Although many different designed air-assisted sprayers can be used for pesticide application in apple orchards, the lack of adequate adjustments according to specific crop characteristics leads to application inefficiencies and failures. To evaluate the spray coverage and biological efficacy of different application techniques combined with an alternative dosage adjustment based on tree row volume (TRV), field tests with five different techniques were carried out at three crop stages on a commercial apple orchard. The results showed that conventional mist-blower with a high application volume (800 L ha−1) exhibited an excessive coverage with a high risk of contamination at the early crop stage (BBCH19), whereas other treatments using different application techniques, with a reduced volume rate and pesticide dose of 75%, were equivalent with good uniformity, revealing the great importance of suitable adjustment for the sprayers. For the middle and late stages (BBCH64 and 75), the orchard sprayer equipped with vertical booms provided the maximum coverage, and the pneumatic sprayer achieved significantly higher impacts density, which revealed their advantages and high efficiency for dense apple trees. The newly developed multi-fan sprayer and pneumatic sprayer achieved consistent coverage during the entire crop stage, independent of the changes in canopy structure (TRV). This indicates that a suitable setting and adjustment of the sprayer can contribute to a consistent spray quality. In general, benefiting from these new spraying technologies, an average reduction of 60.7% in pesticide dose and volume rate were achieved within the entire season, maintaining the same threshold of pest and disease control as that of the higher reference dose normally applied. These results demonstrate the importance of an alternative dose adjustment method to meet the requirements of the Farm to Fork strategy.