In this study, we present the possibility of substituting the primary fluid Freon 11 (CCl3F, R11) used in the experimental thermohydraulic test facility which offers the advantage to obtain phase change at relatively low heat fluxes and pressure if compared to water working fluid. Nevertheless, R11 is a CFC (Chlorofluorocarbures) part of the gases that contribute to the degradation of the ozone layer.For this purpose, four working fluids (non-CFC) are judiciously selected to replace the R11, namely the R123, R134a, R143a and CO2, and this through multidimensional Computational Fluid Dynamics (CFD) modeling of steady state flow boiling phenomenon. The calculation model covers a wide range of mass fluxes (435 – 1443 kg/m2s) and heat fluxes (1.2– 36 W/cm2); it predicts the heat transfer rates and transitions points for each flow regime. In this research, the experiment's data were compared to the outcomes of Ansys-CFX computations, using a steady Reynolds-Averaged Navier-Stokes (Steady-RANS) model, to investigate the best replacement refrigerant for R11. The turbulence effects on the mean flow and near wall are taken into consideration using the Shear Stress Transport (SST k-ω) turbulence model. The results from the four fluids were transposed to their water equivalent and compared to those deduced from the experimentation and correlations available in the literature to select the appropriate substitution fluid. The results qualitative and quantitative for vertical and horizontal subcooled boiling flow at the CHF location show that, the most effective surrogate fluid is R123 (HCFC), is still widely used in the refrigeration and air-conditioning industry, then R134a (HFC), then R143a (HFC).