The quality of newborns’ health, especially premature babies has the particular importance in the context of declining fertility. Retinopathy of prematurity (ROP) is a severe vasoproliferative disease affecting the immature vascular system of the retina in premature infants. This is one of the main reasons leading to irreversible vision loss in young children now. Since 2012, based on the State budgetary institution of Rostov region “Regional children’s clinical hospital” organized active screening, diagnosis and treatment of ROP. Since 2016, based on this institution, as well as the Perinatal center of the Rostov region, measures for the prevention of retinopathy of prematurity using red protective filter glasses have been applied. In 2016, the effectiveness of surgical laser treatment was 89 %, due to the increased number of children with aggressive posterior ROP and lightning-fast course of the disease and the lack of preventive measures in most departments of nursing premature babies. In 2017, the effectiveness of surgical laser treatment was 88 %, the relative decrease was due to an increase in the threshold stages. In 2018, the operational effectiveness of laser treatment was 93 %, because of the timely surgical treatment, to improve the quality of nursing preterm infants, active application of measures of prevention with the use of red filter protective in many branches the care of premature infants. The use of red filter protective glasses is a simple and affordable method of preventing retinopathy of prematurity, which reduces the need for surgical laser treatment and the number of adverse outcomes of the disease.