TPS 791: Occupational health 1, Exhibition Hall, Ground floor, August 26, 2019, 3:00 PM - 4:30 PM Several pesticides have been associated with malignant and non-malignant renal disease in the Agricultural Health Study (AHS), a prospective cohort of pesticide applicators; however, it remains unclear whether individual pesticides contribute to early stage alterations in kidney function. To address this gap, we investigated the relationships between lifetime use of 48 pesticides and kidney function utilizing sera collected from 1,545 participants (including 1,302 currently farming/applying pesticides) in the Biomarkers of Exposure and Effect in Agriculture (BEEA) study, a subcohort within the AHS. Estimated glomerular filtration rate (eGFR) was calculated based on serum creatinine measurements using the CKD-EPI equation. The associations between individual pesticides and ln-transformed eGFR were estimated using multivariate linear regression models, and logistic regression models were used to estimate odds ratios (95% confidence intervals) for diminished kidney function (eGFR <60 vs. ≥60 mL/min/1.732). All analyses were adjusted for age, state of residence, body mass index, diabetes, hypertension, cigarette smoking, alcohol consumption, and correlated pesticides. Compared with never users, we observed lower eGFR among those who used the herbicides pendimethalin (-3.6%, 95% CI=-5.7,-1.5), atrazine (-3.6%, 95% CI=-6.7,-0.3), and dicamba (-3.4%, 95% CI=-6.0,-0.8). 2,4,5-T use was also associated with lower eGFR (-3.1%, 95% CI=-5.9,-0.2) in analyses restricted to current farmers/pesticide applicators. Some pesticides were unexpectedly associated with higher eGFR in the overall study population (e.g. malathion, methyl bromide, ethylene dibromide). An increased risk of diminished kidney function was also observed among pendimethalin users in overall analyses (OR 1.6, 95% CI 1.1,2.2), and among current farmers/pesticide applicators who used atrazine (OR 2.3, 95% CI 1.1,4.8); these herbicides were previously associated with end-stage renal disease in the AHS. Our results suggest that use of certain herbicides may be related to impaired kidney function; additional studies are needed to elucidate the mechanisms through which these chemicals may influence the development of renal disease.