Posters PRESENTED ON: 10/21/2019 02:30 PM - 03:15 PM PURPOSE: Bronchoscopy is a widely utilized procedure for the diagnosis and treatment of pulmonary disorders. Because of concerns for maternal and fetal safety, data on bronchoscopy in pregnancy is limited to published case reports. In this study, we performed a case series to review the safety and efficacy of bronchoscopy in the pregnant population. METHODS: A systematic literature search was performed using PubMed, EMBASE and Google scholar with key words “bronchoscopy” and “pregnancy”. Case reports involving bronchoscopy performed during pregnancy from January 1984 to December 2018 were included. Our primary objective is to evaluate the diagnostic yield of bronchoscopy in the pregnant population and the secondary objectives are to assess the occurrence of adverse events during the procedure and technical success (completion of procedure). RESULTS: Review of available literature yielded a total of 61 patients, with a mean age of 28±5 (range 18-38 years), and a mean age of gestation (AOG) of 22±8 weeks (range 6-37 weeks). Of these patients, 18% (n=11) were in the 1st trimester, 33% (n=21) in 2nd trimester, 41% (n=15) in 3rd trimester, and the remaining 8% (n=5) were not reported. The main indications for bronchoscopy were: mass (n=26, 44%), hemoptysis (n=15, 25%), unexplained dyspnea/hypoxia (n=10, 16%). Bronchoscopy was performed in 49 stable patients and 12 critically ill patients. Bronchoscopic findings were reported in 51 patients (83%), and a diagnosis was made through bronchial airway lavage and biopsy in 32 out of 41 patients (78%). Major adverse events included: hemoptysis requiring subsequent bronchoscopy or surgery (n=4, 6.5%), spontaneous abortion (n=2, 3.3%), and maternal death (n=1, 1.6%). Minor adverse events included: transient maternal hypotension (n=1, 1.6%), transient maternal hypoxia (n=1, 1.6%), and uterine contractions (n=2, 3.3%). Adverse outcomes of spontaneous abortions and maternal death occurred in patients with critical illness and in whom emergent procedure was done. Technical success was noted to be 100%. CONCLUSIONS: Diagnostic yield of bronchoscopy in pregnancy is high. Bronchoscopy is low risk for adverse events in the general population. The physiologic changes seen in pregnancy can pose an increased risk for adverse events, therefore current recommendations are to defer bronchoscopy until termination of pregnancy, or until after 2nd trimester of pregnancy. Based on our results, bronchoscopy in pregnant patients has minimal adverse outcomes, with risks occurring only in the most unstable patients. CLINICAL IMPLICATIONS: Our study demonstrates that bronchoscopy is safe in pregnancy, with high diagnostic yield and technical success, and minimal inherent adverse outcomes if performed for the right clinical indications. DISCLOSURES: No relevant relationships by Elizabeth Au, source=Web Response No relevant relationships by Jacqueline Choa, source=Web Response No relevant relationships by Chad Cross, source=Web Response No relevant relationships by Banreet Dhindsa, source=Web Response No relevant relationships by Rajany Dy, source=Web Response