Control Agency Research Articles

COVID-19 Vaccination and Ocular Adverse Events: A Self-Controlled Case Series Study From the Entire South Korean Population

This study aimed to assess the risk of ocular adverse events, including retinal artery occlusion (RAO), retinal vein occlusion (RVO), noninfectious uveitis (NIU), noninfectious scleritis (NIS), optic neuritis (ON), ischemic optic neuropathy (ION), and ocular motor cranial nerve palsy (OMCNP), following Coronavirus Disease 2019 (COVID-19) vaccination. Population-based self-controlled case series METHODS: This study utilized nationwide claims and vaccination data provided by the Korea National Health Insurance Service and Korea Disease Control and Prevention Agency. From the entire South Korean population of 52 million individuals, patients with incident RAO, RVO, anterior NIU, nonanterior NIU, NIS, ON, ION, or OMCNP between January 2021 and March 2022 were included. The postvaccination risk period was defined as up to 56 days after COVID-19 vaccination. The relative incidence rate ratios (IRRs) for RAO, RVO, anterior NIU, nonanterior NIU, NIS, ON, ION, and OMCNP during the risk periods were measured using conditional Poisson regression. The study included 6,590, 70,120, 137,958, 17,921, 15,492, 2,039, 49,089, and 11,312 cases of incident RAO, RVO, anterior NIU, nonanterior NIU, NIS, ON, ION, and OMCNP, respectively. The IRRs (95% confidence interval) during the early risk period (0-28 days) were 0.95 (0.88-1.01), 0.96 (0.94-0.98), 0.93 (0.91-0.94), 0.93 (0.89-0.96), 0.96 (0.92-1.01), 1.04 (0.92-1.18), 0.98 (0.95-1.00), and 0.91 (0.86-0.96), respectively. In the late risk period (29-56 days), the IRRs were 0.96 (0.89-1.03), 0.93 (0.91-0.96), 0.96 (0.95-0.98), 1.00 (0.95-1.04), 0.96 (0.91-1.01), 1.00 (0.87-1.15), 1.01 (0.98-1.04), and 0.95 (0.90-1.01), respectively. COVID-19 vaccination did not increase the risk of incident RAO, RVO, anterior NIU, nonanterior NIU, NIS, ON, ION, or OMCNP during the postvaccination period.

Universal health coverage saves more lives among severely ill COVID-19 patients: A difference-in-differences analysis of individual patient data in South Korea

BackgroundUniversal health coverage (UHC) ensures affordability of a variety of essential health services for the general population. Although UHC could mitigate the harmful effects of coronavirus disease 2019 (COVID-19) on patients and their socioeconomic position, the debate on UHC’s scope and ability to improve health outcomes is ongoing. This study aimed to identify the impact of UHC policy withdrawal on the health outcomes of South Korea’s severely ill COVID-19 patients.MethodsWe used a propensity score matching (PSM) and difference-in-differences combined model. This study’s subjects were 44,552 hospitalized COVID-19 patients contributing towards health insurance claims data, COVID-19 notifications and vaccination data extracted from the National Health Information Database and the Korea Disease Control and Prevention Agency from 1 December 2020 to 30 April 2022. After PSM, 2460 patients were included. This study’s exposures were severity of illness and UHC policy change. The primary outcome was the case fatality rate (CFR) for COVID-19, which was defined as death within 30 days of a COVID-19 diagnosis. There were four secondary outcomes, including time interval between diagnosis and hospitalization (days), length of stay (days), total medical expenses (USD) and the time interval between diagnosis and death (days).ResultsAfter the UHC policy’s withdrawal, the severely ill patients’ CFR increased to 284 per 1000 patients [95% confidence interval (CI) 229.1–338.4], hospitalization days decreased to 9.61 days (95% CI −11.20 to −8.03) and total medical expenses decreased to 5702.73 USD (95% CI −7128.41 to −4202.01) compared with those who were not severely ill.ConclusionsDuring the pandemic, UHC may have saved the lives of severely ill COVID-19 patients; therefore, expanding services and financial coverage could be a crucial strategy during public health crises.

First Nationwide Mpox Vaccination Program in the Republic of Korea: Implications for an Enhanced Public Health Response.

On May 1, 2024, the Republic of Korea lifted the infectious disease crisis alert for mpox, almost two years after the first case was reported. The Korea Disease Control and Prevention Agency (KDCA) has led the response, which included diagnosis, epidemiological investigations, treatment, and vaccination. This article particularly reviews the vaccination strategy implemented and proposes suggestions for enhancing future response efforts. Initially, the KDCA recommended pre-exposure prophylaxis for high-risk groups, later expanding to include broader demographics as domestic cases rose. By April 2024, a total of 6,863 individuals had received their first vaccine dose, with 3,875 completing the second dose of third-generation vaccines. Strategies to improve future responses include addressing stigma, securing nationally representative safety data, and conducting vaccine cost-benefit analyses. These measures will help ensure a robust and effective response to future outbreaks.

Evaluation of an influenza-like illness sentinel surveillance system in South Korea, 2017-2023

BackgroundGuided by the data from the surveillance system, public health efforts have contributed to reducing the burden of influenza in many countries. During the COVID-19 pandemic, many surveillance resources were directed at tracking the severe acute respiratory syndrome-Coronavirus 2. However, most countries have not reported surveillance evaluations during the COVID-19 pandemic. MethodsUsing the U.S. CDC surveillance evaluation method, we evaluated the influenza-like illness (ILI) sentinel surveillance performance in South Korea between January 2017 and September 2023. For the timeliness, we measured the mean time lag between the reports from the sentinel sites to the Korea Disease Control and Prevention Agency (KDCA) and surveillance result dissemination from KDCA. For the completeness, we measured the submission rate of complete reports per overall number of reports from each sentinel site to the KDCA. For the sensitivity, we calculated the correlation coefficient between the monthly number of ILI reports and the patients with ILI from the Korea national reimbursement data by either Pearson’s or Spearman’s test. For the representativeness, we compared the age-specific distribution of ILI between the surveillance data and the national reimbursement data using a chi-squared test. ResultsWe found that the surveillance performance of timeliness (less than 2 weeks) and completeness (97 %−98 %) was stable during the study period. However, we found a reduced surveillance sensitivity (correlation coefficient: 0.73 in 2020, and 0.84 in 2021) compared to that of 2017–2019 (0.96–0.99), and it recovered in 2022–2023 (0.93–0.97). We found no statistical difference across the proportion of age groups between the surveillance and reimbursement data during the study period (all P-values > 0.05). ConclusionsOngoing surveillance performance monitoring is necessary to maintain efficient policy decision-making for the control of the influenza epidemic. Additional research is needed to assess the overall influenza surveillance system including laboratory and hospital-based surveillance in the country.

Evaluation of the suitability of using ArtiSential in various renal surgery: IDEAL stage 1 study

BackgroundArtiSential, a new articulating laparoscopic instruments, addresses the limited movement associated with conventional laparoscopic instruments. This study was conducted to assess the clinical effectiveness of ArtiSential in detailed steps of various renal surgery.MethodsThis study was approved by the Institutional Review Board of our institution and registered on the Clinical Research Information Service site of the Korea Disease Control and Prevention Agency. Participants meeting all inclusion and exclusion criteria were included in the clinical trial and underwent renal surgery. The clinical effectiveness of ArtiSential was assessed in terms of the feasibility and objective and subjective parameters across 9 detailed steps.ResultsOf the 15 potential candidates enrolled from October 2021 to November 2021, 1 patient dropped out due to anaphylaxis from an anesthetic agent, and 14 patients underwent laparoscopic surgery using ArtiSential. Of the 14 patients, 2 patients were converted to laparoscopic surgery using straight-shaped instruments due to the ischemia time exceeding 30 min, and 1 patient due to excessive bleeding. The feasibility for most steps was more than 90%, except the renorrhaphy step. The median total operation time and ischemia time were 161 and 23 min, respectively. The median estimated blood loss was 58.5 mL. Two cases of venous injury occurred during renal pedicle dissection step. The accuracy of the procedure judged by reviewers and usability judged by the operator were acceptable in all steps. The surgeon’s quantitatively measured stress score was the highest during renorrhaphy step.ConclusionsLaparoscopic surgery using ArtiSential is feasible for most steps except the renorrhaphy step. The difficulty of performing renorrhaphy is attributed to prolonged ischemia time, which could be addressed by overcoming the learning curve.Trial registrationClinical Research Information Service site of the Korea Disease Control and Prevention Agency, KCT0006532. Registered 03/09/2021, https://cris.nih.go.kr/cris/search/detailSearch.do?seq=24071.

Impact of COVID-19 on human immunodeficiency virus tests, new diagnoses, and healthcare visits in the Republic of Korea: a retrospective study from 2016 to 2021.

Public health workers have been at the forefront of treating patients with coronavirus disease 2019 (COVID-19) and managing the pandemic. The redeployment of this workforce has limited or interrupted other public health services, including testing for human immunodeficiency virus (HIV). This study aims to examine the impact of COVID-19 on HIV testing and diagnosis in the Republic of Korea from 2016 to 2021, comparing data before and after the onset of COVID-19. Annual HIV testing data were collected from each institution through direct communication or from open-source databases. The annual number of new HIV cases was obtained from the official report of the Korea Disease Control and Prevention Agency. Data on healthcare visits for HIV diagnosis or treatment were extracted from the open-source database of the National Insurance Health Service of Korea. Interrupted time series regression was conducted, stratified by institution type. In 2020, HIV tests, diagnoses, and visits decreased. Notably, public health centers experienced a substantial reduction in 2020-2021 compared to previous years. The annual percentage change in HIV tests was -53.0%, while for HIV diagnoses, it was -31.6%. The decrease in visits for HIV was also most pronounced for public facilities: -33.3% in 2020 and -45.6% in 2021 relative to 2019. The numbers of tests, diagnoses, and healthcare visits for HIV at public health centers in the Republic of Korea substantially decreased in 2020 and 2021. The impacts of these changes on the early diagnosis and treatment of HIV necessitate further monitoring.

Evaluation of the acute hepatitis B surveillance system in the Republic of Korea following the transition to mandatory surveillance.

The prevalence of hepatitis B in the Republic of Korea has declined, yet the disease burden persists. After various changes in targets and methods, the national hepatitis B surveillance system now exclusively monitors acute cases. We aimed to assess the alignment of this system with its intended purpose and to recommend improvements supporting the national strategic plan for viral hepatitis management. This study assessed acute hepatitis B cases reported to the Korean Disease Control and Prevention Agency's mandatory surveillance system over a 10-year period (2013-2022). It evaluated 5 factors from the Centers for Disease Control and Prevention's Updated Guidelines for Evaluating Public Health Surveillance Systems: simplicity, positive predictive value, data quality, timeliness, and usefulness. The nonspecific nature of acute hepatitis B symptoms, along with the complexity of diagnostic criteria, indicated a high potential for misreporting. The surveillance system demonstrated a high positive predictive value (94.4%), with data quality and timeliness also rated high. However, data following the onset of the coronavirus disease 2019 pandemic indicate the need for improvement. Moreover, given the relative importance of specific characteristics of chronic infectious diseases, only limited interventions are implementable through the current surveillance system. The evaluation of the Republic of Korea's acute hepatitis B surveillance system revealed high positive predictive value, data quality, and timeliness. However, improvements can be made in the misreporting of chronic cases and the system's usefulness. More accurate reflection of the characteristics of acute hepatitis B cases is essential for better management of viral hepatitis.

Impact of Alcohol-Induced Facial Flushing Phenotype on Alcohol Consumption Among Korean Adults: 2-Year Cross-Sectional Study.

The alcohol-induced facial flushing phenotype (flushing) is common among East Asians. Despite a small intake of alcohol, they experience heightened levels of acetaldehyde, a group-1 carcinogen, which, in turn, causes unpleasant symptoms such as redness, acting as a robust protective mechanism against consuming alcohol. However, some individuals with this genetic trait exhibit weakened alcohol restraint, which increases the risk of developing alcohol-related cancers, such as esophageal and head or neck cancer, by several times. Although this flushing phenomenon is crucial for public health, there is a paucity of studies that have comprehensively investigated the effect of flushing or its genotype on alcohol consumption in a large group of East Asians while controlling for various sociodemographic and health-related variables at a country level. This 2-year cross-sectional study aims to explore the effect of flushing on drinking behavior in Koreans and to examine whether the effect varies across sociodemographic and health-related factors. We used data from the Korea National Health and Nutrition Examination Survey (KNHANES) for 2019 and 2020 conducted by the Korea Disease Control and Prevention Agency. Our sample comprised 10,660 Korean adults. The study investigated the association of 26 variables, including flushing, with drinking frequency and amount. The effect of flushing was examined with and without adjusting for the other 25 variables using multinomial logistic regression analysis. In addition, we tested the interaction effect with flushing and conducted a simple effect analysis. We used complex sample design elements, including strata, clusters, and weights, to obtain unbiased results for the Rao-Scott χ2 test, 2-tailed t test, and multinomial logistic regression analysis. The suppressive effect of flushing was significant (P<.001) across all pronounced categories of alcohol consumption in 2019. The ranges of standardized regression slopes and odds ratios (ORs) were -6.70≥β≥-11.25 and 0.78≥OR≥0.50 for frequency and -5.37≥β≥-17.64 and 0.73≥OR≥0.36 for amount, respectively. The effect became somewhat stronger when adjusted for confounders. The effect also exhibited an overall stronger trend as the severity of alcohol consumption increased. The β values and ORs were consistently smaller in 2020 compared to the previous year. A simple effect analysis revealed a diminished alcohol-suppressive effect of flushing on alcohol consumption for specific groups (eg, those with low levels of education, limited family support, physical labor, or health-related issues). Our findings suggest that flushing suppresses drinking in Koreans overall but has little or no effect in certain susceptible populations. Therefore, health authorities should conduct targeted epidemiological studies to assess drinking patterns and disease profiles, particularly regarding alcohol-related cancers, and establish effective preventive measures tailored to this population.

Physico-chemical and bacteriological quality assessment of some selected sachet water brands produced in Gwale local government Area, Kano Nigeria

The proliferation of sachet water products has been fuelled by the rising demand for clean, safe drinking water in areas where access to potable water sources remains a challenge. Unfortunately, some of the sachet water producers fail to adhere to the standards set by regulatory agencies, resulting in potential health risk for the unsuspecting consumers. Therefore, critical investigation of the various parameters of these water products is needed to determine whether they meet the safety standards established by regulatory agencies. Thirty (30) different brands of sachet water (15 NAFDAC registered and 15 non-NAFDAC registered) were randomly collected (n=3) from producers in Gwale Local Government Area, Kano Nigeria to assess their physico-chemical and bacteriological quality. The parameters were determined using standard methods. The mean results of the temperature, pH, turbidity, conductivity, chloride and total hardness of the NAFDAC registered samples were found to be in the range of 25.9-29.7 oC, 6.8-7.2, 0.1-1.2 NTU, 11.0-41.8µs/cm,15.0-25.1 mg/L and 2.0-17.6 mg/L respectively, while for the non-NAFDAC registered samples, the mean range were found to be 25.8-30.8 oC, 6.6-8.7, 0.5-2.2 NTU, 13.6-46.8 µs/cm, 17.0 23.0mg/L and 15.8-25.3 mg/L for the same parameters respectively. These results are in compliance with the standards set by the National Agency for Food Drug Administration and Control (NAFDAC), Nigerian Industrial Standard (NIS) and World Health Organization (WHO) except pH values of 8.7 found in some non-NAFDAC registered samples which were a bit higher than the recommended limits. Some non- NAFDAC registered samples were found to contain aerobic mesophilic bacteria, though below the limit set by the aforementioned regulatory agencies. Statistically, there is significant difference (p&gt;2.326) between the NAFDAC registered and the non-NAFDAC registered samples in aerobic mesophilic bacterial count but there is no significant difference in terms of coliform count between the two groups (p&lt; 2.326). This finding highlights the need for regular microbiological monitoring so as to ensure public health safety.

Changes in Smartphone Usage among Adolescents and Associated Subjective Health Concerns: A Secondary Analysis of the Korea Youth Risk Behavior Survey.

We evaluated changes in the smartphone use rate and time among Korean adolescents and their awareness of associated health problems. This study was a secondary analysis of the Korea Youth Risk Behavior Survey (2020-2023) conducted by the Korean Disease Control and Prevention Agency. The total number of enrolled adolescents aged 12-18 years was 214,526. The weekly smartphone usage rate increased from 96.4% to 97.1% (p = 0.03), with no significant changes observed in weekend usage. The average smartphone use time was 4.7 h on weekdays (p = 0.17) and 6.6 h on weekends (p = 0.37). Middle school adolescents had a higher weekday use rate than high school adolescents, but the average smartphone use time was significantly less. By 2023, the proportion of adolescents with overdependence was 28% (n = 14,672). Additionally, 11.8% (n = 6255) responded that they had experienced health problems due to smartphone use. The longer they used their smartphones for on the weekends, the more likely they considered their health to be worse. In conclusion, our youth population needs to be educated on the proper use of smartphones.

The Hand, Foot, and Mouth Disease Sentinel Surveillance System in South Korea: Retrospective Evaluation Study.

South Korea has implemented a hand, foot, and mouth disease (HFMD) surveillance system since 2009 to monitor incidence trends and identify disease burden. This nationwide surveillance involves a network of approximately 100 pediatric clinics that report all probable and confirmed HFMD cases. Following the COVID-19 pandemic, infectious disease surveillance systems must be evaluated to ensure the effective use of limited public health resources. This study aimed to evaluate the HFMD sentinel surveillance system in South Korea from 2017 to 2022, focusing on the transition period after the COVID-19 pandemic. We retrospectively reviewed the HFMD sentinel surveillance system from the Korea Disease Control and Prevention Agency using systematic guidelines for public health surveillance system evaluation developed by the US Centers for Disease Control and Prevention. We assessed the system's overall performance in 5 main factors: timeliness, stability, completeness, sensitivity, and representativeness (ie, the age and geographic distribution of sentinels). We rated these factors as weak, moderate, or good. Our study showed that the completeness, sensitivity, and age representativeness of the HFMD surveillance performance were temporarily reduced to moderate levels from 2020 to 2021 and recovered in 2022, while the timeliness and geographic representativeness were maintained at a good level throughout the study period. The stability of the surveillance was moderate from 2017 to 2021 and weak in 2022. This is the first study to evaluate the HFMD surveillance system after the acute phase of the COVID-19 pandemic. We identified a temporarily reduced level of performance (ie, completeness, sensitivity, and age-specific representativeness) during the acute phase of the pandemic and good performance in 2022. Surveillance system evaluation and maintenance during public health emergencies will provide robust and reliable data to support public health policy development. Regular staff training programs and reducing staff turnover will improve HFMD surveillance system stability.

Secure and Privacy-Protected Bioinformation Implementation in Air Passenger Transport Based on DLT

Aviation information systems are a key component in ensuring efficient and smooth air transport operations. In this regard, the transfer of passenger information between parties is of paramount importance. With the continuous improvement of biometrics technology, this kind of individual identification that can provide accurate and unforgeable identification is widely used in various fields. This research presents the significance and effective application scenarios of facial recognition in biometrics in air transport operations. Due to the characteristics of aviation information systems, Distributed Ledger Technology (DLT) is used in this study for secure and private transmission of facial recognition information. Distributed systems can give a transparent and secure platform to multiple parties to access sensitive passenger data. This study uses the Corda framework as the DLT that supports CorDapp development. Based on the above techniques, this study proposes two feasible application scenarios. One is a baggage match detection system to prevent misplaced baggage, and the other is an iAPIS system that transmits passenger information in real-time communication between airlines and border control agencies. This article details how to apply the research in these two scenarios, as well as the benefits and implications of the applications. Finally, this article presents an outlook for future development and feasible directions for improvement.

Identifying strategies to improve adverse drug reporting through key informant interviews among community pharmacists in a developing country

Reporting adverse drug reactions (ADRs) is fundamental in improving medication safety. Community pharmacists (CPs) being the first point of contact for individuals seeking healthcare in a community, play a significant role in ADR reporting. However, this has been poorly implemented in many countries including Nigeria. This paper aims to explore stakeholders’ perspectives on current reporting practices and suggest ways to enhance ADR reporting among CPs in Nigeria. This qualitative study employed a purposive sampling approach to identify key informants. Key informant interviews (KIIs) were conducted with 25 carefully selected pharmacists, using a semi-structured interview guide between July 2023 and August 2023. The interview transcripts were analyzed using a thematic content approach. While a low ADR reporting trend was observed among all participating pharmacists, it was notably higher among those with less than five years of experience. The main barriers to ADR reporting, as identified by the interviewed community pharmacists were lack of awareness and knowledge, absence of motivation, and insufficient feedback from National Agency for Food Drug Administration and Control (NAFDAC). Training and awareness campaigns were the most frequently suggested methods for improving ADR reporting. Other proposed strategies included providing motivation, regular feedback, establishing mandatory reporting, and simplifying the reporting process. The study has highlighted the suboptimal ADR reporting practices among CPs in Anambra state. It underscores the significance of training, sensitization, advocacy, and other related interventions as pivotal means to enhance ADR reporting in this group. Furthermore, there is a pressing need for intervention-based studies to delve into and implement these approaches effectively.

Physical activity and mental health trends in Korean adolescents: Analyzing the impact of the COVID-19 pandemic from 2018 to 2022.

Mental health significantly affects the physical and emotional development of adolescents. The aim of the current study was to examine how physical activity (PA) and mental health among Korean adolescents changed before and after the start of the COVID-19 pandemic. We used comparative cross-sectional methods, gathering information from the Korea Disease Control and Prevention Agency databases and conducting Chi-square testing and correlation analysis for evaluation. The findings indicate that before and during the pandemic, participation in both moderate- and high-intensity PA, as well as strength training, mitigated stress, depression, and suicidal ideation. Furthermore, the findings confirm the beneficial effects of various physical activities on mental well-being. These insights emphasize the vital role of regular PA in improving mental health among adolescents, particularly during a health crisis such as the pandemic.

Ground-Based Pyrethroid Adulticides Reduce Mosquitoes But Not Nontarget Insects in Central Florida.

As stewards of public and environmental health, mosquito control agencies are rightfully concerned about impacts on nontarget organisms. This study examined the impact of a modern, pyrethroid based ground adulticide program using ultra-low volume applications in a metropolitan county in central Florida. Nontarget insects and mosquitoes were collected in a before-after control-impact design at 21 sites over 1.5 years. While mosquitoes were reduced, we found no evidence for reduction of nontarget insects, regardless of taxon. Night-flying Lepidoptera may experience greater risk than other nontarget taxa, but overall effects of adulticide missions on this group were low and inconsistent. Instead, meteorology, habitat, and phenology dominate patterns of nontarget abundance. Mosquito reduction was more clearly observed and corrected post-mission reduction was consistent with results expected in complex urban and suburban treatment zones.

Barriers and facilitators to research data sharing: a lifecycle perspective

PurposeThis study investigates the multifaceted barriers and facilitators affecting research data sharing across the research data lifecycle. It aims to broaden the understanding of data sharing beyond the publication phase, emphasizing the continuous nature of data sharing from generation to reuse.Design/methodology/approachEmploying a mixed-methods approach, the study integrates the Theory of Planned Behavior, the Technology Acceptance Model, and the Institutional Theory to hypothesize the influence of various factors on data sharing behaviors across the lifecycle. A questionnaire survey and structural equation modeling are utilized to empirically test these hypotheses.FindingsThis study identifies critical factors influencing data sharing at different lifecycle stages, including perceived behavioral control, perceived effort, journal and funding agency pressures, subjective norms, perceived risks, resource availability, and perceived benefits. The findings highlight the complex interplay of these factors and their varying impacts at different stages of data sharing.Research limitations/implicationsThis study illuminates the dynamics of research data sharing, offering insights while recognizing its scope might not capture all disciplinary and cultural nuances. It highlights pathways for stakeholders to bolster data sharing, suggesting a collaborative push towards open science, reflecting on how strategic interventions can bridge existing gaps in practice.Practical implicationsThis study offers actionable recommendations for policymakers, journals, and institutions to foster a more conducive environment for data sharing, emphasizing the need for support mechanisms at various lifecycle stages.Originality/valueThis study contributes to the literature by offering a comprehensive model of the research data lifecycle, providing empirical evidence on the factors influencing data sharing across this continuum.

Research on Emotion Analysis Based on a Topic Emotion Fusion Model: The Case of the "Post-holiday Symptoms of Pharyngitis" Event on the Weibo Platform

[Objective] From early 2023 to 2024, multiple public health incidents related to "post-holiday pharyngitis" erupted in china, impacting public health and education among other areas. This study analyzes the data dissemination trends and the emotional development of these incidents. The insights are aimed at enhancing the government and disease control agencies' mechanisms for guiding and responding to such public sentiment incidents, thereby improving preparedness and response capabilities for potential future public health events. [Methods] The methodology employed involves using three instances of "post-holiday pharyngitis" events on the Weibo platform as data samples. The study applies the LDA model integrated with TD-IDF weighted Word2vec algorithm for thematic organization across different periods. The DUTIR sentiment dictionary is used to analyze public sentiment, and data visualization techniques are employed to present the thematic-emotional evolution within the incidents. [Results] The results suggest that the proposed thematic-emotional fusion model effectively extracts and analyzes the dissemination trends and emotional evolution of the event, providing actionable suggestions for government and public health agencies in managing such public sentiment incidents.

Beyond control? The political economy of private interception, intrusion, and surveillance markets

Private intrusion, interception, and surveillance (PIIS) markets represent a key vehicle for the global expansion of digital surveillance regimes. Yet, due to their opacity and notorious secrecy, these markets have received relatively little scholarly attention. Triangulating between a unique dataset comprising 5973 industry presentations, interviews, and industry reports, this article provides novel insights into the evolution of market structures and public control efforts. Conceptualizing the PIIS-market as a dynamic and fluid assemblage, we highlight how the enmeshment of social, political, and technological dimensions shaped hierarchies and agencies of control. Our findings point towards the existence of three intersecting dynamics of territorialization, changing technological affordances, and ordering that persistently undermined attempts to limit market operations. In reflecting on these past failures, the presented approach points towards the importance of timing and highlights a need to re-conceptualize control in state-market relations from an assemblage perspective, pragmatically working across bureaucratic boundaries and leveraging disparate power centers across the public and private divide. Considering the growing interest in economic dependencies and the strategic dimension of high-tech markets, these findings have a wider relevance to current debates about the rise of economic security states.

Making (in)formality work in a multi-scalar European border regime

ABSTRACT The European migration control regime claims to strife for ‘orderly’ and safe conditions of migration, yet systematically generates the opposite. This paper explores the role of informality in creating solutions to enable control and produce order in the European migration control regime by examining two areas of border policy characterised by high degrees of regulation and contestation : the implementation of the Dublin III Regulation (2013) and transnational negotiations over readmission agreements between European states and deportable people’s assumed countries of origin. We focus on Sweden and Switzerland, two countries perceived as having high degrees of ‘formality’ in their migration control regimes, and draw on ethnographic material generated between 2015 and 2018 in Swiss and Swedish migration control agencies. We demonstrate the central role of informality in making formal regulations 'work'. The Dublin Regulation necessitates tacit toleration of informality to be enforced, and readmission agreements rely on informal, transnational politics that neither follow migration law nor respectthe rights and lives of people on the move. The article underscores the importance of debunking the myth of an ‘orderly’ migration control regime, informality is what makes European migration control ‘work’, often to the detriment of people on the move.

Potentially inappropriate medication as a predictor of poor prognosis of COVID-19 in older adults: a South Korean nationwide cohort study

ObjectivesTo investigate the association between exposure to potentially inappropriate medication (PIM) and poor prognosis of COVID-19 in older adults, controlling for comorbidity and sociodemographic factors.Design and settingNationwide retrospective cohort study...