AbstractAnthropogenic climate change induced weather and climate extremes have led to frequent heat waves, droughts and floods threatening water resources and food security for an agricultural country like Pakistan. Despite their significance, the trends and variability of extreme temperature and precipitation indices and associated large‐scale drivers in the agro‐ecological zones (AEZs) of Pakistan remain unknown and need urgent attention because of abrupt climate change. The present study documents the spatiotemporal variations of climate change indices together with the elevation‐dependent variability trends over various AEZs in Pakistan for the period of 42 years (1979–2020). Nonparametric Mann–Kendall (MK) and Sen's slope (SS) estimator tests have been employed for trend estimation. Results indicated linearly increasing (warming) and statistically significant trends in Tmean, TNx, WSDI and TR20 whereas significant decreasing (cooling) trends in cool nights (−1.73 days·decade−1) and cold spells (−1.28 days·decade−1). The spatial distribution of temperature indices trends depicts robust warming over southwestern and central zones while cooling trends over northern zones. Regarding precipitation extremes, all indices have shown increasing (wetter) trends with a significant increase in PRCPTOT and RX5day. The stations in northern and subhumid AEZs received more precipitation compared to other zones. Elevation‐dependent trends in temperature indices exhibited a statistically significant positive (negative) relationship with cold (warm) tails. Most of the extreme precipitation indices have a weak, but positive association with elevation except SDII. The weakening of South Asian subtropical upper‐level jet by a high‐pressure system over northeast Pakistan resulted in amplified land surface temperatures. However, the spatial patterns of zonal winds indicate a trough over Pakistan's southern and central parts, with warmer sea‐surface temperature, low sea‐level pressure and easterly anomalies, favour moisture transport and precipitation in Pakistan. The outcomes of present study will be useful in addressing various climate‐induced disasters occurring in various AEZs of Pakistan.