Participatory impact assessment of ticks on Borana cattle milk production was conducted from January 2010 to July 2010. The objectives of this study were to assess the status of tick infestation in relation to climate change, teats blinding and milk production and to estimate the economic losses caused as a result of the effect of ticks on dairy cattle and its implications on food security in Yabello, Moyale and Meo districts of Borana zone. Multi-stage sampling technique was employed and the data was analyzed using descriptive statistics and matrix triangulation. Thus, about six villages “ Ollas ” were systematically identified and a total of 86 households were interviewed employing questionnaires comprising 6-12 pastoralists and agropastoralists per ten PAs which in sum contained 60-120 individuals who provided information pertaining to the objectives set; in which increase of ticks population at an alarming rate was perceived having several factors affecting and its real impact of blinding on teats which signal loss of milk production which in fact revealed economic loss and implicated food insecurity on vulnerable social groups, specifically children and elders >80 years old within the settings. Tick resistance to currently available acaricides was complained by communities. It was observed that acaricides were sold in open market and there was no strong control on illegal veterinary drug vendors. Communities also purchase these acaricides and misuse them which, contributed to the increase of acaricide resistance. This is a good indication for policy makers and local authorities to take strict action on illegal drug vendors.