Microencapsulation is a process in which active substances are coated by extremely small capsules. It is a new technology that has been used in the cosmetics industry as well as in the pharmaceutical, agrochemical and food industries, being used in flavours, acids, oils, vitamins, microorganisms, among others. This paper provides an UpToDate review of different microencapsulation methods and polymers used specifically for Celecoxib drug. As Celecoxib is poorly soluble in water, there are several methods used to improve solubility and bioavailability using various polymers. The different microencapsulation methods along with different polymers were studied and given a comprehensive review. There are several NSAIDs which are used for pain management and Celecoxib is a non-steroidal anti-inflammatory drug used in the treatment of osteoarthritis, rheumatoid arthritis, acute pain, painful menstruation, and menstrual symptoms. There are many techniques available that can be used to fabricate microcapsules based on desired characteristics, and applications of the final microcapsule formulation. For Celecoxib microencapsulation, Spray drying techniques are widely used method for the research studies. some of the advantages of spray-drying include its ability to be fully automated and continuous.