BackgroundDespite the availability of conventional medicine, Mauritians have a deep-rooted interest in the use of traditional herbal medicines (THMs) for the management of diseases. Nonetheless, there is currently a dearth of study that specifically addresses the extent of use of THMs among cardiovascular patients. PurposeTo document THMs employed against cardiovascular diseases (CVDs) and to highlight cultural similarities and differences in their use among different religious groups. MethodsInformants (n = 384) were recruited via a face-to-face interview using a semi-structured questionnaire. Quantitative indexes, (frequency index (FI), informant consensus factor (ICF), cultural importance index (CII), and Jaccard similarity index (JSI)) were calculated. Pearson Chi-Squared test was performed to measure the relationship between demographic characteristics and use of TMs. ResultsOne hundred plants and 19 polyherbal formulations (PHF) were reported to be used against CVDs. Fruit (42.8 %) was the most used plant part and juice (27.8 %) was the most frequently reported method of preparation of plant based remedies. Based on the FI, Citrus limon scored the highest value (FI = 9.1). Hypertensive disease category was the most cited ailment category with the highest informant consensus factor (ICF = 0.65). The CII showed that Ocimum tenuiflorum, Camellia sinensis, Murraya koenigi, and Citrus limon were the culturally most important plants among Hindu, Muslim, Christian, and Buddhist, respectively. The highest similarity of plant usage was between the Hindu and Muslim community (JSI = 90.9). ConclusionsThis research provides a basis of comparative preliminary documentation and analysis of therapies used to treat CVDs. More research is needed with a focus on pharmacological investigations to discover useful bioactive constituents.