Aggregated Form Research Articles

Impact of socioeconomic prosperity and race on crowdfunding success

PurposePrior research treated entrepreneurs’ actions as purely opportunistic and voluntary, excluding social and economic systems’ influence on entrepreneurial actions. However, the applications of communication strategies, project management and social network are anchored in socioeconomic systems in which the entrepreneurs are rooted. To address the gap, this study aims to articulate – through the prism of institutional theory – how restaurant crowdfunding (CF) success is affected by socioeconomic prosperity according to entrepreneurs’ race and geographic area.Design/methodology/approachThe current study analyzed 2,008 restaurant CF projects launched in the USA through the Kickstarter platform from 2010 to 2020. By conducting one-way analysis of variance and multilevel mixed-effect logistic regression models, this study examined the relative socioeconomic prosperity and CF success according to the race of the restaurant entrepreneurs. The study also examined how socioeconomic prosperity affected CF success and how that relationship was moderated by the entrepreneurs’ level of restaurant experience.FindingsThis study finds that relative socioeconomic prosperity and CF success does differ according to race. Also in the CF context, lower socioeconomic prosperity does impede fundraising success. While the level of restaurant experience significantly increased an entrepreneur’s CF success, the impact was not so significant as to overcome the impact of socioeconomic prosperity.Research limitations/implicationsDrawing on institutional theory, this study examines the impact of socioeconomic prosperity on CF project outcomes. By uncovering the significant impact of socioeconomic systems on CF success, this study fills the research gap. Previous studies have generally treated minority entrepreneurs as an aggregated form. The authors’ results extend the literature by including major ethnic groups – whites, African Americans and Asians.Practical implicationsThe findings of the current study show restaurant entrepreneurs can raise the likelihood of CF success by doing two things: first, accumulate experience in the restaurant industry; second, use their CF websites to highlight testimonials about the value of that experience. Federal, state and local governments can institute policies to help improve racial minorities’ socioeconomic conditions and thereby promote startups’ fundraising success.Originality/valueTo the best of the authors’ knowledge, this study is one of the first to examine unexplored institutional effect on CF outcomes. It examines how and why socioeconomic factors affect minority entrepreneurs’ funding success. It compares the prosperity and CF success of white, African American and Asian entrepreneurs.

The limits of conformity analysis under the Newcomb-Benford law and the COVID-19 pandemic in Brazil

This research investigated the possible divergences in results due to the use of the Newcomb-Benford Law to assess the conformity of information regarding infections and deaths caused by the SARS-CoV-2 coronavirus, from transversal clippings made two years after the arrival of the COVID-19 pandemic in Brazil, through the comparative analysis of the results of statistics related to the Z test, the Chi-square test (X2), the Kolmogorov-Smirnov test (KS), and also the mean absolute deviation (MAD). For this, two distinct samples were analyzed: one referring to data accumulated over two years of the pandemic in Brazil, from 02/25/2020 to 02/25/2022; and another exclusively to data from the day the pandemic was completed two years of its arrival in Brazil, therefore exclusively on 02/25/2022. Thus, it was possible to observe that the Brazilian epidemiological information system, governed by the health policies adopted by the Government, did not function properly during the COVID-19 pandemic, and still, there was no improvement in quality, even after two years of the pandemic. Additionally, evidence was observed that the data series relating to the contaminations and deaths caused by the SARS-CoV-2 coronavirus present behavior distinct from the expected frequency distributions according to the Newcomb-Benford Law, either as a result of a natural process or due to particular issues of the Brazilian information system itself, for example, logistics, data distortions, forms of geographic aggregation, errors and/or negligence, among other factors.

Influence of pyrophosphate (PPi) and adenosine 5`-triphosphate (ATP) on the conformational stability and ultrastructure of silver carp myofibrillar proteins at low salinity

The effect of pyrophosphate (PPi) in comparison with adenosine 5`-triphosphate (ATP) on the thermal and ultrastructural properties of silver carp myofibrillar protein (SMf) was studied. The temperatures for 50 % denaturation (T1/2) of PPi-treated myosin and actin were 38 °C and 41 °C, respectively, lower than those for control SMf (43 °C and 48 °C, respectively). In comparison, T1/2 of myosin in ATP-treated SMf was 42 °C, while T1/2 of actin cannot be detected because no changes in actin digestion pattern. The ultrastructural change of PPi-treated and control SMf differed considerably from that of ATP-treated SMf in which the typical striated structural pattern disappeared, replaced by an aggregated form. In contrast, PPi-treated SMf retained the striated structure with lengthened sarcomere. Therefore, while both PPi and ATP can dissociate actomyosin, the presence of ATP hinders the chymotryptic digestion of actin.

Alpha synuclein modulates mitochondrial Ca2+ uptake from ER during cell stimulation and under stress conditions

Alpha synuclein (a-syn) is an intrinsically disordered protein prevalent in neurons, and aggregated forms are associated with synucleinopathies including Parkinson’s disease (PD). Despite the biomedical importance and extensive studies, the physiological role of a-syn and its participation in etiology of PD remain uncertain. We showed previously in model RBL cells that a-syn colocalizes with mitochondrial membranes, depending on formation of N-terminal helices and increasing with mitochondrial stress1. We have now characterized this colocalization and functional correlates in RBL, HEK293, and N2a cells. We find that expression of a-syn enhances stimulated mitochondrial uptake of Ca2+ from the ER, depending on formation of its N-terminal helices but not on its disordered C-terminal tail. Our results are consistent with a-syn acting as a tether between mitochondria and ER, and we show increased contacts between these two organelles using structured illumination microscopy. We tested mitochondrial stress caused by toxins related to PD, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP/MPP+) and carbonyl cyanide m-chlorophenyl hydrazone (CCCP) and found that a-syn prevents recovery of stimulated mitochondrial Ca2+ uptake. The C-terminal tail, and not N-terminal helices, is involved in this inhibitory activity, which is abrogated when phosphorylation site serine-129 is mutated (S129A). Correspondingly, we find that MPTP/MPP+ and CCCP stress is accompanied by both phosphorylation (pS129) and aggregation of a-syn. Overall, our results indicate that a-syn can participate as a tethering protein to modulate Ca2+ flux between ER and mitochondria, with potential physiological significance. A-syn can also prevent cellular recovery from toxin-induced mitochondrial dysfunction, which may represent a pathological role of a-syn in the etiology of PD.

Spatial distribution of vertical carbon fluxes on the Agulhas Bank and its possible implication for the benthic nepheloid layer

Vertical particle fluxes of particulate organic carbon (POC), chlorophyll a (Chl a) and biogenic silica (bSi) were measured on the productive shelf of southern Africa, the Agulhas Bank (AB), in March 2019. Sinking particulate material in the form of aggregates is hypothesized to form the benthic nepheloid layer (BNL) which is a turbid layer found near the seabed. This layer is known to affect the spawning success of squid as it is linked to high turbidity which reduces visibility during mating. To determine the distribution of fluxes and particle composition in the AB, we collected water samples below the surface mixed layer (‘export’) and near the seabed (‘bottom’) using a Marine Snow Catcher. POC export fluxes were significantly higher inshore than offshore (mean ± SD: 944.6 ± 302.0 & 461.1 ± 162.1 mg POC m−2 d−1, respectively). There was no significant difference in the cross-shelf distribution of Chl a and bSi export fluxes, however the inshore fluxes of Chl a and bSi were higher than offshore, suggesting a link between export fluxes and sinking organic matter derived from the more productive inshore surface waters. All bottom fluxes were significantly higher inshore, suggesting the contribution of sinking organic particles and resuspended bottom sediments to inshore fluxes. POC export efficiency (ratio of exported POC flux relative to net primary production (NPP)) was higher on the AB (range: 0.58–9.56) compared to the global shelf seas ratio of 0.18 and not related to NPP, suggesting an export of standing stock of carbon biomass, likely produced before the cruise. Transfer efficiency (i.e., the amount of exported flux that reaches the bottom) was also high (max: 0.99, 1.0 and 33.04 for POC, Chl a and bSi, respectively) but did not show a clear spatial pattern. We observed a significant positive correlation between bottom turbidity (a proxy for BNL presence) and export POC flux, suggesting the possibility that sinking organic matter is contributing to BNL formation on the AB.

The C-terminus of α-Synuclein regulates its dynamic cellular internalization by Neurexin 1β.

The aggregation of the disordered neuronal protein, α-Synuclein (αS), is the primary pathological feature of Parkinson's disease. Current hypotheses favor cell-to-cell spread of αS species as underlying disease progression, driving interest in identifying the molecular species and cellular processes involved in cellular internalization of αS. Prior work from our lab identified the chemically specific interaction between αS and the pre-synaptic adhesion protein neurexin 1β (N1β) to be capable of driving cellular internalization of both monomer and aggregated forms of αS. Here we explore the physical basis of N1β-driven internalization of αS. Specifically, we show that spontaneous internalization of αS by SH-SY5Y and HEK293 cells expressing N1β requires essentially all of the membrane-binding domain of αS; αS constructs truncated beyond residue 90 bind to N1β in the plasma membrane of HEK cells, but are not internalized. Interestingly, prior to internalization, αS and N1β co-diffuse rapidly in the plasma membrane. αS constructs that are not internalized show very slow mobility themselves, as well as slow N1β diffusion. Finally, we find that truncated αS is capable of blocking internalization of full-length αS. Our results draw attention to the potential therapeutic value of blocking αS-N1β interactions.

Phthalocyanine aggregates in the photodynamic therapy: dogmas, controversies, and future prospects.

Photodynamic therapy (PDT), a rapidly developing method for the treatment of cancer and bacterial diseases, is based on the photosensitization of oxygen to generate reactive oxygen species (ROS) that destroy specific biological targets. Among the various photosensitizers, phthalocyanines (Pc) have attracted particular attention due to their excellent photophysical properties, most of which meet the therapeutic requirements. The statement that aggregation of Pc-based photosensitizers is undesirable because it suppresses ROS generation has become commonplace in PDT. In this review, we have collected and discussed a number of works whose results refute this well-established axiom and show that aggregated forms of phthalocyanines can still exhibit photodynamic activity, in some cases in synergy with the photothermal and optoacoustic effects. In addition, ROS generation can be induced by aggregates under the conditions of sonodynamic therapy.

Effective transport of aggregated hypericin encapsulated in SBA-15 nanoporous silica particles for photodynamic therapy of cancer cells

Photodynamic therapy (PDT) represents an interesting modality for the elimination of damaged biomaterials and cells. This treatment takes advantage of the photosensitizing properties of molecules that are active only when irradiated with light. In the present work, a dual property of hypericin, a hydrophobic molecule with high performance in photodiagnostics and photodynamic therapy, was exploited. The non-fluorescent and photodynamically inactive form of hypericin aggregates was loaded into the nanopores of SBA-15 silica particles. The synthesized particles were characterized by infrared spectroscopy, thermogravimetry, differential thermal analysis, small-angle X-ray scattering and transmission electron microscopy. Hypericin aggregates were confirmed by absorption spectra typical of aggregated hypericin and by its short fluorescence lifetime. Release of hypericin from the particles was observed toward serum proteins, mimicking physiological conditions. Temperature- and time-dependent uptake of hypericin by cancer cells showed gradual release of hypericin from the particles and active cellular transport by endocytosis. A closer examination of SBA-15-hypericin uptake by fluorescence lifetime imaging showed that aggregated hypericin molecules, characterized by a short fluorescence lifetime (∼4 ns), were still present in the SBA-15 particles upon uptake by cells. However, monomerization of hypericin in cancer cells was observed by extending the hypericin fluorescence lifetime by ∼8 ns, preferentially in lipid compartments and the plasma membrane. This suggests a promising prognosis for delayed biological activity of the entire cargo, which was confirmed by effective PDT in vitro. In summary, this work presents an approach for safe, inactive delivery of hypericin that is activated at the target site in cells and tissues.

The intracerebral injection of Aβ1-42 oligomers does not invariably alter seizure susceptibility in mice.

Epileptiform activity and seizures are present in patients with Alzheimer's disease (AD) and genetic animal models of AD. Amyloid beta 1-42 (Aβ1-42) oligomers are thought to be crucial in AD and can cause neuronal hyperexcitability in vitro. However, it is unclear whether these Aβ1-42 oligomers cause the increased seizure susceptibility in vivo in people with AD and in AD animal models, nor via which mechanisms it would do so. We investigated this question by injecting Aβ1-42 oligomers intracerebrally in mice and assessed its impact on seizure susceptibility. We performed a single intracerebral injection of synthetic Aβ1-42 oligomers or scrambled Aβ1-42 in NMRI mice in three different cohorts and subjected them to an i.v. infusion of a chemoconvulsant. We evoked the seizures 1.5 h, 1 week, or 3 weeks after the intracerebral injection of Aβ1-42 oligomers, covering also the timepoints and injection locations that were used by others in similar experimental set-ups. With a thioflavine T assay and transmission electron microscopy we confirmed that Aβ1-42 monomers spontaneously aggregated to oligomers. We did not find an effect of Aβ1-42 oligomers on susceptibility to seizures - evoked 1.5 h, 1 week or 3 weeks - after their intracerebral injection. The lack of effect of Aβ1-42 oligomers on seizure susceptibility in our experiments contrasts with recent findings in similar experimental set-ups. Contradicting conclusions are frequent in experiments with Aβ1-42 and they are often attributed to subtle differences in the various aggregation forms of the Aβ1-42 used in different experiments. We confirmed the presence of Aβ1-42 oligomers with state-of-the-art methods but cannot ascertain that the protein aggregates we used are identical to those used by others. Whether our findings or those previously published best represent the role of Aβ1-42 oligomers on seizures in AD remains unclear.

Ecological mechanisms of biofilm development in the hybrid sludge-biofilm process: Implications for process start-up and optimization

The hybrid sludge-biofilm processes have been widely applied for the construction or upgradation of biological wastewater treatment process. Ecological mechanisms of biofilm development remain unclear in the hybrid ecosystem, because of the intricate interactive effects between sludge and biofilms. Herein, the establishment principles of biofilms with distinct coexisting sludge amounts were uncovered by varying sludge retention times (SRTs) from 5 to 40 days in the hybrid process. With the increasing of SRTs, biofilm biomass decreased with the increase of suspended sludge, resulting in lower biofilm proportion. As estimated by the Gompertz growth model, the increased sludge amounts (i.e., higher SRTs of 20 and 40 days) prolonged the initial colonization stage and decreased the specific development rate of biofilms when compared to lower sludge amounts with the shorter SRTs (i.e., 5 and 10 days). Null model analysis demonstrated that deterministic homogenous selection could facilitate the colonization and accumulation of biofilms with less coexisting sludge (SRT of 10 days). However, stochastic ecological drift and homogenizing dispersal dominated the colonization and accumulation stages of biofilms with more coexisting sludge (SRT of 20 days), respectively. The ecological networks reflected that positively-related taxa presented taxonomic relatedness, whereas high inconsistency of taxonomic relatedness was observed among aggregate forms or development stages as affected by varied SRTs. The high incidence of intra-taxa co-occurrence patterns suggested that taxa with similar ecological niches could be specifically selected in biofilms when being exposed with less coexisting sludge. This study uncovered ecological mechanisms of biofilm development driven by varying the SRTs of suspended sludge, which would help to propose appropriate strategies for the efficient start-up and optimization of the hybrid sludge-biofilm system.

Interactions of REF1 and SRPP1 rubber particle proteins from Hevea brasiliensis with synthetic phospholipids: Effect of charge and size of lipid headgroup

According to the fatty acid and headgroup compositions of the phospholipids (PL) from Hevea brasiliensis latex, three synthetic PL were selected (i.e. POPA: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphate POPC: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine and POPG: 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol) to investigate the effect of PL headgroup on the interactions with two major proteins of Hevea latex, i.e. Rubber Elongation Factor (REF1) and Small Rubber Particle Protein (SRPP1). Protein/lipid interactions were screened using two models (lipid vesicles in solution or lipid monolayers at air/liquid interface). Calcein leakage, surface pressure, ellipsometry, microscopy and spectroscopy revealed that both REF1 and SRPP1 displayed stronger interactions with anionic POPA and POPG, as compared to zwitterionic POPC. A particular behavior of REF1 was observed when interacting with POPA monolayers (i.e. aggregation + modification of secondary structure from α-helices to β-sheets, characteristic of its amyloid aggregated form), which might be involved in the irreversible coagulation mechanism of Hevea rubber particles.

Mechanism research on the application of liquid film microencapsulation technology based on natural lotion in strengthening recycled bio‐composite wallpaper material

AbstractLow‐carbon technology is currently one of the main research directions in sustainable research. The purpose of this research is to explore environmentally friendly low‐carbon technologies to apply NL and wastes to the development of bio‐composite. This research can not only inhibit the release of toxic atmosphere from composite wallpaper materials but also propose new perspective for recycling several bulk wastes such as agricultural waste, waste plastics, and waste cooking oil. This study not only conducted an exploratory research on the degree of filling load from a vertical perspective but also conducted comparative experiments to clarify the strengthening effect of NL in a horizontal perspective. Several valuable findings are obtained through the analysis of several measurements such as mechanical performance and scanning electron microscope (SEM) morphology. The heat transfer effect between components inside the bio‐composite is enhanced by the action of NL. A better heat transfer effect can prevent heat from accumulating in local areas of bio‐composite, resulting in an increase in the overall initial pyrolysis temperature of thermogravimetric analysis (TGA) curve. It is found through experiments that when the biomass filler is excessive, the mechanical performance of the sample sharply decreased. These negative phenomena are presented in the specific form of voids and aggregates in the internal structure of bio‐composite from a microscopic perspective. Comprehensive analysis manifested that NL can suppress the negative effect of filler agglomeration and strengthen the filler/matrix interface bonding. The research also found that the type of biomass filler can affect the actual effect of NL. These findings have certain academic significance and can promote the further development of sustainable research on diversified recycle of wastes.

Research on Spatial–Temporal Characteristics and Driving Factors of Urban Development Intensity for Pearl River Delta Region Based on Geodetector

The Pearl River Delta (PRD) is one of the most dynamic economic regions in the Asia-Pacific region. At present, it still faces many problems, such as the over-exploitation of urban land and unbalanced development. Through the study of the spatial–temporal characteristics of the development intensity of the PRD region and its driving factors, the key points and difficulties of urban development can be intuitively found. In previous studies, geodetector was widely used to determine the impact of driving factors. This paper uses several different research methods, including the Moran index, the semi-variability index, hot and cold spots, etc., based on the land use data of the PRD region in 1990, 2000, 2010, and 2020 to analyze the spatial–temporal characteristics of the development intensity. Combined with the socio-economic data of the statistical yearbook, factor detection and interaction detection of the 10 driving factors of development intensity are carried out based on geodetector, and reasonable optimization suggestions are put forward for the current situation of the region. The main conclusions are as follows: (1) The overall development intensity of the PRD region shows an upward trend, showing a “core periphery” spatial pattern of high center and low periphery centered around the Pearl River estuary. (2) The spatial distribution of cold and hot spots shows agglomeration, mainly in the form of high aggregation and low aggregation. (3) The driving factors for the development intensity for the PRD region in the past 30 years mainly include population agglomeration level, industrial structure level, economic strength level, terrain slope, etc. Among them, any two factors have a stronger interaction than a single factor, and all are enhanced by two factors. The dominant factors of interaction in different periods are different.

Recombinant protein based on domain III and capsid regions of zika virus induces humoral and cellular immune response in immunocompetent BALB/c mice

Zika virus infection continues to be a global concern for human health due to the high-risk association of the disease with neurological disorders and microcephaly in newborn. Nowadays, no vaccine or specific antiviral treatment is available, and the development of safe and effective vaccines is yet a challenge. In this study, we obtained a novel subunit vaccine that combines two regions of zika genome, domain III of the envelope and the capsid, in a chimeric protein in E. coli bacteria. The recombinant protein was characterized with polyclonal anti-ZIKV and anti-DENV antibodies that corroborate the specificity of the molecule. In addition, the PBMC from zika-immune donors stimulated with the ZEC recombinant antigen showed the capacity to recall the memory T cell response previously generated by the natural infection. The chimeric protein ZEC was able to self-assemble after combination with an immunomodulatory specific oligonucleotide to form aggregates. The inoculation of BALB/c mice with ZEC aggregated and not aggregated form of the protein showed a similar humoral immune response, although the aggregated variant induced more cell-mediated immunity evaluated by in vitro IFNγ secretion. In this study, we propose a novel vaccine candidate against the zika disease based on a recombinant protein that can stimulate both arms of the immune system.

Legal framework for sustainable development and current global challenges

<p>The subject of the article is the formation of the legal framework for sustainable development in the context of modern global challenges. The subject of the legal framework is the social relations of sustainable development, which are regulated by separate branches of law, but in the aggregate form a separate branch of law. The legal foundations of sustainable development, formed under the influence of international cooperation processes, are currently exposed to new threats-illegitimate economic restrictions that call into question the previously stated goals of sustainable development. The purpose of the article is to review the current state and prospects for the development of the legal framework in the context of both traditional threats and new challenges caused by the external restrictions since 2014, and to assess the prospects for sustainable development in Russia. The main research method is the study of international and Russian scientific research literature, analytical and review materials from open sources using induction, deduction, analysis, synthesis and the method of analogies. In preparing the article, historical, statistical, system-structural and causal research methods were also used. It has been proved that the first year of the functioning of the national economy under the newly introduced sanctions in 2022 showed both their negative impact and a certain adaptive potential of the economic system and companies. The article is focused on the prerequisites for the formation, essence and subject of sustainable development law, as well as on methods of legal regulation and examples of legal mechanisms for incorporating sustainable development factors into business practices. The article raises the question of the legitimacy of unilateral economic sanctions from the point of view of international law. The article also assesses the impact of sanctions on the activities of companies and their commitment to the principles of sustainable development. The conclusion is made that business community considers the mechanisms of legal regulation of sustainable development as anti-crisis measures and considers those mechanisms to be expedient and justified in the long term to pursue a policy of maintaining a commitment to sustainable development and finding ways to overcome sanctions pressure.</p>

Mathematical modelling of waste flows and treatment based on reconstruction of historical data: Case of wastewater sludge in Czech Republic

The contribution of supporting tools developed for logistic optimization and processing infrastructure planning is highly dependent on the quality of input data. Databases containing reports on waste production and treatment are often used for waste management case studies and in the aggregated form at the national level provide sufficient information with negligible errors. On the other hand, analysis in greater detail at the smallest administrative unit usually reveals significant inconsistencies, especially in the case of mass balance control. This often results in the impossibility to track waste flows in the system and evaluate final treatment. This paper aims to present a tool for database verification in order to satisfy mass balances at all levels of the investigated system. As part of the mathematical modelling, the database is first subjected to a statistical analysis where selected inconsistencies between records can be removed. Subsequently, data reconciliation is applied with appropriate weights assigned to each entity in the system. The weights represent credibility and reflect various errors, which are identified in the previous stage of the approach. The correction of mass balances enables an evaluation of quality or composition in greater detail of individual entities and also determines the feasible interval of monitored properties. The tool is applied to the treatment evaluation of dry matter in wastewater sludge in the Czech Republic. Thanks to the developed tool, disposal and material or energy recovery can be quantified at micro-regional.

Input subsidies, public investments and agricultural productivity in India

The fund allocation in agricultural sector in India is heavily tilted toward input subsidies provision; however, researchers seem to favor investment expenditure instead. The present paper seeks to compare the usefulness of input subsidies as compared to investment with regard to agricultural productivity so that policy makers hit the right tool and avoid less productive state expenditure. We investigated a total of four regression models using autoregressive and distributed lag cointegration in a time series framework covering period from 1983 to 2019. The first model considers all input subsidies in aggregate form, and the rest three models take input subsidies in disaggregate forms, namely fertilizer subsidy, irrigation subsidy and power subsidy, respectively. It is observed from the results that input subsidies still contribute more than what public investment does to agricultural productivity. It is also found that power subsidy is the most effective component of input subsidies followed by fertilizer subsidy. Hence, government expenditure on input subsidies is justified on the ground that it ensures all farmers to have access to affordable agricultural inputs. Targeted subsidies combined with adequate investment in agricultural infrastructure could deliver long-term agricultural development in India.

Quantum-Chemical Study of Aggregation of 5-(4'-Dimethylaminobenzylidene)Barbituric Acid

Decreasing fluorescence efficiency in the solid-state is general and is mainly attributed to the intermolecular vibronic interactions, which induce the nonradiative deactivation process. Whereas the isolated dye molecules are virtually non-luminescent in dilute solutions, they become highly emissive upon solution thickening or aggregation in poor solvents or in the solid-state show an increase of luminescence intensity, the phenomenon of the aggregation-induced emission (AIE phenomenon). The development of efficient luminescent materials is a topic of great current interest. Theoretical calculation shows that the dye molecules' aggregation-induced emission characteristics result from intermolecular interactions. Utilizing such features, the molecules can be employed as fluorescent probes for the detection of the ethanol content in aqueous solutions. Quantum-chemical calculations using the method of density functional theory the computations of structure and electronic spectra of aggregated forms of 5-(4’-dimethylaminobenzylidene)barbituric acid and the Gaussian 98 program packages have been performed. The unusual spectral behavior of 5-(4’-dimethylamino-benzylidene)barbituric acid was investigated theoretically by the DFT method and its time-dependent variant TDDFT. Carried out calculations using Zindo, as well as ab initio calculations, confirm the appearance of a new band during aggregation and its shift to the red region when the number of molecules increases.

Acupuncture therapy for post-stroke depression: A scoping review of randomized controlled trials

The prevalence of post-stroke depression (PSD), a common complication following a stroke, is rising yearly. Due to the success in treating PSD, acupuncture therapy has gained in popularity in recent years. To provide clinicians with more referable recommendations, we undertook a scoping study to examine the clinical evidence and status of acupuncture for the treatment of PSD. This scoping review followed Arksey and O'Malley's framework. Six databases were systematically searched to identify randomized controlled trials (RCTs) published in English or Chinese language that evaluated any type of acupuncture, with or without co-interventions, for treating PSD. Data were analyzed using descriptive statistics and organized in response to review questions. Findings were presented in a visual and aggregate form as well as in a descriptive format aligning with the objectives and scope of this protocol. A total of 231 RCTs were included, of which 230 were conducted in China. The applied acupuncture-related therapies included manual acupuncture, electroacupuncture, head acupuncture, auricular acupuncture, abdominal acupuncture, press needle, pestle acupuncture, eye acupuncture, and wrist and ankle acupuncture. The most commonly used form of acupuncture was manual acupuncture (n=73, 31.60%), and DU20 (n=121, 52.38%) was the most frequently used acupuncture point. Only a small number of studies reported adverse events (n=30, 12.99%), with the main symptoms including subcutaneous bleeding, headache, and hematoma. Ninety-six of 149 studies reported an effectiveness rate of over 90%. A more standardized trial process is recommended to strengthen the clinical evidence and avoid irregularities in clinical trial methodology. Future studies should include populations from a wider range of countries to improve the generalisability of the evidence.

An archetype-based automated procedure to derive global-local seismic fragility of masonry building aggregates: META-FORMA-XL

The paper presents an automated procedure for deriving fragility curves for typological masonry aggregates, named META-FORMA-XL (MEchanical-Typological Approach FOR Masonry Aggregates – X Local). The topic deals with the urban-scale seismic vulnerability analysis, which can provide powerful information for developing risk mitigation plans and implementing strategies for reducing expected losses. However, when masonry buildings in aggregate are analysed, many issues arise, related to the lack of data, the complexity of the structural configurations and the presence of uncertainties. To this scope, the proposed procedure aims to investigate the seismic behaviour of masonry aggregates, based on numerical analyses carried out on ideal representations of the existing building stock, indicated as archetypes, by modelling geometrical and mechanical uncertainties characterizing buildings in the studied area. The archetype buildings are made according to exposure analyses by combining typical inventory collection forms and information derived from freely available databases. By investigating the seismic response of numerical models for a high number of archetype buildings, fragility curves are derived for all limit-states and two main directions, accounting for global and local damage mechanisms. The procedure is tested on low-rise row masonry aggregates in Southern Italy. The output of the procedure is validated on a real case study, for which a near-full information on the geometrical and mechanical features is available, providing a critical comparison in terms of fragility curves. Results highlight several advantages of the proposed approach, such as the possibility of identifying the most likely collapse mechanism for a specific masonry aggregation, the simplicity and the celerity of the analyses despite the large number of archetype models, and the exhaustive consideration of the uncertainties. Finally, the proposed concept can be readily extended to other aggregation forms and structural typologies.