Aging Process Research Articles

Effect of organic matter on the environmental behavior of sulfur and heavy metals in mariculture sediments during the aging process

Organic matter (OM) significantly impacts the environmental behavior of sulfur and heavy metals. In this study, the effects of OM on the migration and transformation of sulfur and heavy metals in mariculture sediments were investigated. The results indicated that baiting had a strong impact on the accumulation of acid volatile sulfur (AVS) (P < 0.05) and increased the environmental risk of sulfide in sediments. The addition of bait promoted the generation of chromium (II)-reducible sulfur (CRS); however, the resistance of AVS to CRS conversion increased with increasing bait addition. The addition of bait considerably influenced Cd accumulation. The acid-soluble fractions of Cr and Cu and the oxidizable fraction of Cd were primarily affected by the bait addition (coefficient of variation>15 %). An increase in the reducible fraction promoted the conversion of AVS to CRS, which reduced the degree of sediment aging. Higher OM levels reduced the diversity and abundance of the bacterial communities. The sulfate respiration functional microbiota was particularly affected by OM.

Irisin, A Fascinating and Multifunctional Protein: Implication for Health

BACKGROUND: Fibronectin type III domain-containing protein 5 (FNDC5), or also known as irisin, has been identified for two decades but almost completely disregarded for 10 years. It is present in skeletal muscle, heart, and brain, and in reaction to exercise can transform white adipose tissue into brown. Since then, irisin has gained a lot of attention for its potencies in treating metabolic disorders. In this review article, the potential future of irisin especially on metabolism and aging process will be discussed.CONTENT: Sedentary lifestyle is acknowledged as risk factor for type 2 diabetes mellitus, obesity, immune system issues, asthma, and neurological or heart illness. Irisin is secreted by muscle cells when exercising, produced after the proteolytic cleavage of FNDC5 protein. Irisin has positive impacts on maintaining physiological balance including reducing inflammation, keeping the bone homeostasis, as well as influencing metabolic processes and the neurological system function. Due to these many and advantageous characteristics, irisin could be a possible choice for preventing and managing disorders associated with modern society, and finding the agents to increase irisin can be beneficial.SUMMARY: Irisin offers a fresh potential basis for kinesitherapy and shows promise as a therapeutic target due to its various biological activities. Irisin pathway can be activated through dietary changes, the use of natural substances and drugs and can interact with this signalling pathway which involved peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) and uncoupling protein mRNA 1 (UCP1) to resolve obesity and its metabolic comorbidities.KEYWORDS: irisin, FNDC5, exercise, inflammation, obesity, nervous system

Loneliness and Emotional Levels of the Elderly: Correlation Study in Karang Werda Peer Group

Introduction: The elderly are a vulnerable group who experience the aging process, physical and psychological health problems. Prolonged loneliness results in decreased immunity, sleep disturbances, emotional mental disorders, depression, and even suicide. Purpose: This study was to analyze the correlation between loneliness and the emotional level of the elderly in Karang Werda, Balung District, Jember Regency. Methods: This study used quantitative research methods with a correlational descriptive approach and a cross sectional design. The sample is 108 elderly with the Stratified Random Sampling technique. Loneliness data collection using the UCLA Loneliness Scale Version 3 and emotional levels using the Emotion Regulation Questionnaire (ERQ). Results: It was found that (79%) of the elderly experienced mild loneliness and (79%) had a good emotional level. The correlation between loneliness and emotional level result obtained (p= 0,003, r= -0.202). Conclusion: There is a correlation between loneliness and the emotional level of the elderly in Karang Werda, Balung District, Jember Regency. It is hoped that the elderly can relate well to the surrounding environment and actively participate in group activities. Nurses must carry out routine psychological care for the elderly and provide appropriate interventions.

Towards Understanding Formation Mechanism of Cellular Structures in Laser Powder Bed Fused AlSi10Mg.

A new approach is proposed that identifies three different zones of the Si-rich network structure (the cellular structure) in laser powder bed fused (LPBF) AlSi10Mg alloy, based on the variation in morphology, grain growth transition, and melt pool solidification conditions. The three identified zones are denoted in the present work as the liquid solidification zone (LSZ), the mushy solidification zone (MSZ), and the heat affected zone (HAZ). The LSZ is the result of liquid-solid transformation, showing small planar growth at the boundary and large cellular growth in the center, while the MSZ is related to a semisolid reaction, and the HAZ arises from a short-time aging process. The boundary between the LSZ and MSZ is identified by the change of grain growth direction and the Si-rich network advancing direction. The boundary between MSZ and HAZ is identified by the start of the breakdown of the Si-rich network. In addition, it is found that the fracture is generated in and propagates along the HAZ during tensile tests.

THEORETICAL AND PRACTICAL RESEARCH ON CHINA'S RESPONSE TO POPULATION AGING IN THE NEW ERA

Population aging is an important trend of social development. At present, China is in the largest aging process in history, catching up with or even surpassing the aging speed of Western countries in the rapid evolution, with many pressures and challenges under the complex internal and external environment. China has put forward a series of new theories, new ideas and new strategies on the work of aging, forming a theoretical system with rich connotation, complete system and strict logic, which guides the practice of the Chinese government to deal with population aging. This paper deeply analyzes the relevant theoretical basis, analyzes the current situation, characteristics and causes of China's aging, and summarizes the practice of China's innovative response to aging since 2010, in order to provide valuable experience for the rest of the world to deal with aging.

Bioanthropological and Biomechanical Perspectives on Skeletal Senescence Variation: A Literature Review

Background: Senescence is the deterioration of the body’s biological and physiological function throughout later life. Senescent populations are more prone to diseases, though other than osteoporosis, skeletal senescence is a less discussed topic in Indonesia. Furthermore, a global and national increase in the aging population showed that they will be a major group in society, thus raising the urgency to review this matter. This study aims to comprehend the physiological and biomechanical mechanisms of skeletal senescence, as well as senescent variations in a certain sex or population affinity. Literature Review: Age-related skeletal cellular death and imbalance contribute to bone damage in elders. Senescence also affects skeletal biomechanics, expressed in increased bone porosity and brittleness. Stresses in aged bone risk straining above its elastic limit and causing fractures due to its inability to tolerate stresses. The loss of sex hormones is related to skeletal senescence, especially in females, though the effects of testosterone on skeletal senescence are underresearched. Dietary change, estrogen replacement therapy, and calcitonin consumption are effective measures in reducing the effects of osteoporosis. Variations were found in the bone aging process in different populations, especially regarding bone mineral density loss in white, African-American, Asian, and Hispanic populations. Summary: Specific population-based healthcare services in geriatrics and gerontology are highly suggested to ensure inclusive healthcare for every aged individual. Due to the minimum data about bone aging in Indonesia (other than osteoporosis), the authors encourage data procurement on local populations to create more suitable medical guidelines for elders in Indonesia.

On the Relationship between MMA Levels in Blood Products and Donor Sex, Age, and Donation Frequency.

As the aging process accelerates, the age structure of blood donors turns to older and even aged groups. Methylmalonic acid (MMA), a byproduct of propionate metabolism, may be upregulated in the serum of older adults. As a mediator of chronic disease and tumor progression, the MMA content in blood products has become the focus of research. Absolute concentrations of MMA in blood products were determined based on the liquid chromatography-tandem mass spectrometry, so as to analyze how they were affected by donors' age, sex, and frequency of blood donation. The MMA content in leukocyte-depleted suspended red blood cell (lds-RBC) was significantly higher than that in fresh plasma (p<0.0001). The MMA content among five age groups showed no difference in either fresh plasma or lds-RBCs. The MMA content in fresh plasma was similar in the parameters of the sex, whereas that in lds-RBCs was higher in males than that in females (p=0.035). There were no significant differences in MMA content when it comes to different frequencies of blood donors in either fresh plasma or lds-RBCs. Additionally, there was no significant difference or clear trend in the rate of elevated plasma MMA levels among different sexes, age groups, and blood donation frequency groups. MMA in the blood products from donors in China does not compromise the safety of blood transfusions for cancer patients. Nevertheless, there is a need to focus on MMA levels in Chinese and to develop race-specific and age-specific normal reference ranges.

Evaluation of the Effect of Different Bonding Systems and Restorative Materials on Shear Bond Strength in the Repair of High-Viscosity Glass Ionomer Cement

Aim: High viscosity glass ionomer cements have been produced to increase the mechanical properties of glass ionomer cements. The aim of this study is to determine the appropriate adhesive system and restorative material that can be used in fracture repair of high viscosity glass ionomer cements. Material and Methods: A total of 140 standard size acrylic blocks were used in the study. 14 groups were formed from randomly selected acrylic blocks, with 10 samples in each group. High viscosity glass iomomer cement was placed in the first 13 groups, and resin-modified glass ionomer cement was placed in the last group. After the thermal cycle aging process was applied to all samples, repair restorations were performed with 4 different adhesive systems, 2 different composite resins and 2 different restorative types of glass ionomer cement. After the repair restorations, thermal cycle aging was applied again and the shear bond strengths were evaluated. One-way analysis of variance and Duncan multiple comparison test were used for statistical analysis. Results: The highest shear bond strength values were obtained by the total etch adhesive system (p&lt;0.001). The lowest shear bond strength values were obtained when high-viscosity glass-iomomer cement without adhesive system was restored with high-viscosity glass iomomer cement (p&lt;0.001). Conclusion: For higher shear bond strength values in the repair of high-viscosity glass ionomer cements should use to total etch adhesive systems and composite resin.

Curcumin attenuates brain aging by reducing apoptosis and oxidative stress.

Brain aging is a physiological event, and oxidative stress and apoptosis are involved in the natural aging process of the brain. Curcumin is a natural antioxidant with potent anti-aging and neuroprotective properties. Therefore, we investigated the protective effects of curcumin on brain apoptosis and oxidative stress, brain-derived neurotrophic factor (BDNF), and vascular endothelial growth factor (VEGF) in aged rats. Old female Wistar rats were randomly divided into three groups (n = 7); as follows: (1) control; (2); saline and (3) curcumin (received 30mg/kg of curcumin, 5 days/week for 8 weeks, intraperitoneally). Our results indicated that treatment with curcumin in aged rats attenuates brain lipid peroxidation, which was accompanied by a significant increase in the BDNF, VEGF, superoxide dismutase (SOD) activity, and anti-apoptotic protein BCl-2. No significant change in brain anti-apoptotic Bax protein levels was observed after curcumin treatment. The study indicates that curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis, and up-regulating SOD activity, which in turn enhances VEGF and BDNF. Therefore, curcumin has potential therapeutic value in the treatment of neurological apoptosis, neurogenesis, and angiogenesis changes caused by brain aging.

Cognitive Decline, Depression, and Sarcopenia: A risk for home care

Abstract Background: The aging process involves a decline in mental and physical abilities. Objective: The aim of this study is to assess the relationship between cognitive decline, depression, and sarcopenia in the community-dwelling elderly population. Methods: This is a quantitative, cross-sectional study. The evaluations were started with a form that contained information of body characteristics (age, sex, height, weight, Body Mass Index, Total Muscle Mass, Total Muscle Mass Index, Abdominal Circumference), sarcopenia characteristics (Calf Circumference, Timed Up and Go Test, Walking Speed Test, Sit and Stand Test, Handgrip Strength Test, and Quadriceps Femoral Strength Test), for the assessment of cognitive decline (Clock Drawing Test), and for depression (Geriatric Depression Scale). Results: A total of 266 community-dwelling elderly people participated in this study, of whom 1/3 had pre-sarcopenia. It was possible to verify that in the Clock Drawing Test (p=0.037) and in the Geriatric Depression Scale (p=0.001), as well as in their question repartition, the group of elderly with pre-sarcopenia presented the worst results. Conclusion: At the end of the study, it was possible to conclude that cognitive decline, depression, and sarcopenia, in fact, are associated. Keywords: Aged, Cognitive Decline, Depression, Sarcopenia.

PELATIHAN KADER DALAM SKRINING PENYAKIT DEGENERATIF PADA LANSIA

Elderly experienced degenerative diseases due to the aging process. Decreased organ function causes several symptoms that decrease life quality. Elderly in Banjar Tatasan Kaja, Denpasar, Bali also have several symptoms and reduce their activities. Even though there is regular exercise every week, they never undergo health screening. We conduct training to screen for degenerative diseases for elderly cadres, health screening and health promotion for the elderly. Five cadres (100%) were trained to do health screening. Screening tools are handed over to the head of the cadre. Furthermore, elderly cadres assist doctors and midwife to help to do health screening activities. Forty-four elders participate in health promotion and screening. Health promotion was about degenerative diseases and tips to improve physical activities. The result of this program is skill improvement of elderly cadres and knowledge improvement of elderly about degenerative diseases. The pre-test average is 23.95% and the post-test average is 85.12%. The knowledge score increased by about 61.17%. Elderly who have some symptoms can consult with the community service team doctor. The program went well and the cadre will continuously do the health screening.

Dynamics of Wnt/β-catenin reporter activity throughout whole life in a naturally short-lived vertebrate.

Wnt/β-catenin signaling plays a major role in regulation of embryogenesis, organogenesis, and adult tissue homeostasis and regeneration. However, the roles played by Wnt/β-catenin and the spatiotemporal regulation of its activity throughout life, including during aging, are not fully understood. To address these issues, we introduced a Wnt/β-catenin signaling sensitive reporter into African turquoise killifish (Nothobranchius furzeri), a naturally ultra-short-lived fish that allows for the analysis of its whole life within a short period of time. Using this reporter killifish, we unraveled the previously unidentified dynamics of Wnt/β-catenin signaling during development and aging. Using the reporter strain, we detected Wnt/β-catenin activity in actively developing tissues as reported in previous reports, but also observed activation and attenuation of Wnt/β-catenin activity during embryonic reaggregation and diapause, respectively. During the aging process, the reporter was activated in the choroidal layer and liver, but its expression decreased in the kidneys. In addition, the reporter also revealed that aging disrupts the spatial regulation and intensity control of Wnt/β-catenin activity seen during fin regeneration, which interferes with precise regeneration. Thus, the employed reporter killifish is a highly useful model for investigating the dynamics of Wnt/β-catenin signaling during both the developmental and aging process.

Magnetoencephalography-derived oscillatory microstate patterns across lifespan: the Cambridge centre for ageing and neuroscience cohort.

The aging brain represents the primary risk factor for many neurodegenerative disorders. Whole-brain oscillations may contribute novel early biomarkers of aging. Here, we investigated the dynamic oscillatory neural activities across lifespan (from 18 to 88 years) using resting Magnetoencephalography (MEG) in a large cohort of 624 individuals. Our aim was to examine the patterns of oscillation microstates during the aging process. By using a machine-learning algorithm, we identify four typical clusters of microstate patterns across different age groups and different frequency bands: left-to-right topographic MS1, right-to-left topographic MS2, anterior-posterior MS3 and fronto-central MS4. We observed a decreased alpha duration and an increased alpha occurrence for sensory-related microstate patterns (MS1 & MS2). Accordingly, theta and beta changes from MS1 & MS2 may be related to motor decline that increased with age. Furthermore, voluntary 'top-down' saliency/attention networks may be reflected by the increased MS3 & MS4 alpha occurrence and complementary beta activities. The findings of this study advance our knowledge of how the aging brain shows dysfunctions in neural state transitions. By leveraging the identified microstate patterns, this study provides new insights into predicting healthy aging and the potential neuropsychiatric cognitive decline.

Evaluating the effect of paper waste lignin in hot mix asphalt

Asphalt is a viscoelastic material which performs to resist rutting, fatigue cracking, and moisture susceptibility under different loading and temperature conditions. The use of innovative and renewable pavement construction materials is inevitable due to high axle loads, rapidly increasing traffic volumes, and varying climatic conditions. This study aims to assess the effect as well as the optimum dosage of paper waste lignin for use in hot mix asphalt (HMA). Lignin from the paper industry with dosage ratios of 5, 10, 15, and 20%, was utilized to study the effect of the addition of lignin to the asphalt binder. Virgin and lignin-modified binder samples, before and after the aging process, were subjected to physical testing through penetration, softening point, ductility, viscosity and specific gravity and rheological characteristics through dynamic shear rheometer (DSR), bending beam rheometer (BBR), and rational viscometer (RV). The fractional composition was assessed through saturates, aromatics, resins and asphaltenes (SARA) fractional composition technique. Statistical analysis was also performed to find correlation of different physical and rheological parameters. Furthermore, based on optimum dosage, the performance of asphalt mixtures was studied against rutting, fatigue cracking, and moisture susceptibility. The results indicated that the addition of lignin has improved the physical properties significantly. The amount of asphaltene decreased and aromatics increased in SARA fractional analysis. Moreover, the Colloidal Instability Index (CII) has also indicated a stable structure of the binder. The rheological characteristics are improved after modification. The asphalt mixture tests revealed that addition of lignin with optimum dosage (10%) has improved the performance against rutting, fatigue cracking and moisture susceptibility. Statistical analysis indicated good co-relation among different physical and rheological parameters. This study concludes that 10% dosage is the optimum dosage that can successfully replace the virgin asphalt binder for performance of hot mix asphalt.

The Role And Impact Of Outdoor Walks, Combined With A Special Recreational Exercise Program, In Improving Lower Limb Strength And Motor Balance In 55-65 Year Olds

Sports participation is declining in most countries starting at age 12, with the tendency becoming considerably more noticeable as people get older. The most industrialized nations experience a demographic shift that leads to an older population due to declining birth rates and improvements in healthcare. The objective of this literature review is to analyse the existing data to discover the rates, current trends of sports participation, health problems and ways of preventing and improving it through exercise therapies of a recreational nature in the 55-65 age group in Albania and the world. 54 articles from Google Scholar, 16 articles from Crossref, 22 articles from PubMed, 14 papers from Research Gate, and 11 books (a total of 117 references) that were chosen for preliminary screening were evaluated using a methodical methodology. Upon through examination, 29 articles, or 25% of the total, satisfied the requirements to be regarded as legitimate for the subject at hand. The current condition of lower limb strength and balance in both the experimental and control groups will be determined through preliminary laboratory testing. Two instruments from the Sports University of Tirana biomechanics lab; the Leonardo Platform and the Isokinetic Dynamometer will be employed for the aforementioned measurements. We estimate that the study sample will consist of 60–90 working-age men and women who fall into the 55–65 age range. The systematic literature review and meta-analysis aims to define quantitative relationships of lower limb strength with balance improvement. Due to the accelerated aging process, the middle-aged population experiences a decline in strength, endurance, flexibility, and muscle mass (sarcopenia), which impairs coordination, stability, and balance. Keywords: outdoor walks, special recreational exercises, lower limb strength, age group 55-65, balance, quality of life.

Quantitative Analysis of Active Lithium Loss and Degradation Mechanism in Temperature Accelerated Aging Process of Lithium‐Ion Batteries

AbstractQuantifying the aging mechanisms and their evolution patterns during battery aging is crucial for enabling renewable energy. Here, key factors are monitored and quantified affecting the aging processes of LiFePO4//graphite battery by a combination of mass spectrometry titration (MST), nuclear magnetic resonance (NMR), cryogenic transmission electron microscopy (cryo‐TEM), and neutron imaging techniques. Electrochemical analysis reveals the loss of active lithium inventory drives battery aging as temperature increases. It is shown that temperature‐induced accelerated decaying rate is 2.01 and 3.45 times at 45 and 65 °C compared with that of rate at 25 °C. Quantitative analysis indicates that irreversible formation of LixC6 (x ≤ 1), LiF, ROCO2Li, LiH, Li2C2, and RLi (R = CH3, C2H3, C2H5, C3H5) are the primary components of inactive lithium. The solid eletrolyte interpahse (SEI), excluding LixC6, constitutes over 70% of the total inactive lithium. With increasing cycles, SEI shows a decreasing proportion of LiF and an increasing proportion of ROCO2Li. The coupled effects of substantial SEI growth, increased irreversible formation of LixC6, and worsened conductivity result in the rapid aging of batteries tested at high temperatures. In this work, a research toolbox for the quantitative study of aging mechanisms in practical batterysystems has been provided.

Evolution of asphalt performance under the coupled aging of ultraviolet, high temperature and water

During the service of asphalt pavement, it is affected by natural environmental factors for a long time, and the pavement performance declined. In order to simulate the cumulative effects of multiple aging components, the indoor "ultraviolet radiation, high temperature and water" multi-factor cyclic coupling aging test was designed. The properties of asphalt during cyclic coupled aging were measured by conventional physical properties tests, photoelectric colorimetric tests, and Fourier Transform Infrared Spectroscopy test. Then the surface morphology of asphalt was observed by camera and optical microscope. After asphalt aged, a large number of oxidation functional groups were formed, causing asphalt to become hard and brittle, adhesion to diminish, and surface roughness to increase. Ultraviolet light and high temperatures led to the exudation and dissolution of the liquid constituents within the asphalt, which were subsequently washed away by water. The thermal stress induced the shrinkage and wrinkle of the asphalt film, resulting in the formation of cracks. Under high temperatures, a limited number of cracks could potentially self-repair during the early stages of aging. Nevertheless, as the aging process progressed, the self-healing capacity of the asphalt diminished, leading to the widening and deepening of cracks. Concurrently, water infiltrated along the cracks into the inner layers of the asphalt, exacerbating the degradation of its properties.

Targeting Aging and Longevity with Exogenous Nucleotides (TALENTs): Rationale, Design, and Baseline Characteristics from a Randomized Controlled Trial in Older Adults.

Nucleotides (NTs), important biomolecules involved in numerous cellular processes, have been proposed as potential candidates for anti-aging interventions. However, whether nucleotides can act as an anti-aging supplement in older adults remains unclear. TALENTs is a randomized, double-blinded, placebo-controlled trial that evaluates the efficacy and safety of NTs as an anti-aging supplement in older adults by exploring the effects of NTs on multiple dimensions of aging in a rigorous scientific setting. Eligible community-dwelling adults aged 60-70 years were randomly assigned equally to two groups: nucleotides intervention group and placebo control group. Comprehensive geriatric health assessments were performed at baseline, 2-months, and 4-months of the intervention. Biological specimens were collected and stored for age-related biomarker testing and multi-omics sequencing. The primary outcome was the change from baseline to 4 months on leukocyte telomere length and DNA methylation age. The secondary aims were the changes in possible mechanisms underlying aging processes (immunity, inflammatory profile, oxidative stress, gene stability, endocrine, metabolism, and cardiovascular function). Other outcomes were changes in physical function, body composition and geriatric health assessment (including sleep quality, cognitive function, fatigue, frailty, and psychology). In the RCT, 301 participants were assessed for eligibility and 122 were enrolled. Participants averaged 65.65 years of age, and were predominately female (67.21%). All baseline characteristics were well-balanced between groups, as expected due to randomization. The majority of participants were pre-frailty and had at least one chronic condition. The mean scores for physical activity, psychological, fatigue and quality of life were within the normal range. However, nearly half of the participants still had room for improvement in cognitive level and sleep quality. This TALENTs trial will represent one of the most comprehensive experimental clinical trials in which supplements are administered to elderly participants. The findings of this study will contribute to our understanding of the anti-aging effects of NTs and provide insights into their potential applications in geriatric healthcare.

BMP4 in Human Endometrial Stromal Cells Can Affect Decidualization by Regulating FOXO1 Expression.

Recurrent spontaneous abortion (RSA) is defined as the loss of 2 or more consecutive intrauterine pregnancies with the same sexual partner in the first trimester. Despite its significance, the etiology and underlying mechanisms of RSA remain elusive. Defective decidualization is proposed as one of the potential causes of RSA, with abnormal decidualization leading to disturbances in trophoblast invasion function. To assess the role of bone morphogenetic protein 4 (BMP4) in decidualization and RSA. Decidual samples were collected from both RSA patients and healthy controls to assess BMP4 expression. In vitro cell experiments utilized the hESC cell line to investigate the impact of BMP4 on decidualization and associated aging, as well as its role in the maternal-fetal interface communication. Subsequently, a spontaneous abortion mouse model was established to evaluate embryo resorption rates and BMP4 expression levels. Our study identified a significant downregulation of BMP4 expression in the decidua of RSA patients compared to the normal control group. In vitro, BMP4 knockdown resulted in inadequate decidualization and inhibited associated aging processes. Mechanistically, BMP4 was implicated in the regulation of FOXO1 expression, thereby influencing decidualization and aging. Furthermore, loss of BMP4 hindered trophoblast migration and invasion via FOXO1 modulation. Additionally, BMP4 downregulation was observed in RSA mice. Our findings highlighted the downregulation of BMP4 in both RSA patients and mice. BMP4 in human endometrial stromal cells was shown to modulate decidualization by regulating FOXO1 expression. Loss of BMP4 may contribute to the pathogenesis of RSA, suggesting potential avenues for abortion prevention strategies.

Nano-nutraceuticals to Combat Oxidative Stress: Unlocking Newer Paradigms in Adjuvant Therapy.

Nutraceuticals are products that provide both nutritional and therapeutic benefits. These compounds can slow the aging process and provide physiological effects shielding individuals from acute and chronic diseases. People's interests have shifted from allopathic to Ayurvedic to nutraceuticals in recent years. These are often common dietary supplements that have drawn customers worldwide because of their high nutritional safety and lack of adverse effects when used for a long time. Although conventional dosage forms, including pills, tablets, and semi-solids, are still available, they nevertheless have poorer bioavailability, less stability, and less effectiveness for targeted delivery of bioactives. The use of effective nanocomplex systems as nano-antioxidants using nanotechnology has become a promising field. Among its many uses, nanotechnology is mostly used to create foods and nutraceuticals that are more bioavailable, less toxic, and more sustainable. Additionally, it has been emphasized how precisely nano-pharmaceuticals for oxidative stress produce the desired effects. These improvements show improved antioxidant delivery to the target region, reduced leakage, and increased targeting precision. The outcomes demonstrated that oxidative stress-related illnesses can be effectively treated by lowering ROS levels with the use of nanonutraceuticals. The major ideas and uses of nano-nutraceuticals for health are outlined in this review, with an emphasis on reducing oxidative stress.