Aging Treatment Research Articles

Retrospective controlled study of the efficacy of very high molecular weight hyaluronic acid (VHMWHA) noncross-linked as a dermabooster for the improvement of elasticity in the skin.

Hyaluronic acid HA, regardless of its molecular weight, presentation and route of administration, is currently among the products most in-demand by our clients for the prevention and treatment of skin ageing in aesthetic medicine clinics.

Movement disorders related to antidiabetic medications: a real-world pharmacovigilance study

BackgroundDiabetic Mellitus (DM) has progressively emerged as a worldwide health problem, leading to the widespread deployment of antidiabetic drugs as the primary therapy in the global population. The incidence of diabetes medications-related movement disorders (drMD) is noteworthy but underestimated by clinical practitioners. Research design and MethodsIn order to address the incidence of drMD in DM patients and realize the serious outcomes associated with drMD, we conducted a real-world pharmacovigilance study of 612,043 DM patients using the FDA Adverse Event Reporting System (FAERS) database from January 2004 to September 2023. Reporting Odd Ratio (ROR) was calculated to reflect the risk of drMD. A multivariable logistic regression analysis was employed to adjust crude ROR with the mixed factors including age, sex and various antidiabetic treatments. Afterward, a Mendelian Randomization (MR) study was performed to elucidate the underlying genetic correlation between the genetically proxied targets of antidiabetic drugs and motor disorders. ResultsAmong 11,729 cases of motor adverse events in DM patients, six categories of drMD were significantly associated with DM medications. Noticeably, metformin was revealed to drastically increase the incidence of parkinsonism (adjusted ROR:3.97; 95 %CI (3.03, 5.19), p = 5.68e-24), bradykinesia (adjusted ROR:1.69; 95 %CI (1.07,2.59), p = 0.02) and irregular hyperkinesia, including chorea, choreoathetosis and athetosis. Insulin/insulin analogues and GLP-1 analogues presented notably higher odds of tremor: the adjusted ROR (aROR) of insulin and GLP-1 analogue is respectively 1.24 (95 %CI (1.15,1.34), p = 2.51e-08) and 1.78 (95 %CI (1.65,1.91), p = 5.64e-54). The combined therapeutic effects of multiple genetic variants of metformin, especially AMP-activated protein kinase (AMPK) were markedly linked to a greater likelihood of developing secondary parkinsonism (OR:10.816, p = 0.049) according to MR analyses. ConclusionThe use of antidiabetic medications was significantly related to an increased incidence of movement disorders in DM patients. Moreover, MR analyses provided further genetic evidence for the pharmacovigilance study. This comprehensive investigation might help physicians recognize neurological adverse events associated with antidiabetic treatments and administer effective interventions.

Electrical breakdown mechanism and life prediction of thermal-aged epoxy/glass fibre composites

Epoxy/glass fibre composites possess excellent mechanical and electrical properties and are widely utilised in electrical and electronic power equipment. However, the composites exhibit relatively poor thermal conductivity, causing the temperature of the composites to increase during the operation of power equipment, resulting in a significant reduction in the electrical breakdown strength. Although the effects of thermal aging on polymeric materials have been widely studied, its influence on electrical strength mechanisms has not been investigated at the molecular level. In this study, epoxy/glass fibre composite specimens were subjected to accelerated thermal aging treatment for 360 h at 180 °C. Functional groups, molecular chain dynamics, and electrical breakdown are characterised using infrared spectroscopy, dielectric spectroscopy, and breakdown measurement. Subsequently, electrical breakdown mechanism and life prediction of the thermally aged composites are discussed. During thermal aging, the epoxy resin molecular chains undergo continuous oxidation and chain scission, which generate numerous polar functional groups and short chains and an increase in the free volume. This triggers an enhancement in the chain segmental dynamics, thereby significantly reducing the activation energy of the epoxy resin. After 360 h, activation energy decreased from 0.78 eV to 0.67 eV. The DC breakdown voltages of the specimens decreased from 168.28 kV/mm to 134.91 kV/mm. An insulation life prediction model for thermally aged epoxy/glass fibre composites is established based on the time-temperature equivalence theory. The prediction results indicate that the service life of the operational composites is approximately 11.2 years at 353 K, which is consistent with engineering experience.

Effects of microstructures and double aging on high temperature yield strength in Ni–Co-base superalloy produced by a powder metallurgy route

Microstructural features and their effects on yield strength at high temperatures in the P/M HGN200 Ni–Co-base polycrystalline superalloy, subjected to a standard double aging treatment, have been clarified using both Thermo-Calc® and a unified approach. The matrix γ possesses a very fine grain size due to the used processes and pinning by primary γ'. The calculated antiphase boundary energy is very high, resulting in high yield strength. Dispersion of fine tertiary γ′ phases is remarkable to increase the yield strength compared with those of primary and secondary γ′; the contribution of the primary γ′ to the yield strength is negligible. The stoichiometric composition of primary and secondary γ′ is (Ni,Co)3(Ti,Al) and that of tertiary γ′ is (Ni,Co,Cr)3(Ti,Al) and the excellent high temperature strengthening is related to homogeneous dispersion of both the secondary and tertiary γ′.

Regulating the microstructures and creep behaviors of an LPSO-containing Mg alloy via heat treatment

The microstructures and creep behaviors of a hot-extruded Mg-Gd-Y-Zn-Zr alloy containing long period stacking order (LPSO) phases prepared by different heat treatment procedures were investigated in this work. Three samples were made, including Sample #1, which was in the as-extruded state; Sample #2, which was preserved at 500 °C for 12 h; and Sample #3, which was preserved at 500 °C for 12 h and 460 °C for 10 h. The average grain sizes of the heat treated samples were much larger than those of the as-extruded samples. The second phases included mainly blocky 18R LPSO phases, lamellar 14H LPSO phases and needlelike ZnZr compounds in the three samples, but Sample #2 had much fewer 14H LPSO phases than the other two samples. The grain boundary migration resulting from the small grain size induced the lowest creep resistance in Sample #1. In contrast, the hardening effects generated from the pyramidal <c+a> dislocations and the dynamic precipitation of dense β’ phases dramatically retarded the cross-slip, resulting in the highest creep resistance in Sample #2. Although the aging treatment introduced numerous 14H LPSO phases in Sample #3, they delayed the dislocation movements to a limited degree, and the creep resistance was inferior to that of Sample #2. Therefore, the creep resistance ultimately decreased in the order of Sample #2 > Sample #3 > Sample #1. It is suggested that the microstructures and creep behaviors of LPSO-containing Mg alloys can be well regulated through appropriate heat treatment, and this work can hopefully offer important guidance for the design of highly creep resistant Mg-Gd-Y-Zn-Zr alloys.

How to Distinguish Nonexponentiality and Nonlinearity in Isothermal Structural Relaxation of Glass-Forming Materials.

The nonexponentiality and nonlinearity are two essential features of the structural relaxation in any glass-forming material, which seem to be inextricably bound together by the material time. It is shown that the temperature down-jump and up-jump experiments of the same magnitude ΔT = T0 - T to the same temperature T provide a clue for their separation. The isothermal structural relaxation can be quantified using the stabilization period on the logarithmic time scale log(tm/t0). It is described as the sum of the nonexponentiality term 1.181/ß and the nonlinearity term (σ/2.303)ΔT for the temperature down-jump, and as their difference for the temperature up-jump. The material parameter σ = -(∂lnτ/∂Tf)i quantifies variation of the relaxation time with structural changes at the inflection point of the relaxation curve and is formulated for the most widely used phenomenological models. The asymmetry of approach to equilibrium after the temperature down-jump and up-jump was first described by Kovacs in 1963. A detailed analysis of this asymmetry is provided, and a simple method for the estimation of the parameters characterizing the nonexponentiality (ß) and nonlinearity (σ) is proposed. The applicability of this method is tested using previously reported isothermal experimental data as well as calculated data for aging of polymers and other glass-forming materials. This concept illuminates differences in structural relaxation kinetics in a simple and consistent way that can be useful in the design of novel materials and the evaluation of their physical aging treatment.

Tailoring size and fraction of coherent L12 nanoprecipitates to achieve strong hardening in medium entropy alloys with heterogeneous grain structures

Heterogeneous grain structures with coherent L12 nanoprecipitates were constructed in a medium entropy alloy with chemical composition of Co34.5Cr32Ni27.5Al3Ti3 (at. %). The volume fraction and size of L12 nanoprecipitates are observed to become higher and larger, and the interspacing is found to become smaller with increasing aging time, resulting in a severer heterogeneity. The domain of tensile properties was expanded by varying the size and volume fraction of coherent L12 nanoprecipitates after aging treatment. The samples after longer-time aging treatment show stronger strain hardening as compared to those after shorter-time aging treatment. The hetero-deformation-induced (HDI) hardening plays a more vital role in the longer-time aged samples than the shorter-time aged samples, especially at the elasto-plastic transition stage. The dominant precipitation hardening mechanism is observed to transit from dislocation-cutting to Orowan dislocation-looping with increasing precipitation size, as predicted by a theoretical model and validated by experimental results. Multiple deformation defects, such as deformation twins, stacking faults and Lomer-Cottrell locks, are the dominant deformation mechanisms for all samples, while interactions between these defects and L12 nanoprecipitates were observed to be more intensive in the longer-time aged samples than in the shorter-time aged samples, resulting in stronger precipitation and HDI hardening.

Microstructure evolution and aging behavior of surface-nanocrystallized WE43 Mg alloy by ultrasonic shot peening at a cryogenic temperature

In this study, the microstructure evolution and aging behavior of surface-nanocrystallized WE43 Mg alloy induced by ultrasonic shot peening at a cryogenic temperature were examined. The results reveal that the original coarse grains with an average grain size of 46.7 μm were refined to nanocrystalline grains with 31.5 nm in the nanocrystalline region, demonstrating a marked grain refinement effect. After aging treatment, the nanocrystalline region experienced two aging stages. During Stage Ⅰ, there was a rapid increase in hardness, and in Stage Ⅱ, it reached a maximum of 154.2 HV, representing a 105.6% improvement over the solution-treated alloy. Further microstructural characterization indicates that solute segregation initially occurred along the grain boundaries, leading to a rapid increase in hardness during Stage Ⅰ. Subsequently, two types of precipitates were observed both at the grain boundaries and within the grains during Stage Ⅱ, with the combined effects of solute segregation and precipitation contributing to a further increase in hardness.

Microstructure and properties of Cu–Ni–Si–Cr alloy fabricated by vacuum-assisted die casting via direct aging

In this study, the Cu−3.18Ni−0.75Si−0.28Cr (wt.%) alloy was fabricated using vacuum-assisted die casting (VADC), and the microstructure and properties of the alloy before and after direct aging treatment were investigated. The synergistic effects of pressure and high cooling rate during the VADC process yield excellent composition uniformity within the alloy, characterized by fine-grained microstructures and the formation of a high-energy metastable supersaturated solid solution. The subsequent direct artificial aging (723 K/6 h) leads to the precipitation of nano-sized δ−Ni2Si phases, thereby enhancing both the mechanical properties and electrical conductivity of the VADC alloy. The alloy exhibited an impressive synergy of the ultimate tensile strength (659 ± 14 MPa), hardness (250.7 ± 3.8 HV), and elongation (21.5 ± 3.6 %), with an excellent conductivity of 32.3 ± 0.4 % IACS. With the considerable potential for industrial applications, the novel fabrication method enables high-efficiency preparation and near-net shape forming of high-performance Cu–Ni–Si–Cr alloy.

Influence of Single Aging Treatment on the Mechanical Properties of Additively Manufactured Ultra-Thin 18Ni-300 Maraging Steel

Influence of Single Aging Treatment on the Mechanical Properties of Additively Manufactured Ultra-Thin 18Ni-300 Maraging Steel

Enhancing plasticity in BCC Mg-Li-Al alloys through controlled precipitation at grain boundaries

This study investigates the improvement of plasticity in body-centered cubic magnesium (Mg)-lithium (Li)-aluminum (Al) alloys, crucial for lightweight structural applications. The ternary Mg-Li-Al alloys exhibits high strength but low ductility. Precipitates at grain boundaries in these alloys, linked to reduced plasticity, are examined for their crystal structure and composition. Advanced microscopic techniques reveal the transformation of precipitates and the development of specific structures at grain boundaries. Thermodynamics of element diffusion at grain boundaries are explored through first-principles calculations, and a phase-field simulation models precipitate evolution. Molecular dynamics simulations elucidate nanoscale mechanisms governing the transition from brittle to ductile fracture modes during artificial aging. The D03−Mg3Al at grain boundaries is a brittle phase, and through a 170 °C aging treatment, it induces the precipitation of lamellar α-Mg phase with D03−Mg3Al as nucleation sites. The occupancy energy of Al atoms at Li sites in α-Mg is found to be lower than that in D03−Mg3Al, leading to the dissolution of D03−Mg3Al. The α-Mg, characterized by a stronger metallic nature, exhibits a better-matched modulus with the matrix and enhanced dislocation mobility. The precipitation of α-Mg plays a pivotal role in significantly improving the ductility of the alloy. This work contributes to the understanding of the complex interplay between alloy composition, grain boundary precipitates, and plasticity, as well as brings insights to guide interfacial control in the development of advanced Mg-Li-Al alloys for structural applications.

Sustainable synergistic adsorption of tetracycline in water by biochar and microplastics: Exploration of the mechanism of DFT

Microplastics (MPs) were found to be a novel carrier for tetracycline (TC) in aquatic environments. Therefore, the synergistic adsorption treatment of TC in water based on biochar (BC) and MPs was explored in this study. Polyethylene, polypropylene, and polyvinyl chloride were selected for aging treatment and added to biochar obtained from vitamin C-modified crayfish shells (CSB-VC), which performed best in preliminary adsorption experiments. The pseudo second order kinetic model and Freundlich isotherm model are more suitable for describing the synergistic adsorption process. Under the synergistic effects of CSB-VC-PE, CSB-VC-PP, and CSB-VC-PVC, the saturation adsorption capacities were determined as 275.99 mg/g, 275.24 mg/g, and 284.48 mg/g, respectively. In actual water experiments, the four adsorption systems still exhibit good synergistic performance with Qe > 245 mg/g. Characterization, experiments, and DFT calculations confirm that van der Waals force, hydrogen bonding and electrostatic interaction were the main adsorption mechanisms in the synergistic interactions between CSB-VC and MPs. The study of the synergistic adsorption mechanism between biochar and MPs provides a foundation for further comprehensive research on the sustainable development of complex solutions to various environmental pollution problems.

Manipulation of the α-phase precipitation behavior through dual-aging treatment and its correlation with mechanical properties in a metastable β titanium alloy

The precipitation behavior of α-phase and its crucial impact on the mechanical properties have been investigated in a metastable β-type Ti-4Al-6V-5Mo-3Cr-1Zr (wt%, Ti-46531) alloy. Through dedicated design of dual-step aging conditions, the nucleation mechanism, number density and morphology of the secondary α-phase precipitates can be modulated. After the first-step aging treatment at 300 °C for 5−100 h, isothermal ω-phase (ωiso) particles precipitate and are uniformly dispersed in the β-phase matrix, with their number density gradually increasing with aging time. The subsequent second-step aging treatment at 600 °C for 2 h leads to the rapid dissolution of ωiso and the precipitation of α-phase through the classical nucleation process with a steady number density. Lowering the second-step aging temperature to 520 °C promotes the heterogeneous nucleation of the α-phase with the assistance of uniformly dispersed ωiso particles. This leads to a significant increase in the number density of α-phase precipitates. Consequently, the maximum yield strength increases from 1296 MPa for samples aged at 600 °C to 1623 MPa for samples aged at 520 °C. The precipitation of α-phase serves a dual role in enhancing the yield strength, both by providing precipitation strengthening and by increasing dislocation density. The contribution to yield strength enhancement from the former effect is considerably more substantial than the latter. This work underscores the crucial role of α-phase number density in determining the strength of metastable β titanium alloys, offering new insights into the tailoring of microstructures and mechanical properties through dual-aging treatments.

Enhanced mechanical properties and anti-wear performance of Cu45Mn8Ni40Sn7 medium entropy bronze alloy by multi-stage heat treatment

High/ medium entropy brass and bronze alloys exhibit considerable potential for application as structural materials. This study focuses on a Cu45Mn8Ni40Sn7 medium entropy bronze alloy that demonstrates excellent hardness, compressive strength, ductility, and wear resistance through a multi-stage heat treatment technique. The effects of heat treatment on the phase composition, microstructural evolution, mechanical properties, and tribological performance of the alloy were systematically investigated. The alloy, treated by homogenization (820 ℃/4 h)-solution (900 ℃/1 h)-aging (450 ℃/5 h), exhibits a hardness of 362 HV, yield strength of 626 MPa, ultimate strength of 1229 MPa, compressive strain of 47.2 %, fracture toughness of 20.7 MPa·m1/2, and maintains a low wear rate of 1.72×10−5 mm3·N−1·m−1. The processes of homogenization and solution treatment reduce dendrite segregation of elements and eliminate the detrimental lamellar structure at the grain boundaries. During the aging treatment of the alloy, sub-micron scale needle-like precipitates are formed, which play a significant role in enhancing its mechanical properties.

Direct aging treatment of TiN modified Al–Mn–Sc alloy processed by laser powder bed fusion: On the microstructure evolution and mechanical property enhancement

In this study, the TiN nanoparticles modified Al–Mn-Sc composite and Al–Mn-Sc alloy have been fabricated by the laser powder bed fusion (LPBF). The microstructure, mechanical properties and strengthening mechanisms of these materials were discussed in details for both the as-built and artificial aged conditions. The results showed that the aged Al–Mn-Sc/TiN composite exhibits homogeneous nucleation with equiaxed grains ranging from 0.81 μm to 1.30 μm. After direct aging treatment of 300 °C, there are a volume fraction of secondary L12-Al3(Ti, Sc, Zr) nanoparticles precipitated in the composite sample, contributing to an ultra-high fracture strength of 701 ± 16 MPa. The increment in strength brought by TiN mainly comes from fine grains and high volume fraction of L12-Al3(Ti, Sc, Zr) nanoprecipitates. The fracture behaviors suggest that the uniform distribution of reinforced particles and less amount of micro pores can improve the strength and ductility of LPBF particle reinforced aluminum matrix composites.

The difference between tire wear particles and polyethylene microplastics in stormwater filtration systems: Perspectives from aging process, conventional pollutants removal and microbial communities

Tire wear particles (TWPs) in stormwater runoff have been widely detected and were generally classified into microplastics (MPs). TWPs and conventional MPs can be intercepted and accumulated in stormwater filtration systems, but their impacts on filtration, adsorption and microbial degradation processes of conventional pollutants (organic matters, nitrate and ammonium) have not been clarified. TWPs are different from MPs in surface feature, chemical components, adsorption ability and leaching of additives, which might lead to their different impacts on conventional pollutants removal. In this study, five different levels of aged polyethylene MPs (PEMPs) and aged TWPs contamination in stormwater filtration systems were simulated using thirty-three filtration columns. Results showed that ultraviolet aging treatment was less influential for the aging of TWPs than that of PEMPs, the specific surface area of aged PEMPs (1.603 m2/g) was over two times of unaged TWPs (0.728 m2/g) in the same size. Aged PEMPs and aged TWPs had different impacts on conventional pollutants removal performance and microbial communities, and the difference might be enlarged with exposure duration. The intensified aged PEMPs contamination generally promoted conventional pollutants removal, whereas aged TWPs showed an opposite trend. Mild contamination (0.01% and 0.1%, wt%) of aged PEMP/TWPs was beneficial to the richness and diversity of microbial communities, whereas higher contamination of aged PEMPs/TWPs was harmful. Aged PEMPs and TWPs had different impact on microbial community structure. Overall, the study found that TWPs were more detrimental than PEMPs in filtration systems. The research underscores the need for more comprehensive investigation into the occurrence, effects and management strategies of TWPs, as well as the importance of distinguishing between TWPs and MPs in future studies.

Role of the aging procedure on the ω + β microstructure in the metastable β Ti-30Nb-3Fe alloy

This report investigated the effect of low-temperature aging on the ω + β microstructure in the Ti-30Nb-3Fe alloy (wt%). Samples were subjected to several aging procedures. The ω + β microstructure remained quite stable under conventional transmission electron microscopy across most temperature/time regimes. Only the double aging treatment led to the growth of ω particles and an increased in Vickers hardness, indicating that the pre-aging treatment was necessary to promote rapid ω growth in the subsequent treatment. Furthermore, the early stages of solute partitioning that accompanies ω growth did not drastically increase hardness, suggesting that no embrittlement occurred.

Genomic profiles and clinical presentation of chordoma

Chordoma is a rare bone cancer with variable clinical outcomes. Here, we recruited 184 sporadic chordoma patients from the US and Canada and collected their clinical and treatment data. The average age at diagnosis was 45.5 years (Range 5–78) and the chordoma site distribution was 49.2% clivus, 26.2% spinal, and 24.0% sacral. Most patients (97.5%) received surgery as the primary treatment, among whom 85.3% also received additional treatment. Except for the most prevalent cancers like prostate, lung, breast, and skin cancer, there was no discernible enrichment for any specific cancer type among patients or their family members. Among a subset of patients (N = 70) with tumor materials, we conducted omics analyses and obtained targeted panel sequencing and SNP array genotyping data for 51 and 49 patients, respectively. The most recurrent somatic driver mutations included PIK3CA (12%), followed by chromatin remodeling genes PBRM1 and SETD2. Amplification of the 6q27 region, containing the chordoma susceptibility gene TBXT, was detected in eight patients (16.3%). Clival patients appeared to be less likely to carry driver gene mutations, chromosome arm level deletion events (e.g., 5p, 5p, and 9p), or 6q27 amplification compared to sacral patients. After adjusting for age, sex, tumor site, and additional treatment, patients with somatic deletions of 14q (OR = 13.73, 95% CI 1.96–96.02, P = 0.008) and 18p (OR = 13.68, 95% CI 1.77–105.89, P = 0.012) were more likely to have persistent chordoma. The study highlights genomic heterogeneity in chordoma, potentially linked to location and clinical progression.

Effects of magnetic field heat treatment on magnetic properties and microstructure of Sm2Co17-type sintered magnets

Sm2Co17-type sintered magnets have attracted widespread attention for their excellent magnetic properties and thermal stability. The magnetic properties largely depend on the cellular structure and Cu, Fe distributions within these magnets. This paper systematically studies the effect of magnetic field heat treatment (MFHT) on the magnetic properties and microstructure of Sm2Co17-type sintered magnets. MFHT improves the room-temperature magnetic properties and remanence temperature stability of magnets but slightly deteriorates the temperature coefficient of intrinsic coercivity. A microstructure analysis shows that MFHT improves the cell boundary phase content and optimizes the cellular structure and Cu, Fe distributions of magnets. A high-density short lamellar phase, possibly induced by MFHT, provides easy diffusion paths for Cu and Fe, thereby improving the magnetic properties of magnets. Compared with conventional aging treatment, this paper proposes a promising method to improve the magnetic properties of Sm2Co17-type sintered magnets under the same heat treatment time and temperature.

Effects of post heat treatment on key T-phase evolution and the matching mechanism of enhanced strength-toughness, wear resistance and corrosion resistance in Al-Mg-Zn-(Cu-Er-Zr) alloy by laser powder bed fusion

Al-Mg-Zn-(Cu-Er-Zr) system alloy is a novel alloy designed by materials genetic method for laser additive manufacturing of lightweight brake discs and the T-phase (T-AlMgZnCuZrEr) in this alloy is the most important microstructure for enhancing performance matching of the alloy. Scientifically regulating the T-phase evolution through innovative preparation processes to improve the matching of strength-toughness, wear resistance, and corrosion resistance in this novel alloy is the fundamental work for preparing high-performance lightweight high-speed train brake disc parts using laser additive manufacturing. In this work, laser powder bed fusion and post heat treatments were employed to prepare Al-Mg-Zn-(Cu-Er-Zr) alloy samples with the superior matching of strength-toughness, wear resistance and corrosion resistance, and the key T-phase evolution and performance enhancement mechanisms of the samples were studied. The results indicate that post heat treatments significantly influenced the quantity, size, and structure of the T-phase in the cladded sample, which significantly enhanced the strength-toughness, wear resistance and corrosion resistance matching of the alloy. It is found that under the optimized aging treatment at 200 °C/6 h, due to the evolution of T-phase area fraction and cell-like structure inside the T-phase, the strength-toughness, wear resistance and corrosion resistance were improved by 30 %, 28 %, 1.4 %, respectively. The precipitation and concave dissolution mechanisms of the T-phase during post heat treatment have been finely revealed, and a three-performance matching relationship model has been successfully constructed based on the strength-toughness matching equation. A new laser powder bed fusion followed by the aging process to manufacture an Al-Mg-Zn-(Cu-Er-Zr) alloy sample with the superior matching of strength-toughness, corrosion resistance, and wear resistance has been obtained, which provides a valuable reference for laser additive manufacturing high-performance lightweight aluminum alloy brake disc parts.